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Title
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Cryo-EM structure of the yeast spliceosome at 3.6 angstrom resolution |
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Classification
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RNA BINDING PROTEIN/RNA |
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Compound
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Pre-mRNA-splicing factor spp42 |
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Source
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ORGANISM_COMMON: Fission yeast; ORGANISM_SCIENTIFIC: Schizosaccharomyces pombe 972h-; |
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Sequence
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A: |
LEKQLNERARKWRASQKSKFGVKRKQGYVQTEKADLPPEH
LRKIMKDRGDMSSRKFRADKRSYLGALKYLPHAVLKLLEN
MPMPWEEYREVKVLYHVTGAITFVNESPRVIEPHFIAQWG
TMWMMMRREKRDRKNFKRLRFPPFDDEEPPFSIDQLLDLE
PLEAIRMDLDEEDDAPVMDWFYENKALEDTPHVNGPTYRR
WKLNLPQMANLHRLGYQLLSDLRDDNYFYLFNDNSFFTAK
ALNVAIPGGPKFEPLYEFNDIYKLIIRHPIKTEYRIAFPY
LYNSRARSVALSEYHQPSNVFVPPEDPDLPAFFWDPIINP
ITSRQLTLHELDTSPEDSAIEEDPNFEIPFDPFFHSEDIE
FEHTASALILLWAPHPFNKRSGATKRAQDVPLIKHWYLEH
CPPNQPVKVRVSYQKLLKSHVMNKLHMAHPKSHTNRSLLR
QLKNTKFFQSTSIDWVEAGLQVCRQGYNMLQLLIHRKGLT
YLHLDYNCNLKPTKTLTTKERKKSRFGNAFHLMREILRLT
KLIVDSHVQYRLGNIDAYQLADGLHYIFNHVGQLTGMYRY
KYRLMRQIRACKDFKHLIYYRFNTGPVGKGPGCGFWAPSW
RVWLFFLRGIVPLLERWLGNLLARQFEGRHSTGVAKQITK
QRVDSHQDLELRAAVMNDILDMIPEGIRQGKSKTILQHLS
EAWRCWKANIPWKVPGLPAPIENMILRYVKSKADWWTSVA
HFNRERIRRGATVDKTVAKKNLGRLTRLWLKAEQERQHNY
LKDGPYVTADEAVAIYTTFVHWLESRRFQPIPFPPLSYKH
DTKLLVLALERLKEAYSVKGRLNQSQREELALVEQAYDNP
HEMLSQIKRRLLTMRTFKEVGIEFMDMYSHLIPVYSVDPM
EKICDAYLDQYLWFEADRRHLFPSWVKPSDSEPPPLLVYK
WCQGINNLTDVWETSNGECNVLMETRLSKVFEKVDLTLLN
RLMSLLMDTNLASYASAKNNVVLSYKDMSHTNSYGLVRGL
QFSSFIWQFYGLVLDLLILGLQRATEIAGPADAPNDFLHF
KDQATETSHPIRLYTRYIDKVYIMFRFTDEESRDLIQRFL
NENPDPTNSNVVNYSKGKKNCWPRDARMRLMKHDVNLGRA
VFWEIRNRLPRSLTTLEWEDTFPSVYSKDNPNLLFSMTGF
EVRILPKIRQNEEFSLKDGVWNLTDNRTKQRTAQAFIRVT
EDGINQFGNRIRQILMSSGSTTFTKIANKWNTALIALMTY
