eF-site ID 3jtl-ABCDEFGHIJKLMNOPQRSTU PDB Code 3jtl Chain A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U Title Crystal structure of archaeal 20S proteasome in complex with mutated P26 activator Classification HYDROLASE/HYDROLASE ACTIVATOR Compound Proteasome subunit alpha Source Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165) (Q9U8G2_9TRYP) Sequence A:  AYDRAITVFSPDGRLFQVEYAREAVKKGSTALGMKFANGV LLISDKKVRSRLIEQNSIEKIQLIDDYVAAVTSGLVADAR VLVDFARISAQQEKVTYGSLVNIENLVKRVADQMQQYTQY GGVRPYGVSLIFAGIDQIGPRLFDCDPAGTINEYKATAIG SGKDAVVSFLEREYKENLPEKEAVTLGIKALKSSLEEGEE LKAPEIASITVGNKYRIYDQEEVKKFL B:  AYDRAITVFSPDGRLFQVEYAREAVKKGSTALGMKFANGV LLISDKKVRSRLIEQNSIEKIQLIDDYVAAVTSGLVADAR VLVDFARISAQQEKVTYGSLVNIENLVKRVADQMQQYTQY GGVRPYGVSLIFAGIDQIGPRLFDCDPAGTINEYKATAIG SGKDAVVSFLEREYKENLPEKEAVTLGIKALKSSLEEGEE LKAPEIASITVGNKYRIYDQEEVKKFL C:  AYDRAITVFSPDGRLFQVEYAREAVKKGSTALGMKFANGV LLISDKKVRSRLIEQNSIEKIQLIDDYVAAVTSGLVADAR VLVDFARISAQQEKVTYGSLVNIENLVKRVADQMQQYTQY GGVRPYGVSLIFAGIDQIGPRLFDCDPAGTINEYKATAIG SGKDAVVSFLEREYKENLPEKEAVTLGIKALKSSLEEGEE LKAPEIASITVGNKYRIYDQEEVKKFL D:  AYDRAITVFSPDGRLFQVEYAREAVKKGSTALGMKFANGV LLISDKKVRSRLIEQNSIEKIQLIDDYVAAVTSGLVADAR VLVDFARISAQQEKVTYGSLVNIENLVKRVADQMQQYTQY GGVRPYGVSLIFAGIDQIGPRLFDCDPAGTINEYKATAIG SGKDAVVSFLEREYKENLPEKEAVTLGIKALKSSLEEGEE LKAPEIASITVGNKYRIYDQEEVKKFL E:  AYDRAITVFSPDGRLFQVEYAREAVKKGSTALGMKFANGV LLISDKKVRSRLIEQNSIEKIQLIDDYVAAVTSGLVADAR VLVDFARISAQQEKVTYGSLVNIENLVKRVADQMQQYTQY GGVRPYGVSLIFAGIDQIGPRLFDCDPAGTINEYKATAIG SGKDAVVSFLEREYKENLPEKEAVTLGIKALKSSLEEGEE LKAPEIASITVGNKYRIYDQEEVKKFL F:  AYDRAITVFSPDGRLFQVEYAREAVKKGSTALGMKFANGV LLISDKKVRSRLIEQNSIEKIQLIDDYVAAVTSGLVADAR VLVDFARISAQQEKVTYGSLVNIENLVKRVADQMQQYTQY GGVRPYGVSLIFAGIDQIGPRLFDCDPAGTINEYKATAIG SGKDAVVSFLEREYKENLPEKEAVTLGIKALKSSLEEGEE LKAPEIASITVGNKYRIYDQEEVKKFL G:  AYDRAITVFSPDGRLFQVEYAREAVKKGSTALGMKFANGV LLISDKKVRSRLIEQNSIEKIQLIDDYVAAVTSGLVADAR VLVDFARISAQQEKVTYGSLVNIENLVKRVADQMQQYTQY GGVRPYGVSLIFAGIDQIGPRLFDCDPAGTINEYKATAIG SGKDAVVSFLEREYKENLPEKEAVTLGIKALKSSLEEGEE LKAPEIASITVGNKYRIYDQEEVKKFL H:  TTTVGITLKDAVIMATERRVTMENFIMHKNGKKLFQIDTY TGMTIAGLVGDAQVLVRYMKAELELYRLQRRVNMPIEAVA TLLSNMLNQVKYMPYMVQLLVGGIDTAPHVFSIDAAGGSV EDIYASTGSGSPFVYGVLESQYSEKMTVDEGVDLVIRAIS AAKQRDSASGGMIDVAVITRKDGYVQLPTDQIESRIRKLG LIL I:  