eF-site ID 3jaf-A PDB Code 3jaf Chain A click to enlarge Title Structure of alpha-1 glycine receptor by single particle electron cryo-microscopy, glycine/ivermectin-bound state Classification SIGNALING PROTEIN Compound Glycine receptor subunit alphaZ1 Source (3JAF) Sequence A:  APSEFLDKLMGKVSGYDARIRPNFKGPPVNVTCNIFINSF GSIAETTMDYRVNIFLRQQWNDPRLAYSEYPDDSLDLDPS MLDSIWKPDLFFANEKGANFHEVTTDNKLLRISKNGNVLY SIRITLVLACPMDLKNFPMDVQTCIMQLESFGYTMNDLIF EWDEKGAVQVADGLTLPQFILKEEKDLRYCTKHYNTGKFT CIEARFHLERQMGYYLIQMYIPSLLIVILSWVSFWINMDA APARVGLGITTVLTMTTQSSGSRASLPKVSYVKAIDIWMA VCLLFVFSALLEYAAVNFIARAGTKLFISRAKRIDTVSRV AFPLVFLIFNIFYWITYKLVPR Description (1)  zebra fish alpha1 glycine receptor Functional site 1) chain A residue 54 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000255, ECO:0000269|PubMed:26344198 source Swiss-Prot : SWS_FT_FI10 2) chain A residue 154-168 type prosite sequence CPMDLKNFPMDVQTC description NEUROTR_ION_CHANNEL Neurotransmitter-gated ion-channels signature. CpMdLknFPmDvqtC source prosite : PS00236 3) chain A residue 239-260 type TRANSMEM sequence YLIQMYIPSLLIVILSWVSFWI description Helical; Name=1 => ECO:0000269|PubMed:26344198 source Swiss-Prot : SWS_FT_FI1 4) chain A residue 261-265 type TOPO_DOM sequence NMDAA description Cytoplasmic => ECO:0000269|PubMed:26344198 source Swiss-Prot : SWS_FT_FI2 5) chain A residue 266-286 type TRANSMEM sequence PARVGLGITTVLTMTTQSSGS description Helical; Name=2 => ECO:0000269|PubMed:26344198 source Swiss-Prot : SWS_FT_FI3 6) chain A residue 287-297 type TOPO_DOM sequence RASLPKVSYVK description Extracellular => ECO:0000269|PubMed:26344198 source Swiss-Prot : SWS_FT_FI4 7) chain A residue 298-318 type TRANSMEM sequence AIDIWMAVCLLFVFSALLEYA description Helical; Name=3 => ECO:0000269|PubMed:26344198 source Swiss-Prot : SWS_FT_FI5 8) chain A residue 208 type BINDING sequence E description BINDING => ECO:0000250|UniProtKB:P23415 source Swiss-Prot : SWS_FT_FI7 9) chain A residue 210 type BINDING sequence D description BINDING => ECO:0000250|UniProtKB:P23415 source Swiss-Prot : SWS_FT_FI7 10) chain A residue 231 type BINDING sequence H description BINDING => ECO:0000250|UniProtKB:P23415 source Swiss-Prot : SWS_FT_FI7 11) chain A residue 218 type BINDING sequence Y description BINDING => ECO:0000269|PubMed:26344198 source Swiss-Prot : SWS_FT_FI8 12) chain A residue 277 type SITE sequence L description Important for obstruction of the ion pore in the closed conformation => ECO:0000269|PubMed:26344198 source Swiss-Prot : SWS_FT_FI9

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