YREAAISTPELLDLLVKCESKIQTRVKISLNSKMPSRFPP
AVFYSPKELGGLGMLSMGHVLIPQSDLRWSKQTDTGITHF
RSGMTTNGEHLIPNLYRYIQPWESEFIDSQRVWAEYAMKR
QEALQQNRRLTLEDLEDSWDRGIPRINTLFQKDRHTLAYD
KGWRVRTEFKQYQLLKNNPFWWTSQRHDGKLWQLNNYRVD
VIQALGGVEGILEHTMFKATGFPSWEGLFWEKASGFKKLT
NAQRSGLNQIPNRRFTLWWSPTINRANVYVGFQVQLDLTG
IMMHGKIPTLKISLIQIFRSHLWQKIHESVVWDLCQVLDQ
ELESLQIETVQKETIHPRKSYKMNSSCADILLLAAYKWNV
SRPSLLNDNRDVLDNTTTNKYWIDVQLRFGDYDSHDIERY
TRAKFLDYSTDAQSMYPSPTGVLIGIDLCYNMHSAYGNWI
PGMKPLIQQSMNKIMKANPALYVLRERIRKGLQLYASEQY
LSSSNYAELFSNQIQLFVDDTNVYRVTIHKTFEGNLTTKP
INGAIFIFNPRTGQLFLKVIHTSVWAGQKRLGQLAKWKTA
EEVAALIRSLPVEEQPRQIIVTRKGMLDPLEVHLLDFPNI
TIKGSELQLPFQAIIKLDKINDLILRATEPQMVLFNLYDD
WLQSVSSYTAFSRLILILRALNVNTEKTKLILRPDKSIIT
KENHVWPNLDDQQWLDVEPKLRDLILADYAKKNNINVASL
TNSE
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| B: |
AVVLHEDKQYYPSAEEVYGSNVDIMVQEQDTQPLSQPIIE
PIRHKRIAIETTNVPDTVYKKEFLFGLLTGTDDVRSFIVA
GHLHHGKSALLDLLVYYTHPDTKPPKRRSLRYTDTHYLER
ERVMSIKSTPLTLAVSDMKGKTFAFQCIDTPGHVDFVDEV
AAPMAISDGVVLVVDVIEGVMINTTRIIKHAILHDMPIVL
VLNKVDRLILELRLPPNDAYHKLRHVIDEVNDNICQISKD
LKYRVSPELGNVCFASCDLGYCFTLSSFAKLYIDRHGGID
VDLFSKRLWGDIYFDSKTRKFAKQSLDGSGVRSFVHFILE
PLYKLHTLTISDEAEKLKKHLSSFQIYLKPKDYLLDPKPL
LQLICASFFGFPVGFVNAVTRHIPSPRENAARKASQSYIG
PINSSIGKAILEMSREESAPLVMHVTKLYNTVDANNFYAF
ARVYSGQVKKGQKVKVLGENYSLEDEEDMVVAHIAEICVP
CARYRLHVDGAVAGMLVLLGGVDNSISKTATIVSDNLKDD
PYIFRPIAHMSESVFKVAVEPHNPSELPKLLDGLRKTNKS
YPLSITKVEESGEHTIFGTGEMYMDCLLYDLRTLYSEIEI
RVSDPVARFCETAVDTSSIKCFSDTPNKKNRITMVVEPLE
KGISNDIENGKVNINWPQKRISEFFQKNYDWDLLASRSIW
AFGPDDRGTNILRDDTLSTDVDKNVLNSVKEYIKQGFQWG
TREGPLCDETIRNVNFRLMDVVLAPEQIYRGGGQIIPTAR
RVCYSSFLTASPRLMEPVYMVEVHAPADSLPIIYDLLTRR
RGHVLQDIPRPGSPLYLVRALIPVIDSCGFETDLRVHTQG
QAMCQMVFDHWQVVPGDPLDKSIKPKPLEPARGSDLARDF
LIKTRRRKGLVEDVSTTRYFDQEM
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| D: |
SLCIKLLHETQGHIVTMELENGSTYRGKLIEAEDNMNCQM
RDISVTARDGRVSHLDQVYIRGSHIRFLIVPDMLRNAPMF
KVGPGRSVPLPTRGRR
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| E: |
GTTKMVSLLNHSLNVTTKDGRTFVGQLLAFDGFMNLVLSD
CQEYRHEEKRMLGLVILRGEFIVSLSVQGPPPMLLSGPGV