TTTVGITLKDAVIMATERRVTMENFIMHKNGKKLFQIDTY TGMTIAGLVGDAQVLVRYMKAELELYRLQRRVNMPIEAVA TLLSNMLNQVKYMPYMVQLLVGGIDTAPHVFSIDAAGGSV EDIYASTGSGSPFVYGVLESQYSEKMTVDEGVDLVIRAIS AAKQRDSASGGMIDVAVITRKDGYVQLPTDQIESRIRKLG LIL J:  TTTVGITLKDAVIMATERRVTMENFIMHKNGKKLFQIDTY TGMTIAGLVGDAQVLVRYMKAELELYRLQRRVNMPIEAVA TLLSNMLNQVKYMPYMVQLLVGGIDTAPHVFSIDAAGGSV EDIYASTGSGSPFVYGVLESQYSEKMTVDEGVDLVIRAIS AAKQRDSASGGMIDVAVITRKDGYVQLPTDQIESRIRKLG LIL K:  TTTVGITLKDAVIMATERRVTMENFIMHKNGKKLFQIDTY TGMTIAGLVGDAQVLVRYMKAELELYRLQRRVNMPIEAVA TLLSNMLNQVKYMPYMVQLLVGGIDTAPHVFSIDAAGGSV EDIYASTGSGSPFVYGVLESQYSEKMTVDEGVDLVIRAIS AAKQRDSASGGMIDVAVITRKDGYVQLPTDQIESRIRKLG LIL L:  TTTVGITLKDAVIMATERRVTMENFIMHKNGKKLFQIDTY TGMTIAGLVGDAQVLVRYMKAELELYRLQRRVNMPIEAVA TLLSNMLNQVKYMPYMVQLLVGGIDTAPHVFSIDAAGGSV EDIYASTGSGSPFVYGVLESQYSEKMTVDEGVDLVIRAIS AAKQRDSASGGMIDVAVITRKDGYVQLPTDQIESRIRKLG LIL M:  TTTVGITLKDAVIMATERRVTMENFIMHKNGKKLFQIDTY TGMTIAGLVGDAQVLVRYMKAELELYRLQRRVNMPIEAVA TLLSNMLNQVKYMPYMVQLLVGGIDTAPHVFSIDAAGGSV EDIYASTGSGSPFVYGVLESQYSEKMTVDEGVDLVIRAIS AAKQRDSASGGMIDVAVITRKDGYVQLPTDQIESRIRKLG LIL N:  TTTVGITLKDAVIMATERRVTMENFIMHKNGKKLFQIDTY TGMTIAGLVGDAQVLVRYMKAELELYRLQRRVNMPIEAVA TLLSNMLNQVKYMPYMVQLLVGGIDTAPHVFSIDAAGGSV EDIYASTGSGSPFVYGVLESQYSEKMTVDEGVDLVIRAIS AAKQRDSASGGMIDVAVITRKDGYVQLPTDQIESRIRKLG LIL O:  KRAALIQNLRDSYTETSSFAVIEEWAAGTLQEIEGIAKAA AEAHGVIRNSTYGRAQAEKSPEQLLGVLQRYQDLCHNVYC QAETIRTVIAIRIPEHKEEDNLGVAVQHAVLKIIDELEIK TLGSGEKSGSGGAPTPIGMYALREYLSARSTVEDKLLGGG SQSPSLLLELRQIDADFMLKVELATTHLSTMVRAVINAYL LNWKKLIQPRTHLDVLYR P:  KRAALIQNLRDSYTETSSFAVIEEWAAGTLQEIEGIAKAA AEAHGVIRNSTYGRAQAEKSPEQLLGVLQRYQDLCHNVYC QAETIRTVIAIRIPEHKEEDNLGVAVQHAVLKIIDELEIK TLGSGEKSGSGGAPTPIGMYALREYLSARSTVEDKLLGGG SQSPSLLLELRQIDADFMLKVELATTHLSTMVRAVINAYL LNWKKLIQPRTHLDVLYR Q:  KRAALIQNLRDSYTETSSFAVIEEWAAGTLQEIEGIAKAA AEAHGVIRNSTYGRAQAEKSPEQLLGVLQRYQDLCHNVYC QAETIRTVIAIRIPEHKEEDNLGVAVQHAVLKIIDELEIK TLGSGEKSGSGGAPTPIGMYALREYLSARSTVEDKLLGGG SQSPSLLLELRQIDADFMLKVELATTHLSTMVRAVINAYL LNWKKLIQPRTHLDVLYR R:  KRAALIQNLRDSYTETSSFAVIEEWAAGTLQEIEGIAKAA AEAHGVIRNSTYGRAQAEKSPEQLLGVLQRYQDLCHNVYC QAETIRTVIAIRIPEHKEEDNLGVAVQHAVLKIIDELEIK TLGSGEKSGSGGAPTPIGMYALREYLSARSTVEDKLLGGG SQSPSLLLELRQIDADFMLKVELATTHLSTMVRAVINAYL LNWKKLIQPRTHLDVLYR S:  KRAALIQNLRDSYTETSSFAVIEEWAAGTLQEIEGIAKAA AEAHGVIRNSTYGRAQAEKSPEQLLGVLQRYQDLCHNVYC