|
|
eF-site ID
|
3jbl-E |
|
PDB Code
|
3jbl |
|
Chain
|
E |
|
click to enlarge
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Title
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Cryo-EM Structure of the Activated NAIP2/NLRC4 Inflammasome Reveals Nucleated Polymerization |
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Classification
|
IMMUNE SYSTEM |
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Compound
|
NLR family CARD domain-containing protein 4 |
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Source
|
(NLRC4_MOUSE) |
|
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Sequence
|
E: |
VTEEDLNVLAQNLKDLYNSPAFLNFYPLGEDIDIIFNLEK
TFTEPIMWKKDHRHHRVEQLTLGSLLEALKSPCLIEGESG
KGKSTLLQRIAMLWASGGCRALKGFRLVFFIHLRSARGGL
FETLYDQLLNIPDFISKPTFKALLLKLHKEVLFLLDGYNE
FHPQNCPEIEALIKENHRFKNMVIVTTTTECLRHIRHVGA
LTAEVGDMTEDSAKDLIEAVLVPDQVERLWAQIQESRCLR
NLMKTPLFVVITCAIQMGRQEFQAHTQTMLFQTFYDLLIQ
KNSHRYRGGASGDFARSLDYCGDLALEGVFAHKFDFEPEH
GSSMNEDVLVTIGLLCKYTAQRLKPTYKFFHKSFQEYTAG
RRLSSLLTSKEPEEVSKGNSYLNKMVSISDITSLYGNLLL
YTCGSSTEATRAVMRHLAMVYQHGSLQGLSVTKRPLWRQE
XIQSLRNTTEQDVLKAINVNSFVECGINLFSESMSKSDLS
QEFEAFFQGKSLYINSENIPDYLFDFFEYLPNCASALDFV
KLDFYERATPPRAVSLFFNWKQEFKTLEVTLRDINKLNKQ
DIKYLGKIFSSATNLRLHIKRCAAMAGRLSSVLRTCKNMH
TLMVEASPLTTDDEQYITSVTGLQNLSIHRLHTQQLPGGL
IDSLGNLKNLERLILDDIRMNEEDAKNLAEGLRSLKKMRL
LHLTHLSDIGEGMDYIVKSLSEESCDLQEMKLVACCLTAN
SVKVLAQNLHNLIKLSILDISENYLEKDGNEALQELIGRL
GVLGELTTLMLPWCWDVHTSLPKLLKQLEGTPGLAKLGLK
NWRLRDEEIKSLGEFLEMNPLRDLQQLDLAGHCVSSDGWL
YFMNVFENLKQLVFFDFSTEEFLPDAALVRKLSQVLSKLT
LLQEVKLTGWEFDDYDISAIKGTFKLVTA
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Description
|
(1) |
NLR family CARD domain-containing protein 4
|
|
Functional site
|
|
|
1)
|
chain |
E |
| residue |
135 |
| type |
BINDING |
| sequence |
T
|
| description |
BINDING => ECO:0000269|PubMed:23765277, ECO:0007744|PDB:4KXF
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
2)
|
chain |
E |
| residue |
172 |
| type |
BINDING |
| sequence |
G
|
| description |
BINDING => ECO:0000269|PubMed:23765277, ECO:0007744|PDB:4KXF
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
3)
|
chain |
E |
| residue |
443 |
| type |
BINDING |
| sequence |
H
|
| description |
BINDING => ECO:0000269|PubMed:23765277, ECO:0007744|PDB:4KXF
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
4)
|
chain |
E |
| residue |
533 |
| type |
MOD_RES |
| sequence |
X
|
| description |
Phosphoserine => ECO:0000269|PubMed:22885697, ECO:0000269|PubMed:23765277
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
|