ARPAGRGIPLGQAPVGLA
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| F: |
MKLVRFLMKLTNETVSIELKNGTIVHGTITSVDMQMNTHL
KAVKMTVKGREPVPVETLSIRGNNIRYYILPDSLPLDTLL
ID
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| G: |
RLEEYEFSAGPLSVLQQAVKNHDQVLINCRNNKKLLARVK
AFDRHSNMVLENVKEMWTEKKRTASGGKAINKDRFISKMF
LRGDGVVLVVRIPSA
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| H: |
MIPPINFIFKLLQQHTPVSIWLFEQTDIRLQGQIRGFDEF
MNIVLDDAVQVDAKNNKRELGRILLKGDNITLIQAI
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| I: |
VPVNPKPFLQGLIGKPVLVRLKWGQEYKGTLQSVDSYMNL
QLLNAEELVDGVKTGDLGEILIRCNNVLWVGEV
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| J: |
KAGAPDLKKYLDRQVFVQLNGSRKVYGVLRGYDIFLNIVL
EDSIEEKVDGEKVKIGSVAIRGNSVIMIETLDK
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| K: |
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXWHAPWTLMRVISGHLGWVRCVDVEPGNQW
FCTGAGDRTIKIWDLASGVLKLTLTGHIATVRGLAVSPRH
PYLFSCGEDKMVKCWDLETNKVIRHYHGHLSGVYALKLHP
TLDVLVTAGRDAVARVWDMRTRQNVHVLSGHKSTVASLAV
QEFDPQVVTGSMDSTIRLWDLAAGKTLTTLTHHKKTVRAL
SLHPDEFTFASGSSDNIKHWKFPEGAFMGNFEGHNAIVNT
LSINSDNVMFSGADNGSMCFWDWKSGHKYQELQSVVQPGS
LDSEAGIFASSFDKTGLRLITCEADKSVKIYKQVDNATPE
THPNLPWTPSNLR
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| L: |
PNLQMFGHTAEVLVARFDPSGSYFASGGMDRQILLWNVFD
VKNYGVLNGCKGAITDLQWSRDSRVVYCSSSDTHLMSWDA
VSGQKIRKHKGHAGVVNALDVLKVSELLTSVSDDCTMKVW
DSRSKDCIKTIEEKYPLTAVAIAQQGTQVFIGGIDGAIKI
WDLRNNHCSHVLKGHKDIITSLAISKDGSSLLSNSMDNTV
RIFDVKAQRQLQIFEGAIHGQEHNLLGVAWSRNSRFVGAG
SSDKNVYVWSATGDLRYVLPGHEGSVNHVDFHPHQDIILS
CSSDRTIFLGELN
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| M: |
AVDYNAIARQGHEHGELVQASFRDLIPLRARLGVGEISLE
KPSDEQKQEVANKTKLALQKILSKQIAQSQPKSAVVQQRD
DPVYIRYTPSNQMGQALSKQRIIKMVTAEQDPMEPPKFRH
KKVPRGPPSPPPPVLHSPPRKVSAQEQQDWQIPPSISNWK
NPKGYTIPLDKRDVEINDGFAKFSEALYTVERQAREEVRY
RAIMRQK
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| R: |
XXXXXXXXXXXXXXXXNITDLEELQEFQGRKRKEFEDAIR
RNRLAMGHWMRYGQWELDQKEFARARSVFERALDVDSTYI
PLWLKYIECEMKNRNINHARNLFDRAVTQLPRVDKLWYKY
VYMEEMLGNITGCRQVFERWLKWEPDENCWMSYIRMERRY
