eF-site ID 3j9p-D PDB Code 3j9p Chain D click to enlarge Title Structure of the TRPA1 ion channel determined by electron cryo-microscopy Classification TRANSPORT PROTEIN Compound Maltose-binding periplasmic protein, Transient receptor potential cation channel subfamily A member 1 chimera Source (TRPA1_HUMAN) Sequence D:  KKSPLHFAASYGRINTCQRLLQDISDTRLLNEGDLHGMTP LHLAAKNGHDKVVQLLLKKGALFLSDHNGWTALHHASMGG YTQTMKVILDTNLKCTDRLDEDGNTALHFAAREGHAKAVA LLLSHNADIVLNKQQASFLHLALHNKRKEVVLTIIRSKRW DECLKIFSHNSPGNKCPITEMIEYLPECMKVLLDFCMLHS TEDKSCRDYYIEYNFKYLYEPLTALNAMVQNNRIELLNHP VCKEYLLMKWLAYGFRAHMMNLGSYCLGLIPMTILVVNIK PGMAFNTTNSYLIKTCMILVFLSSIFGYISNVLEWIIYTT GIIFVLPLFVEIPAHLQWQCGAIAVYFYWMNFLLYLQRFE NCGIFIVMLEVILKTLLRSTVVFIFLLLAFGLSFYILLNL QDPFSSPLLSIIQTFSMMLGDINYRESFLEPYLRNELAHP VLSFAQLVSFTIFVPIVLMNLLIGLAVGDIADVQKHASLK RIAMQVELHTSLEKKLPLWFLRKVDQKSTIVYQEIPNADK SLEMEILKQKYRLKDLTFLLEKQHELIKLIIQKMEIISET Description Functional site 1) chain D residue 747 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000255 source Swiss-Prot : SWS_FT_FI20 2) chain D residue 621 type BINDING sequence C description covalent; Cys highly reactive => ECO:0000250|UniProtKB:Q8BLA8, ECO:0000305|PubMed:17164327, ECO:0000305|PubMed:27241698 source Swiss-Prot : SWS_FT_FI11 3) chain D residue 1046 type BINDING sequence K description BINDING => ECO:0000305|PubMed:25855297 source Swiss-Prot : SWS_FT_FI14 4) chain D residue 620 type SITE sequence K description Required for C-621 reactivity => ECO:0000269|PubMed:27241698 source Swiss-Prot : SWS_FT_FI15 5) chain D residue 622 type SITE sequence P description Key residue for activation by the scorpion wasabi receptor toxin => ECO:0000269|PubMed:31447178 source Swiss-Prot : SWS_FT_FI16 6) chain D residue 634 type SITE sequence M description Important residue for activation by the scorpion wasabi receptor toxin => ECO:0000269|PubMed:31447178 source Swiss-Prot : SWS_FT_FI17 7) chain D residue 646 type SITE sequence T description Important residue for activation by the scorpion wasabi receptor toxin => ECO:0000269|PubMed:31447178 source Swiss-Prot : SWS_FT_FI17 8) chain D residue 633 type MOD_RES sequence C description Cysteine sulfenic acid (-SOH); transient; in hyperoxia => ECO:0000305|PubMed:21873995 source Swiss-Prot : SWS_FT_FI19 9) chain D residue 856 type MOD_RES sequence C description Cysteine sulfenic acid (-SOH); transient; in hyperoxia => ECO:0000305|PubMed:21873995 source Swiss-Prot : SWS_FT_FI19 10) chain D residue 720-740 type TRANSMEM sequence MMNLGSYCLGLIPMTILVVNI description Helical; Name=1 => ECO:0000305|PubMed:25855297 source Swiss-Prot : SWS_FT_FI1 11) chain D residue 741-764 type TOPO_DOM sequence KPGMAFNT description Extracellular => ECO:0000305|PubMed:25855297 source Swiss-Prot : SWS_FT_FI2 12) chain D residue 825-829 type TOPO_DOM sequence EIPAH description Extracellular => ECO:0000305|PubMed:25855297 source Swiss-Prot : SWS_FT_FI2 13) chain D residue 895-901 type TOPO_DOM sequence QDPFSSP description Extracellular => ECO:0000305|PubMed:25855297 source Swiss-Prot : SWS_FT_FI2 14) chain D residue 923-934 type TOPO_DOM sequence LEPYLRNELAHP description Extracellular => ECO:0000305|PubMed:25855297 source Swiss-Prot : SWS_FT_FI2 15) chain D residue 765-785 type TRANSMEM sequence TNSYLIKTCMILVFLSSIFGY description Helical; Name=2 => ECO:0000305|PubMed:25855297 source Swiss-Prot : SWS_FT_FI3 16) chain D residue 851-873 type TOPO_DOM sequence QRFENCGIFIVMLEVILKTLLRS description Cytoplasmic => ECO:0000305|PubMed:25855297 source Swiss-Prot : SWS_FT_FI4 17) chain D residue 804-824 type TRANSMEM sequence SNVLEWIIYTTGIIFVLPLFV description Helical; Name=3 => ECO:0000305|PubMed:25855297 source Swiss-Prot : SWS_FT_FI5 18) chain D residue 830-850 type TRANSMEM sequence LQWQCGAIAVYFYWMNFLLYL description Helical; Name=4 => ECO:0000305|PubMed:25855297 source Swiss-Prot : SWS_FT_FI6 19) chain D residue 874-894 type TRANSMEM sequence TVVFIFLLLAFGLSFYILLNL description Helical; Name=5 => ECO:0000305|PubMed:25855297 source Swiss-Prot : SWS_FT_FI7 20) chain D residue 902-922 type INTRAMEM sequence LLSIIQTFSMMLGDINYRESF description Pore-forming => ECO:0000305|PubMed:25855297 source Swiss-Prot : SWS_FT_FI8 21) chain D residue 935-956 type TRANSMEM sequence VLSFAQLVSFTIFVPIVLMNLL description Helical; Name=6 => ECO:0000305|PubMed:25855297 source Swiss-Prot : SWS_FT_FI9 22) chain D residue 641 type BINDING sequence C description covalent => ECO:0000305|PubMed:17164327 source Swiss-Prot : SWS_FT_FI12 23) chain D residue 710 type BINDING sequence K description covalent => ECO:0000305|PubMed:17164327 source Swiss-Prot : SWS_FT_FI12 24) chain D residue 468-480 type prosite sequence DISDTRLLNEGDL description EF_HAND_1 EF-hand calcium-binding domain. DISDTRLLNegDL source prosite : PS00018

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