eF-site ID 3kck-A PDB Code 3kck Chain A click to enlarge Title A Novel Chemotype of Kinase Inhibitors Classification TRANSFERASE Compound Tyrosine-protein kinase JAK2 Source Homo sapiens (Human) (JAK2_HUMAN) Sequence A:  TQFEERHLKFLQQLGKGGSVEMCRYDPLQDNTGEVVAVKK LQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRR NLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKG MEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQ DKEXXKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVV LYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLK NNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRV DQIRDNM Description (1)  Tyrosine-protein kinase JAK2 (E.C.2.7.10.2) Functional site 1) chain A residue 855 type sequence L description BINDING SITE FOR RESIDUE 3KC A 1 source : AC1 2) chain A residue 863 type sequence V description BINDING SITE FOR RESIDUE 3KC A 1 source : AC1 3) chain A residue 880 type sequence A description BINDING SITE FOR RESIDUE 3KC A 1 source : AC1 4) chain A residue 898 type sequence E description BINDING SITE FOR RESIDUE 3KC A 1 source : AC1 5) chain A residue 911 type sequence V description BINDING SITE FOR RESIDUE 3KC A 1 source : AC1 6) chain A residue 929 type sequence M description BINDING SITE FOR RESIDUE 3KC A 1 source : AC1 7) chain A residue 930 type sequence E description BINDING SITE FOR RESIDUE 3KC A 1 source : AC1 8) chain A residue 931 type sequence Y description BINDING SITE FOR RESIDUE 3KC A 1 source : AC1 9) chain A residue 932 type sequence L description BINDING SITE FOR RESIDUE 3KC A 1 source : AC1 10) chain A residue 983 type sequence L description BINDING SITE FOR RESIDUE 3KC A 1 source : AC1 11) chain A residue 994 type sequence D description BINDING SITE FOR RESIDUE 3KC A 1 source : AC1 12) chain A residue 995 type sequence F description BINDING SITE FOR RESIDUE 3KC A 1 source : AC1 13) chain A residue 1008 type MOD_RES sequence X description Phosphotyrosine; by autocatalysis => ECO:0000305|PubMed:16174768 source Swiss-Prot : SWS_FT_FI5 14) chain A residue 976 type ACT_SITE sequence D description Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10028 source Swiss-Prot : SWS_FT_FI1 15) chain A residue 855 type BINDING sequence L description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2 16) chain A residue 882 type BINDING sequence K description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2 17) chain A residue 868 type MOD_RES sequence Y description Phosphotyrosine; by autocatalysis => ECO:0000250|UniProtKB:Q62120 source Swiss-Prot : SWS_FT_FI3 18) chain A residue 966 type MOD_RES sequence Y description Phosphotyrosine; by autocatalysis => ECO:0000250|UniProtKB:Q62120 source Swiss-Prot : SWS_FT_FI3 19) chain A residue 972 type MOD_RES sequence Y description Phosphotyrosine; by autocatalysis => ECO:0000250|UniProtKB:Q62120 source Swiss-Prot : SWS_FT_FI3 20) chain A residue 1007 type MOD_RES sequence X description Phosphotyrosine; by autocatalysis => ECO:0000269|PubMed:16174768 source Swiss-Prot : SWS_FT_FI4 21) chain A residue 855-883 type prosite sequence LGKGGSVEMCRYDPLQDNTGEVVAVKK description PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGKGNFGSVEmCrydplqdntgevv.....AVKK source prosite : PS00107 22) chain A residue 972-984 type prosite sequence YIHRDLATRNILV description PROTEIN_KINASE_TYR Tyrosine protein kinases specific active-site signature. YIHrDLATRNILV source prosite : PS00109

Display surface Download Links