HENERARGIYERFVVVHPEVTNWLRWARFEEECGNAANVR
QVYLAAIDALGQEFLNERFFIAFAKFEIRQKEYERARTIF
KYAIDFMPRSKSMELYKEYTHFEKQFXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXX
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| S: |
MFCSISGETPKEPVISRVSGNVYEKRLIEQVIRETSKDPV
TQQECTLEDLVPVKVPDFVRPRPPSATSLPALLSLFQEEW
DSVALEQFELRRNLTETKQELSTALYSLDAALRVISRLTK
ERDEAREALAKF
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| T: |
MFCSISGETPKEPVISRVSGNVYEKRLIEQVIRETSKDPV
TQQECTLEDLVPVKVPDFVRPRPPSATSLPALLSLFQEEW
DSVALEQFELRRNLTETKQELSTALYSLDAALRVISRLTK
ERDEAREALAKFSD
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| U: |
MFCSISGETPKEPVISRVSGNVYEKRLIEQVIRETSKDPV
TQQECTLEDLVPVKVPDFVRPRPPSATSLPALLSLFQEEW
DSVALEQFELRRNLTETKQELSTALYSLDAALRVISRLTK
ERDEAREALAKFSDNLSSKRKRTKLQPKWATDDAVSQLLQ
ATPSTILENLETESTTSFFPSPENSSFVLCLHKDELLCLD
IQSEGSALACCWLTSSKIAVATADAISIFEFPVSSSGLQS
VGEIDEKVNFLQAHPSGEYLLAASNEKCYIFSKSQVYNIT
VAQHITSLAVHPDGNLFVAGLENGELRFFETSSGNELTKF
GPHSSPVKTLQFGENGYWLVVTTNSDIFIWDLRKSELVQK
IPLQTKVAAVSLDITQLLVSSDGETLYVHIYVKSRCMSQT
HVSSISNLVWLNELHQLLFSTSNGAILRLG
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| V: |
MFCSISGETPKEPVISRVSGNVYEKRLIEQVIRETSKDPV
TQQECTLEDLVPVKVPDFVRPRPPSATSLPALLSLFQEEW
DSVALEQFELRRNLTETKQELSTALYSLDAALRVISRLTK
ERDEAREALAK
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| W: |
AWKNTEDEILKAAVSKYGKNQWARISSLLVRKTPKQCKAR
WYEWIDPSIKKTEWSREEDEKLLHLAKLLPTQWRTIAPIV
GRTATQCLERYQKLLDDLEAKEDMDEDEKEMLSEARARLA
NTQGKKAKRKDREKQLELTRRLSHLQKRRELKYNASIPFE
KKPAIGFYXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
AAEKFYTNDIQRDLAKKALECNKLENRVYDLVRSSYEQRN
FLIKKISHAWKALQTERKNLTCYEFLYNQERLALPNRLEA
AEIELSKMQQIEAYAQQDYARVTGQN
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| X: |
KKKQIINYANSNWGEGVEFQETMLQCILEAVIVSAKQVLS
LLHELKLFENFLWQRVNTEMSLNHINLTCMLLLYKSKYEY
ITWDLINRFQLFFEKVIEVSLSLNLSEVVYMIQFITLCFQ
FSNIEKLRKLVYQLTNISILNSLLDKVKYLLHDSSSLTKA
FDSYKEKRPVEKFPLHNLLSRWIHSLLIKSISYAQKQEAK
VTPLLAIINMSLVLLSAFPTRRFAHPVIEDSCFYTALRMS
LYYDSNELFKKMTDDLNYVLKFPFDNTRGNEYEKEQKIRN
DELVYYHLQLTLFSDFQLQQRQKLEEITSFLSFNSLKSLC
SKCYLRTSFPEKYAIKVDFEFLKNVFINTYDRRLVNDYDE
