eF-site ID 3j9p-C PDB Code 3j9p Chain C click to enlarge Title Structure of the TRPA1 ion channel determined by electron cryo-microscopy Classification TRANSPORT PROTEIN Compound Maltose-binding periplasmic protein, Transient receptor potential cation channel subfamily A member 1 chimera Source (TRPA1_HUMAN) Sequence C:  KKSPLHFAASYGRINTCQRLLQDISDTRLLNEGDLHGMTP LHLAAKNGHDKVVQLLLKKGALFLSDHNGWTALHHASMGG YTQTMKVILDTNLKCTDRLDEDGNTALHFAAREGHAKAVA LLLSHNADIVLNKQQASFLHLALHNKRKEVVLTIIRSKRW DECLKIFSHNSPGNKCPITEMIEYLPECMKVLLDFCMLHS TEDKSCRDYYIEYNFKYLYEPLTALNAMVQNNRIELLNHP VCKEYLLMKWLAYGFRAHMMNLGSYCLGLIPMTILVVNIK PGMAFNTTNSYLIKTCMILVFLSSIFGYISNVLEWIIYTT GIIFVLPLFVEIPAHLQWQCGAIAVYFYWMNFLLYLQRFE NCGIFIVMLEVILKTLLRSTVVFIFLLLAFGLSFYILLNL QDPFSSPLLSIIQTFSMMLGDINYRESFLEPYLRNELAHP VLSFAQLVSFTIFVPIVLMNLLIGLAVGDIADVQKHASLK RIAMQVELHTSLEKKLPLWFLRKVDQKSTIVYQEIPNADK SLEMEILKQKYRLKDLTFLLEKQHELIKLIIQKMEIISET Description Functional site 1) chain C residue 719-739 type TRANSMEM sequence HMMNLGSYCLGLIPMTILVVN description Helical; Name=1 => ECO:0000269|PubMed:31866091, ECO:0007744|PDB:6PQO source Swiss-Prot : SWS_FT_FI1 2) chain C residue 621 type BINDING sequence C description covalent; Cys highly reactive => ECO:0000250|UniProtKB:Q8BLA8, ECO:0000305|PubMed:17164327, ECO:0000305|PubMed:27241698 source Swiss-Prot : SWS_FT_FI11 3) chain C residue 641 type BINDING sequence C description covalent => ECO:0000305|PubMed:17164327 source Swiss-Prot : SWS_FT_FI12 4) chain C residue 710 type BINDING sequence K description covalent => ECO:0000305|PubMed:17164327 source Swiss-Prot : SWS_FT_FI12 5) chain C residue 805 type BINDING sequence N description BINDING => ECO:0000269|PubMed:32641835, ECO:0007744|PDB:6V9V source Swiss-Prot : SWS_FT_FI14 6) chain C residue 808 type BINDING sequence E description BINDING => ECO:0000269|PubMed:32641835, ECO:0007744|PDB:6V9V source Swiss-Prot : SWS_FT_FI14 7) chain C residue 1046 type BINDING sequence K description BINDING => ECO:0000305|PubMed:25855297 source Swiss-Prot : SWS_FT_FI15 8) chain C residue 620 type SITE sequence K description Required for C-621 reactivity => ECO:0000269|PubMed:27241698 source Swiss-Prot : SWS_FT_FI16 9) chain C residue 621 type SITE sequence C description Essential for electrophile activation. Sensor for electrophilic agents => ECO:0000269|PubMed:31866091, ECO:0000269|PubMed:32641835 source Swiss-Prot : SWS_FT_FI17 10) chain C residue 622 type SITE sequence P description Key residue for activation by the scorpion wasabi receptor toxin => ECO:0000269|PubMed:31447178 source Swiss-Prot : SWS_FT_FI18 11) chain C residue 634 type SITE sequence M description Important residue for activation by the scorpion wasabi receptor toxin => ECO:0000269|PubMed:31447178 source Swiss-Prot : SWS_FT_FI19 12) chain C residue 646 type SITE sequence T description Important residue for activation by the scorpion wasabi receptor toxin => ECO:0000269|PubMed:31447178 source Swiss-Prot : SWS_FT_FI19 13) chain C residue 740-767 type TOPO_DOM sequence IKPGMAFNTTNS description Extracellular => ECO:0000305 source Swiss-Prot : SWS_FT_FI2 14) chain C residue 824-829 type TOPO_DOM sequence VEIPAH description Extracellular => ECO:0000305 source Swiss-Prot : SWS_FT_FI2 15) chain C residue 893-901 type TOPO_DOM sequence NLQDPFSSP description Extracellular => ECO:0000305 source Swiss-Prot : SWS_FT_FI2 16) chain C residue 923-933 type TOPO_DOM sequence LEPYLRNELAH description Extracellular => ECO:0000305 source Swiss-Prot : SWS_FT_FI2 17) chain C residue 915 type SITE sequence D description Crucial for calcium permeation => ECO:0000250|UniProtKB:Q6RI86 source Swiss-Prot : SWS_FT_FI21 18) chain C residue 633 type MOD_RES sequence C description Cysteine sulfenic acid (-SOH); transient; in hyperoxia => ECO:0000305|PubMed:21873995 source Swiss-Prot : SWS_FT_FI23 19) chain C residue 856 type MOD_RES sequence C description Cysteine sulfenic acid (-SOH); transient; in hyperoxia => ECO:0000305|PubMed:21873995 source Swiss-Prot : SWS_FT_FI23 20) chain C residue 747 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000255 source Swiss-Prot : SWS_FT_FI24 21) chain C residue 851-862 type TOPO_DOM sequence QRFENCGIFIVM description Cytoplasmic => ECO:0000305 source Swiss-Prot : SWS_FT_FI4 22) chain C residue 830-850 type TRANSMEM sequence LQWQCGAIAVYFYWMNFLLYL description Helical; Name=4 => ECO:0000269|PubMed:31866091, ECO:0007744|PDB:6PQO source Swiss-Prot : SWS_FT_FI6 23) chain C residue 863-892 type TRANSMEM sequence LEVILKTLLRSTVVFIFLLLAFGLSFYILL description Helical; Name=5 => ECO:0000269|PubMed:31866091, ECO:0007744|PDB:6PQO source Swiss-Prot : SWS_FT_FI7 24) chain C residue 902-922 type INTRAMEM sequence LLSIIQTFSMMLGDINYRESF description Pore-forming => ECO:0000269|PubMed:31866091, ECO:0007744|PDB:6PQO source Swiss-Prot : SWS_FT_FI8 25) chain C residue 934-960 type TRANSMEM sequence PVLSFAQLVSFTIFVPIVLMNLLIGLA description Helical; Name=6 => ECO:0000269|PubMed:31866091, ECO:0007744|PDB:6PQO source Swiss-Prot : SWS_FT_FI9

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