eF-site ID 3jx3-B PDB Code 3jx3 Chain B click to enlarge Title Structure of rat neuronal nitric oxide synthase D597N/M336V mutant heme domain in complex with N1-{(3'R,4'R)-4'-[(6"-amino-4"-methylpyridin-2"-yl)methyl]pyrrolidin-3'-yl}-N2-(3'-fluorophenethyl)ethane-1,2-diamine Classification OXIDOREDUCTASE Compound Nitric oxide synthase, brain Source (NOS1_RAT) Sequence B:  RFLKVKNWETDVVLTDTLHLKSTLETGCTEHICMGSIVLP VRTKDQLFPLAKEFLDQYYSSIKRFGSKAHMDRLEEVNKE IESTSTYQLKDTELIYGAKHAWRNASRCVGRIQWSKLQVF DARDCTTAHGMFNYICNHVKYATNKGNLRSAITIFPQRTD GKHDFRVWNSQLIRYAGYKQPDGSTLGDPANVQFTEICIQ QGWKAPRGRFDVLPLLLQANGNDPELFQIPPELVLEVPIR HPKFDWFKDLGLKWYGLPAVSNMLLEIGGLEFSACPFSGW YMGTEIGVRNYCDNSRYNILEEVAKKMDLDMRKTSSLWKD QALVEINIAVLYSFQSDKVTIVDHHSATESFIKHMENEYR CRGGCPADWVWIVPPMSGSITPVFHQEMLNYRLTPSFEYQ PDPWNTHVWKG Description Functional site 1) chain B residue 676 type sequence W description BINDING SITE FOR RESIDUE H4B A 760 source : AC2 2) chain B residue 691 type sequence F description BINDING SITE FOR RESIDUE H4B A 760 source : AC2 3) chain B residue 692 type sequence H description BINDING SITE FOR RESIDUE H4B A 760 source : AC2 4) chain B residue 693 type sequence Q description BINDING SITE FOR RESIDUE H4B A 760 source : AC2 5) chain B residue 694 type sequence E description BINDING SITE FOR RESIDUE H4B A 760 source : AC2 6) chain B residue 306 type sequence W description BINDING SITE FOR RESIDUE JI5 A 800 source : AC3 7) chain B residue 326 type sequence C description BINDING SITE FOR RESIDUE ZN A 900 source : AC5 8) chain B residue 331 type sequence C description BINDING SITE FOR RESIDUE ZN A 900 source : AC5 9) chain B residue 409 type sequence W description BINDING SITE FOR RESIDUE HEM B 750 source : AC6 10) chain B residue 415 type sequence C description BINDING SITE FOR RESIDUE HEM B 750 source : AC6 11) chain B residue 584 type sequence F description BINDING SITE FOR RESIDUE HEM B 750 source : AC6 12) chain B residue 585 type sequence S description BINDING SITE FOR RESIDUE HEM B 750 source : AC6 13) chain B residue 587 type sequence W description BINDING SITE FOR RESIDUE HEM B 750 source : AC6 14) chain B residue 592 type sequence E description BINDING SITE FOR RESIDUE HEM B 750 source : AC6 15) chain B residue 704 type sequence F description BINDING SITE FOR RESIDUE HEM B 750 source : AC6 16) chain B residue 334 type sequence S description BINDING SITE FOR RESIDUE H4B B 760 source : AC7 17) chain B residue 336 type sequence V description BINDING SITE FOR RESIDUE H4B B 760 source : AC7 18) chain B residue 596 type sequence R description BINDING SITE FOR RESIDUE H4B B 760 source : AC7 19) chain B residue 677 type sequence V description BINDING SITE FOR RESIDUE H4B B 760 source : AC7 20) chain B residue 678 type sequence W description BINDING SITE FOR RESIDUE H4B B 760 source : AC7 21) chain B residue 336 type sequence V description BINDING SITE FOR RESIDUE JI5 B 800 source : AC8 22) chain B residue 414 type sequence R description BINDING SITE FOR RESIDUE JI5 B 800 source : AC8 23) chain B residue 478 type sequence Q description BINDING SITE FOR RESIDUE JI5 B 800 source : AC8 24) chain B residue 584 type sequence F description BINDING SITE FOR RESIDUE JI5 B 800 source : AC8 25) chain B residue 585 type sequence S description BINDING SITE FOR RESIDUE JI5 B 800 source : AC8 26) chain B residue 586 type sequence G description BINDING SITE FOR RESIDUE JI5 B 800 source : AC8 27) chain B residue 587 type sequence W description BINDING SITE FOR RESIDUE JI5 B 800 source : AC8 28) chain B residue 592 type sequence E description BINDING SITE FOR RESIDUE JI5 B 800 source : AC8 29) chain B residue 678 type sequence W description BINDING SITE FOR RESIDUE JI5 B 800 source : AC8 30) chain B residue 706 type sequence Y description BINDING SITE FOR RESIDUE JI5 B 800 source : AC8 31) chain B residue 587 type sequence W description BINDING SITE FOR RESIDUE ACT B 860 source : AC9 32) chain B residue 415 type BINDING sequence C description axial binding residue => ECO:0000250|UniProtKB:P29475 source Swiss-Prot : SWS_FT_FI2 33) chain B residue 334 type BINDING sequence S description BINDING => ECO:0000250|UniProtKB:P29475 source Swiss-Prot : SWS_FT_FI1 34) chain B residue 478 type BINDING sequence Q description BINDING => ECO:0000250|UniProtKB:P29475 source Swiss-Prot : SWS_FT_FI1 35) chain B residue 587 type BINDING sequence W description BINDING => ECO:0000250|UniProtKB:P29475 source Swiss-Prot : SWS_FT_FI1 36) chain B residue 588 type BINDING sequence Y description BINDING => ECO:0000250|UniProtKB:P29475 source Swiss-Prot : SWS_FT_FI1 37) chain B residue 592 type BINDING sequence E description BINDING => ECO:0000250|UniProtKB:P29475 source Swiss-Prot : SWS_FT_FI1 38) chain B residue 677 type BINDING sequence V description BINDING => ECO:0000250|UniProtKB:P29475 source Swiss-Prot : SWS_FT_FI1 39) chain B residue 678 type BINDING sequence W description BINDING => ECO:0000250|UniProtKB:P29475 source Swiss-Prot : SWS_FT_FI1 40) chain B residue 691 type BINDING sequence F description BINDING => ECO:0000250|UniProtKB:P29475 source Swiss-Prot : SWS_FT_FI1 41) chain B residue 706 type BINDING sequence Y description BINDING => ECO:0000250|UniProtKB:P29475 source Swiss-Prot : SWS_FT_FI1

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