QAETIRTVIAIRIPEHKEEDNLGVAVQHAVLKIIDELEIK TLGSGEKSGSGGAPTPIGMYALREYLSARSTVEDKLLGGG SQSPSLLLELRQIDADFMLKVELATTHLSTMVRAVINAYL LNWKKLIQPRTHLDVLYR T:  KRAALIQNLRDSYTETSSFAVIEEWAAGTLQEIEGIAKAA AEAHGVIRNSTYGRAQAEKSPEQLLGVLQRYQDLCHNVYC QAETIRTVIAIRIPEHKEEDNLGVAVQHAVLKIIDELEIK TLGSGEKSGSGGAPTPIGMYALREYLSARSTVEDKLLGGG SQSPSLLLELRQIDADFMLKVELATTHLSTMVRAVINAYL LNWKKLIQPRTHLDVLYR U:  KRAALIQNLRDSYTETSSFAVIEEWAAGTLQEIEGIAKAA AEAHGVIRNSTYGRAQAEKSPEQLLGVLQRYQDLCHNVYC QAETIRTVIAIRIPEHKEEDNLGVAVQHAVLKIIDELEIK TLGSGEKSGSGGAPTPIGMYALREYLSARSTVEDKLLGGG SQSPSLLLELRQIDADFMLKVELATTHLSTMVRAVINAYL LNWKKLIQPRTHLDVLYR Description Functional site 1) chain H residue 1 type ACT_SITE sequence T description Nucleophile => ECO:0000255|HAMAP-Rule:MF_02113, ECO:0000269|PubMed:7725107 source Swiss-Prot : SWS_FT_FI1 2) chain I residue 1 type ACT_SITE sequence T description Nucleophile => ECO:0000255|HAMAP-Rule:MF_02113, ECO:0000269|PubMed:7725107 source Swiss-Prot : SWS_FT_FI1 3) chain J residue 1 type ACT_SITE sequence T description Nucleophile => ECO:0000255|HAMAP-Rule:MF_02113, ECO:0000269|PubMed:7725107 source Swiss-Prot : SWS_FT_FI1 4) chain K residue 1 type ACT_SITE sequence T description Nucleophile => ECO:0000255|HAMAP-Rule:MF_02113, ECO:0000269|PubMed:7725107 source Swiss-Prot : SWS_FT_FI1 5) chain L residue 1 type ACT_SITE sequence T description Nucleophile => ECO:0000255|HAMAP-Rule:MF_02113, ECO:0000269|PubMed:7725107 source Swiss-Prot : SWS_FT_FI1 6) chain M residue 1 type ACT_SITE sequence T description Nucleophile => ECO:0000255|HAMAP-Rule:MF_02113, ECO:0000269|PubMed:7725107 source Swiss-Prot : SWS_FT_FI1 7) chain N residue 1 type ACT_SITE sequence T description Nucleophile => ECO:0000255|HAMAP-Rule:MF_02113, ECO:0000269|PubMed:7725107 source Swiss-Prot : SWS_FT_FI1 8) chain A residue 8-30 type prosite sequence YDRAITVFSPDGRLFQVEYAREA description PROTEASOME_ALPHA_1 Proteasome alpha-type subunits signature. YdraiTvFSPdGRlfQVEYAreA source prosite : PS00388 9) chain H residue 4-51 type prosite sequence VGITLKDAVIMATERRVTMENFIMHKNGKKLFQIDTYTGM TIAGLVGD description PROTEASOME_BETA_1 Proteasome beta-type subunits signature. VGItLkdAVIMATErrvtmenfimhkngk.KlfqidtytgmtiaGlvGD source prosite : PS00854

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