eF-site ID 3j9p-A PDB Code 3j9p Chain A click to enlarge Title Structure of the TRPA1 ion channel determined by electron cryo-microscopy Classification TRANSPORT PROTEIN Compound Maltose-binding periplasmic protein, Transient receptor potential cation channel subfamily A member 1 chimera Source (TRPA1_HUMAN) Sequence A:  KKSPLHFAASYGRINTCQRLLQDISDTRLLNEGDLHGMTP LHLAAKNGHDKVVQLLLKKGALFLSDHNGWTALHHASMGG YTQTMKVILDTNLKCTDRLDEDGNTALHFAAREGHAKAVA LLLSHNADIVLNKQQASFLHLALHNKRKEVVLTIIRSKRW DECLKIFSHNSPGNKCPITEMIEYLPECMKVLLDFCMLHS TEDKSCRDYYIEYNFKYLYEPLTALNAMVQNNRIELLNHP VCKEYLLMKWLAYGFRAHMMNLGSYCLGLIPMTILVVNIK PGMAFNTTNSYLIKTCMILVFLSSIFGYISNVLEWIIYTT GIIFVLPLFVEIPAHLQWQCGAIAVYFYWMNFLLYLQRFE NCGIFIVMLEVILKTLLRSTVVFIFLLLAFGLSFYILLNL QDPFSSPLLSIIQTFSMMLGDINYRESFLEPYLRNELAHP VLSFAQLVSFTIFVPIVLMNLLIGLAVGDIADVQKHASLK RIAMQVELHTSLEKKLPLWFLRKVDQKSTIVYQEIPNADK SLEMEILKQKYRLKDLTFLLEKQHELIKLIIQKMEIISET Description Functional site 1) chain A residue 747 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000255 source Swiss-Prot : SWS_FT_FI20 2) chain A residue 621 type BINDING sequence C description covalent; Cys highly reactive => ECO:0000250|UniProtKB:Q8BLA8, ECO:0000305|PubMed:17164327, ECO:0000305|PubMed:27241698 source Swiss-Prot : SWS_FT_FI11 3) chain A residue 1046 type BINDING sequence K description BINDING => ECO:0000305|PubMed:25855297 source Swiss-Prot : SWS_FT_FI14 4) chain A residue 620 type SITE sequence K description Required for C-621 reactivity => ECO:0000269|PubMed:27241698 source Swiss-Prot : SWS_FT_FI15 5) chain A residue 622 type SITE sequence P description Key residue for activation by the scorpion wasabi receptor toxin => ECO:0000269|PubMed:31447178 source Swiss-Prot : SWS_FT_FI16 6) chain A residue 634 type SITE sequence M description Important residue for activation by the scorpion wasabi receptor toxin => ECO:0000269|PubMed:31447178 source Swiss-Prot : SWS_FT_FI17 7) chain A residue 646 type SITE sequence T description Important residue for activation by the scorpion wasabi receptor toxin => ECO:0000269|PubMed:31447178 source Swiss-Prot : SWS_FT_FI17 8) chain A residue 633 type MOD_RES sequence C description Cysteine sulfenic acid (-SOH); transient; in hyperoxia => ECO:0000305|PubMed:21873995 source Swiss-Prot : SWS_FT_FI19 9) chain A residue 856 type MOD_RES sequence C description Cysteine sulfenic acid (-SOH); transient; in hyperoxia => ECO:0000305|PubMed:21873995 source Swiss-Prot : SWS_FT_FI19 10) chain A residue 720-740 type TRANSMEM sequence MMNLGSYCLGLIPMTILVVNI description Helical; Name=1 => ECO:0000305|PubMed:25855297 source Swiss-Prot : SWS_FT_FI1 11) chain A residue 741-764 type TOPO_DOM sequence KPGMAFNT description Extracellular => ECO:0000305|PubMed:25855297 source Swiss-Prot : SWS_FT_FI2 12) chain A residue 825-829 type TOPO_DOM sequence EIPAH description Extracellular => ECO:0000305|PubMed:25855297 source Swiss-Prot : SWS_FT_FI2 13) chain A residue 895-901 type TOPO_DOM sequence QDPFSSP description Extracellular => ECO:0000305|PubMed:25855297 source Swiss-Prot : SWS_FT_FI2 14) chain A residue 923-934 type TOPO_DOM sequence LEPYLRNELAHP description Extracellular => ECO:0000305|PubMed:25855297 source Swiss-Prot : SWS_FT_FI2 15) chain A residue 765-785 type TRANSMEM sequence TNSYLIKTCMILVFLSSIFGY description Helical; Name=2 => ECO:0000305|PubMed:25855297 source Swiss-Prot : SWS_FT_FI3 16) chain A residue 851-873 type TOPO_DOM sequence QRFENCGIFIVMLEVILKTLLRS description Cytoplasmic => ECO:0000305|PubMed:25855297 source Swiss-Prot : SWS_FT_FI4 17) chain A residue 804-824 type TRANSMEM sequence SNVLEWIIYTTGIIFVLPLFV description Helical; Name=3 => ECO:0000305|PubMed:25855297 source Swiss-Prot : SWS_FT_FI5 18) chain A residue 830-850 type TRANSMEM sequence LQWQCGAIAVYFYWMNFLLYL description Helical; Name=4 => ECO:0000305|PubMed:25855297 source Swiss-Prot : SWS_FT_FI6 19) chain A residue 874-894 type TRANSMEM sequence TVVFIFLLLAFGLSFYILLNL description Helical; Name=5 => ECO:0000305|PubMed:25855297 source Swiss-Prot : SWS_FT_FI7 20) chain A residue 902-922 type INTRAMEM sequence LLSIIQTFSMMLGDINYRESF description Pore-forming => ECO:0000305|PubMed:25855297 source Swiss-Prot : SWS_FT_FI8 21) chain A residue 935-956 type TRANSMEM sequence VLSFAQLVSFTIFVPIVLMNLL description Helical; Name=6 => ECO:0000305|PubMed:25855297 source Swiss-Prot : SWS_FT_FI9 22) chain A residue 641 type BINDING sequence C description covalent => ECO:0000305|PubMed:17164327 source Swiss-Prot : SWS_FT_FI12 23) chain A residue 710 type BINDING sequence K description covalent => ECO:0000305|PubMed:17164327 source Swiss-Prot : SWS_FT_FI12

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