eF-site/Summary 3jaf-C

eF-site ID	3jaf-C
PDB Code	3jaf
Chain	C

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Title	Structure of alpha-1 glycine receptor by single particle electron cryo-microscopy, glycine/ivermectin-bound state
Classification	SIGNALING PROTEIN
Compound	Glycine receptor subunit alphaZ1
Source	(3JAF)

Sequence	C:	APSEFLDKLMGKVSGYDARIRPNFKGPPVNVTCNIFINSF GSIAETTMDYRVNIFLRQQWNDPRLAYSEYPDDSLDLDPS MLDSIWKPDLFFANEKGANFHEVTTDNKLLRISKNGNVLY SIRITLVLACPMDLKNFPMDVQTCIMQLESFGYTMNDLIF EWDEKGAVQVADGLTLPQFILKEEKDLRYCTKHYNTGKFT CIEARFHLERQMGYYLIQMYIPSLLIVILSWVSFWINMDA APARVGLGITTVLTMTTQSSGSRASLPKVSYVKAIDIWMA VCLLFVFSALLEYAAVNFIARAGTKLFISRAKRIDTVSRV AFPLVFLIFNIFYWITYKLVPR

Description	(1)	zebra fish alpha1 glycine receptor

Functional site


1)	chain	C
	residue	54
	type	CARBOHYD
	sequence	N
	description	N-linked (GlcNAc...) asparagine => ECO:0000255, ECO:0000269\|PubMed:26344198
	source	Swiss-Prot : SWS_FT_FI10

2)	chain	C
	residue	239-260
	type	TRANSMEM
	sequence	YLIQMYIPSLLIVILSWVSFWI
	description	Helical; Name=1 => ECO:0000269\|PubMed:26344198
	source	Swiss-Prot : SWS_FT_FI1

3)	chain	C
	residue	261-265
	type	TOPO_DOM
	sequence	NMDAA
	description	Cytoplasmic => ECO:0000269\|PubMed:26344198
	source	Swiss-Prot : SWS_FT_FI2

4)	chain	C
	residue	266-286
	type	TRANSMEM
	sequence	PARVGLGITTVLTMTTQSSGS
	description	Helical; Name=2 => ECO:0000269\|PubMed:26344198
	source	Swiss-Prot : SWS_FT_FI3

5)	chain	C
	residue	287-297
	type	TOPO_DOM
	sequence	RASLPKVSYVK
	description	Extracellular => ECO:0000269\|PubMed:26344198
	source	Swiss-Prot : SWS_FT_FI4

6)	chain	C
	residue	298-318
	type	TRANSMEM
	sequence	AIDIWMAVCLLFVFSALLEYA
	description	Helical; Name=3 => ECO:0000269\|PubMed:26344198
	source	Swiss-Prot : SWS_FT_FI5

7)	chain	C
	residue	208
	type	BINDING
	sequence	E
	description	BINDING => ECO:0000250\|UniProtKB:P23415
	source	Swiss-Prot : SWS_FT_FI7

8)	chain	C
	residue	210
	type	BINDING
	sequence	D
	description	BINDING => ECO:0000250\|UniProtKB:P23415
	source	Swiss-Prot : SWS_FT_FI7

9)	chain	C
	residue	231
	type	BINDING
	sequence	H
	description	BINDING => ECO:0000250\|UniProtKB:P23415
	source	Swiss-Prot : SWS_FT_FI7

10)	chain	C
	residue	218
	type	BINDING
	sequence	Y
	description	BINDING => ECO:0000269\|PubMed:26344198
	source	Swiss-Prot : SWS_FT_FI8

11)	chain	C
	residue	277
	type	SITE
	sequence	L
	description	Important for obstruction of the ion pore in the closed conformation => ECO:0000269\|PubMed:26344198
	source	Swiss-Prot : SWS_FT_FI9