eF-site ID 3j9p-C
PDB Code 3j9p
Chain C

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Title Structure of the TRPA1 ion channel determined by electron cryo-microscopy
Classification TRANSPORT PROTEIN
Compound Maltose-binding periplasmic protein, Transient receptor potential cation channel subfamily A member 1 chimera
Source (TRPA1_HUMAN)
Sequence C:  KKSPLHFAASYGRINTCQRLLQDISDTRLLNEGDLHGMTP
LHLAAKNGHDKVVQLLLKKGALFLSDHNGWTALHHASMGG
YTQTMKVILDTNLKCTDRLDEDGNTALHFAAREGHAKAVA
LLLSHNADIVLNKQQASFLHLALHNKRKEVVLTIIRSKRW
DECLKIFSHNSPGNKCPITEMIEYLPECMKVLLDFCMLHS
TEDKSCRDYYIEYNFKYLYEPLTALNAMVQNNRIELLNHP
VCKEYLLMKWLAYGFRAHMMNLGSYCLGLIPMTILVVNIK
PGMAFNTTNSYLIKTCMILVFLSSIFGYISNVLEWIIYTT
GIIFVLPLFVEIPAHLQWQCGAIAVYFYWMNFLLYLQRFE
NCGIFIVMLEVILKTLLRSTVVFIFLLLAFGLSFYILLNL
QDPFSSPLLSIIQTFSMMLGDINYRESFLEPYLRNELAHP
VLSFAQLVSFTIFVPIVLMNLLIGLAVGDIADVQKHASLK
RIAMQVELHTSLEKKLPLWFLRKVDQKSTIVYQEIPNADK
SLEMEILKQKYRLKDLTFLLEKQHELIKLIIQKMEIISET
Description


Functional site

1) chain C
residue 719-739
type TRANSMEM
sequence HMMNLGSYCLGLIPMTILVVN
description Helical; Name=1 => ECO:0000269|PubMed:31866091, ECO:0007744|PDB:6PQO
source Swiss-Prot : SWS_FT_FI1

2) chain C
residue 621
type BINDING
sequence C
description covalent; Cys highly reactive => ECO:0000250|UniProtKB:Q8BLA8, ECO:0000305|PubMed:17164327, ECO:0000305|PubMed:27241698
source Swiss-Prot : SWS_FT_FI11

3) chain C
residue 641
type BINDING
sequence C
description covalent => ECO:0000305|PubMed:17164327
source Swiss-Prot : SWS_FT_FI12

4) chain C
residue 710
type BINDING
sequence K
description covalent => ECO:0000305|PubMed:17164327
source Swiss-Prot : SWS_FT_FI12

5) chain C
residue 805
type BINDING
sequence N
description BINDING => ECO:0000269|PubMed:32641835, ECO:0007744|PDB:6V9V
source Swiss-Prot : SWS_FT_FI14

6) chain C
residue 808
type BINDING
sequence E
description BINDING => ECO:0000269|PubMed:32641835, ECO:0007744|PDB:6V9V
source Swiss-Prot : SWS_FT_FI14

7) chain C
residue 1046
type BINDING
sequence K
description BINDING => ECO:0000305|PubMed:25855297
source Swiss-Prot : SWS_FT_FI15

8) chain C
residue 620
type SITE
sequence K
description Required for C-621 reactivity => ECO:0000269|PubMed:27241698
source Swiss-Prot : SWS_FT_FI16

9) chain C
residue 621
type SITE
sequence C
description Essential for electrophile activation. Sensor for electrophilic agents => ECO:0000269|PubMed:31866091, ECO:0000269|PubMed:32641835
source Swiss-Prot : SWS_FT_FI17

10) chain C
residue 622
type SITE
sequence P
description Key residue for activation by the scorpion wasabi receptor toxin => ECO:0000269|PubMed:31447178
source Swiss-Prot : SWS_FT_FI18

11) chain C
residue 634
type SITE
sequence M
description Important residue for activation by the scorpion wasabi receptor toxin => ECO:0000269|PubMed:31447178
source Swiss-Prot : SWS_FT_FI19

12) chain C
residue 646
type SITE
sequence T
description Important residue for activation by the scorpion wasabi receptor toxin => ECO:0000269|PubMed:31447178
source Swiss-Prot : SWS_FT_FI19

13) chain C
residue 740-767
type TOPO_DOM
sequence IKPGMAFNTTNS
description Extracellular => ECO:0000305
source Swiss-Prot : SWS_FT_FI2

14) chain C
residue 824-829
type TOPO_DOM
sequence VEIPAH
description Extracellular => ECO:0000305
source Swiss-Prot : SWS_FT_FI2

15) chain C
residue 893-901
type TOPO_DOM
sequence NLQDPFSSP
description Extracellular => ECO:0000305
source Swiss-Prot : SWS_FT_FI2

16) chain C
residue 923-933
type TOPO_DOM
sequence LEPYLRNELAH
description Extracellular => ECO:0000305
source Swiss-Prot : SWS_FT_FI2

17) chain C
residue 915
type SITE
sequence D
description Crucial for calcium permeation => ECO:0000250|UniProtKB:Q6RI86
source Swiss-Prot : SWS_FT_FI21

18) chain C
residue 633
type MOD_RES
sequence C
description Cysteine sulfenic acid (-SOH); transient; in hyperoxia => ECO:0000305|PubMed:21873995
source Swiss-Prot : SWS_FT_FI23

19) chain C
residue 856
type MOD_RES
sequence C
description Cysteine sulfenic acid (-SOH); transient; in hyperoxia => ECO:0000305|PubMed:21873995
source Swiss-Prot : SWS_FT_FI23

20) chain C
residue 747
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine => ECO:0000255
source Swiss-Prot : SWS_FT_FI24

21) chain C
residue 851-862
type TOPO_DOM
sequence QRFENCGIFIVM
description Cytoplasmic => ECO:0000305
source Swiss-Prot : SWS_FT_FI4

22) chain C
residue 830-850
type TRANSMEM
sequence LQWQCGAIAVYFYWMNFLLYL
description Helical; Name=4 => ECO:0000269|PubMed:31866091, ECO:0007744|PDB:6PQO
source Swiss-Prot : SWS_FT_FI6

23) chain C
residue 863-892
type TRANSMEM
sequence LEVILKTLLRSTVVFIFLLLAFGLSFYILL
description Helical; Name=5 => ECO:0000269|PubMed:31866091, ECO:0007744|PDB:6PQO
source Swiss-Prot : SWS_FT_FI7

24) chain C
residue 902-922
type INTRAMEM
sequence LLSIIQTFSMMLGDINYRESF
description Pore-forming => ECO:0000269|PubMed:31866091, ECO:0007744|PDB:6PQO
source Swiss-Prot : SWS_FT_FI8

25) chain C
residue 934-960
type TRANSMEM
sequence PVLSFAQLVSFTIFVPIVLMNLLIGLA
description Helical; Name=6 => ECO:0000269|PubMed:31866091, ECO:0007744|PDB:6PQO
source Swiss-Prot : SWS_FT_FI9


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