eF-site ID 3jsd-ABCD PDB Code 3jsd Chain A, B, C, D click to enlarge Title Insulin's biosynthesis and activity have opposing structural requirements: a new factor in neonatal diabetes mellitus Classification HORMONE Compound Insulin A chain Source Homo sapiens (Human) (INS_HUMAN) Sequence A:  GIVEQCCTSICSLYQLENYCN B:  FVNQHLCXSHLVEALYLVCGERGFFYTPKT C:  GIVEQCCTSICSLYQLENYCN D:  FVNQHLCXSHLVEALYLVCGERGFFYTPKT Description Functional site 1) chain B residue 10 type sequence H description BINDING SITE FOR RESIDUE ZN B 31 source : AC1 2) chain B residue 10 type sequence H description BINDING SITE FOR RESIDUE ZN B 31 source : AC1 3) chain B residue 10 type sequence H description BINDING SITE FOR RESIDUE ZN B 31 source : AC1 4) chain B residue 10 type sequence H description BINDING SITE FOR RESIDUE CL B 32 source : AC2 5) chain B residue 10 type sequence H description BINDING SITE FOR RESIDUE CL B 32 source : AC2 6) chain B residue 10 type sequence H description BINDING SITE FOR RESIDUE CL B 32 source : AC2 7) chain C residue 6 type sequence C description BINDING SITE FOR RESIDUE IPH C 200 source : AC3 8) chain C residue 9 type sequence S description BINDING SITE FOR RESIDUE IPH C 200 source : AC3 9) chain C residue 10 type sequence I description BINDING SITE FOR RESIDUE IPH C 200 source : AC3 10) chain C residue 11 type sequence C description BINDING SITE FOR RESIDUE IPH C 200 source : AC3 11) chain D residue 5 type sequence H description BINDING SITE FOR RESIDUE IPH C 200 source : AC3 12) chain D residue 11 type sequence L description BINDING SITE FOR RESIDUE IPH C 200 source : AC3 13) chain D residue 10 type sequence H description BINDING SITE FOR RESIDUE ZN D 31 source : AC4 14) chain D residue 10 type sequence H description BINDING SITE FOR RESIDUE ZN D 31 source : AC4 15) chain D residue 10 type sequence H description BINDING SITE FOR RESIDUE ZN D 31 source : AC4 16) chain D residue 10 type sequence H description BINDING SITE FOR RESIDUE CL D 32 source : AC5 17) chain D residue 10 type sequence H description BINDING SITE FOR RESIDUE CL D 32 source : AC5 18) chain D residue 10 type sequence H description BINDING SITE FOR RESIDUE CL D 32 source : AC5 19) chain A residue 6-20 type prosite sequence CCTSICSLYQLENYC description INSULIN Insulin family signature. CCTSiCSlyqLenyC source prosite : PS00262

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