IINFTLKDVLGERSVMDQENSLTNTAIQYLSISFFMRQQS
KAYKKLLLRSLYAELLNFSEQYRRLSIKNATKNLNFFSLN
NFKVTSVAPLPQFVKCQMGLSRPSALRDLKNSSPFLCLIY
ISKDMEYKLLHGNALDPLEVTDFTIATICNDDVGMFMQSD
SDNKSINVYLSPFYYHSLAGLGEYRPKQLKFNFALVLSNK
YWLDLNILVSLLNRAKEFPKWFEDLFLGFGTPDICAFPNA
NSIYARNLFNTVEQLQSVLPNCHVPSNLSTESLLIKFYTN
QNKSADVTASDRHFSNRLYTYNDKQLESILRGSQPGLTMV
NGPTRCGKHVLVCKLLEVLQDTSPNDRTVVLSDSNFSMNT
LFTLLEKARCFHHLLYLSDEGTLERYGTLSSWISKLPGLL
REIGRLAASIQAPGSHDASPDTALYFRDAYIKRLWEKYLN
TVDKDSVDAYNRFPFHSYFGDKSKRPIETYNKDNFFDYAT
KLYGELEYMFQQLEEIRPFGLLRYYEDQELYALCQQSRII
GCTWTSLSTRLGTLKEKGFCFNNLIVMNSQNISESSITSI
LLSNCEPTGFDRLVLLGNQYNGSLFKRLRYLKSRIIDLNT
QYNVRESISSLCSSIYPLDIKTVDSSPNKRLDYGNSGFAH
EVQFINVGAFKGSQETEPVSGYKQNLGEAEYAVALFQYMR
MLGYPTNEIVICTLYESQVSLLNEIISVRCSHNSFFGQPA
FVGTVEKLPKRVNFVIFTTVESKEASDHWNPKTFYKAFSA
CSYGLYVLCNRDLFRSTRGLEKLWNEIEKTPDKLLLTTGE
IYPSSHSSVETFEIENLLHLSNYVVEMTKKRLNTN
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| Y: |
PARKQIETRPEYEMEPEQPGQVYNLWYNKWSGGMRQDPLK
SQVKSETRCVISRDSGYTKADKNPGSFFCLYFARGMCSEG
SKCEYLHRLPKDTDFFNANVDCFGREKHADYRDDMGGVGS
FLRQNYTLYVGGITPTDDIEEIVSRHFAEWGDIERIRVLN
SRGIAFITYLNEANAQFAKEAMAHQSLECLNVRWATTDPN
PASQARNQRRLEERAANAVKKLLPKQFLLDLEETKNGKXX
XXXXXXXXXXXXXXXXXXXXX
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| Z: |
SLCIKLLHETQGHIVTMELENGSTYRGKLIEAEDNMNCQM
RDISVTARDGRVSHLDQVYIRGSHIRFLIVPDMLRNAPMF
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| a: |
EFPSICERCLGDNSYVRMTKEPLGQECKICSKPCTIFRWI
KERGQKPGKTQICVGCARYKNCCQSCMLDLQFGLPIALRD
AALKLVESGPTNDINREFFAQNQQRLLSNGETAYDSQEAS
AAARNLVKKVEKREXXXXXXXXXXXXXXASLNAERADYKI
RKHFEQYGPLKSVVCSHRAKCAFVNFKTRSSAEIAAAASP
DGNVLKVQWGKXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXX
|
| b: |
GTTKMVSLLNHSLNVTTKDGRTFVGQLLAFDGFMNLVLSD
CQEYRHEEKRMLGLVILRGEFIVSLSVQGPPPMD
|
| c: |
PTIDEMVQEEKLLNKQRKYGQNYEYAKQIAKDKTYSNNLD
YLDENAGKLSNRMKRGDVSLAQISSGGDLKKINHVLDTCP
LCLNYETQPLAPVISLSHRAYVSLPTQPELAKYHCLIVPT
GHRINTLSCDEDEWDEIRNFMKCIALMFDSMNLGVIFYEN
APSPQRYMHTAIECIPVSKRILSLAPAYFREALSTSDEEW
SQHRKIIDTLEGSKKYGKWAFRKMMVKELGYFHVWFSIDG
GYGHVVEDEKAWGRHDQVPRQVFASMLNLPPEVIRRKGSW
TGKKDPREDMFRSRFEKFDW
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| d: |
MANVELQTSLGKILIELYTEHAPKTCQNFYTLAKEGYYDG
VIFHRVIPDFVIQGGDPTGTGRGGTSIYGDKFDDEIHSDL
HHTGAGILSMANAGPNTNSSQFFITLAPTPWLDGKHTIFG
RVVSGLSVCKRMGLIRTDSSDRPIEPLKIIKAVAL
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| e: |
RLRTSRTKRPPDGFDEIEPTLIEFQDRMRQIENTMGKGTK
TEMLAPIFQLHHQRSRYIYDLYYKREAISTELYNWLLKQN
YADGNLIAKWKKPGYEKLCCLRCIQTAESKFGSTCICRVP
KSKLDKDQRVRCTHCGCNGCASCD
|
| f: |
MKLVRFLMKLTNETVSIELKNGTIVHGTITSVDMQMNTHL
KAVKMTVKGREPVPVETLSIRGNNIRYYILPDSLPLDTLL
ID
|
| g: |
ENSQSPNIQPLLHTENLAPAVVDNVKDDLIVSKGGNSREL
ARNVPVNEMVQPALGPANPFVTKEQDSIKNSITGYAEREY
VPNFVFNQEYYANTHAIYGKRNFDDNEATTSTDLKRKSQK
IKERREDPGDPSILEGDGAYKGPWAGYG
|
| h: |
TSSRALPAHLKLKYRQESQGTEEEVRKQDLREALLRAEAA
HFATQEHRRWDEDVVFRNTHKGVDDTPRPGFVNDMLRSEF
HKKFLARFVD
|
| i: |
LDSLPYFESTYNEEDRSAAAQIVEEELKRSGSDRLENAIV
AAGKGEKLAAIDVQRYIQLKPPGTRESLLQSAVVWEYQKS
RNDNLYLLEKHGEKAFDSSLEALEVQLELLEKELVNTKKL
SQGCNRKRKHYQMEVGARLAEAEVKFGQLLQSSIQCRVAT
L
|
| j: |
MRLNAEFLSQVPSFISPLKETELDLRQIPIIENLGVLRDV
HDAIDFTDNDIRYLGNFPRMKRLQTLLCGNNRITAIAPDI
GKVLPNLKTLSLAQNHLQEIADLDPLASCPQLTNLSCIDN
PVAQKQYYRLYLIWRIPSLHILDFERVRRNERLRAEEVFG
|
| k: |
TLYVNNLNDKINKNDLRTALYMLFSTYGTVVDIVALKTPK
MRGQAHVVFFDPSAAAIAMKALKNFIFFGKEMKIQYAHSK
SKIIERIVA
|
| l: |
RLEEYEFSAGPLSVLQQAVKNHDQVLINCRNNKKLLARVK
AFDRHSNMVLENVKEMWTEKAINKDRFISKMFLRGDGVVL
VVRIPSA
|
| m: |
MIPPINFIFKLLQQHTPVSIWLFEQTDIRLQGQIRGFDEF
MNIVLDDAVQVDAKNNKRELGRILLKGDNITLIQAI
|
| n: |
VPVNPKPFLQGLIGKPVLVRLKWGQEYKGTLQSVDSYMNL
QLLNAEELVDGVKTGDLGEILIRCNNVLWVGEV
|
| o: |
KAGAPDLKKYLDRQVFVQLNGSRKVYGVLRGYDIFLNIVL
EDSIEEKVDGEKVKIGSVAIRGNSVIMIETLDK
|
| r: |
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXTTRK
LYDRVFELTPQVVVNYANLLEENAYFEDSFKIYERGVALF
SYPVAFELWNLYLTKFVKRYQGTHMERTRDLFEQALEKSI
YLLYADFEEKFGKAKRSISILEKAALAIYNVLLVKVALNY
GVLATRTVYEKAIEXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXX
|
| x: |
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
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Description
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