eF-site ID 3j79-0123456789DEFGHIJKLMNOPQRSTUVWXYZabcdefghi PDB Code 3j79 Chain 0, 1, 2, 3, 4, 5, 6, 7, 8, 9, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X, Y, Z, a, b, c, d, e, f, g, h, i Title Cryo-EM structure of the Plasmodium falciparum 80S ribosome bound to the anti-protozoan drug emetine, large subunit Classification RIBOSOME/INHIBITOR Compound 28S ribosomal RNA Source ORGANISM_SCIENTIFIC: Plasmodium falciparum; Sequence 0:  VKTEACSFSEYRIYPGRGQKYIARDGKVYFYLSSKFASLA LQKKKAAKLRWTQTWRRNNKKT 1:  GKLLKPGKVIIILNGRRAGKKAVIVNTYEGQTRERPYSYC LVAGIEKHPLKVNKSMTKKKIVKRSKVKAFIKCINVNHIL PTRYQVANDFDIKSLASDDVLKSKNKKKEVKKLGKIFRDK FLEPVEVSKDISFLHKKLYF 2:  SNVSNALVWELTRKSNCFIKKNKAGKKGVFLCDPLNVNYK NTPSSSGLVKSNSTNVTLKDGKVVFSVKVNQHFKMKNVEK LLQQHGSKNKEKLLKKYKRLSKLY 3:  NVKAYELRTLKKKELLDKLDELKKELSGLRISKALGNSAK NSKIHGVRKNVARVLTVYNQKRKMELRQLYKNKKFKPYNL RKKLTKNKRLQLSPKQKAAMTLRQKKKVQNFPQRKYLVV 4:  AKSKNHTNHNQNRKAHKNGIKKPKKHKFMSRKGLDPNFFR NQKYCLKGIQKKKKELKLKAKQEKNN 5:  AAKKIKTLKLINKKKRNDLRQRTLRYEEEYESERKKIIEL KREARKNNCFYREAEKKVVFVIRLKGVNKLPPKVRSVFRL LRLLQVHNGVFVKVNKATKEMLKIVEPYVTYGYPTLSTVR KLLYKRGYVRVGKVRRYARKKIQDNADISKHLGKYNVHGI EDMVYQLYTCGPVFKKVNNFLWAFKLKPPRKGFKAKRHAF NEPRPGDWGNREAHINELINRMI 6:  SAGDNINAKLQLVMKSGKYQFGRKSCLKALRTGKGKLVIV SSNCPSIQRSVIEYYAMLSKCGVHDYHGDNNDLGTACGKL FRISCLVITDVGDSDIIK 7:  PVTKFITINLSKLTHKVCYKRKAPRAIKEIRSIAGKLMHT KDVRLDVKLNKFIWSKGVRNPPKRVRVKLERKRNEKMYTI VEHVMVDSYKGLVNEC 8:  AVKKVGKIIKKRTKKFTRFQSNRFMRVKPAWRKPRGIDCR VRRRYKGTNLMPSIGYGSNKKTKFLLPNNKYKYVVKNVKE MEPLIMNHTKYCVQIAHNVSSKKRKQIIERAKQMNVSVIN AKARL 9:  LQAVRLYEKGVILGYKRSQRNQDPNFTLISIKNVNTKKHA QFYVGKRVAYVYRTTKHHDGVKIKCIWGKVCRTHGNSGVI RAKFKTHIPPKAFGDRVRILMYP D:  GRVIRGQRKGRGSIFKSHNHHRKGAAKLRHLDYCEKKGYI KGLVKDIIHDPGRGAPLAKVIFKRTEKYGKKEELIIASEG MFTGQYISCGTKAPLSVGNILPIGKMPEGTLICNLEHRTG NRGTLVKASGCYATVVGQSEDGKKTKVRLPSGAKKTIDAK ARAMVGVVGAGGRIDKPILKAGVAHHKYRVKRNCWPKVRG VAMNPVEHPHGGGNHQHIGHPSTVSRSAPAGQKVGLIAAR RTGLLRG E:  SHRKFERPRHGSLGFLPRKRCKRLRGKIRSFPKDDKEKPP HFTAFMGYKAGMTHIVREVDKPGSKLHKKEIVEACTIIEC APMVVVGIVGYRETPKGLRILSTVWANHVSDEFRRRYYKN WYKSEKKAFTKSLNVPEATKNCLLKRIEKYCTVLRAICHT QPSKTPLRMKKAHIMEVQINGGSMKEKLEFVKEMLEKNLP VSTVFNPNEMIDVISVTKGHGTKGVVSRYGVKRLPRKTHR GLRKVACIGAWHPARVQFQIPRHGQKGYFHRTERNKKIYR IGLKTDKNSASTDADITEKKITPMGGFPHYGVVNEDFLLL KGCVAGTKKRPITLRKNIVPQVSRDALAQVSLKFIDTSSK IGHGRFQTSEEKVKYYGPLK F:  PVANVYSTNGKNVVGEVEIPVVFQTPIRNDLIQSVYTNMS KNRRHPYAVKLGAGYETSAESWGTGRAVARIPRVPGGGTH RAGQGAFGNMCRGGGMFNPTKIWRRWGRKVNLKEKRYAVC SSIAASGVTSLVLARGHRISHLKEVPLVVSNDIESLSKTK EAVNFLVSLGLKDEVNRLVKSKKIRAGKGKMRNRKYKIRN GPLIIYENDNGVKKAFRNIPGVDLCKVTKLNLLKLAPGGS IGRLCIWSESAFKKLDVIYGKIHEKKVTKKNYILPKSIVH NPDIYRIIHSDKVQASLLAKKKPCKKRLQNKNSLTNFAVR CRLNPAYKLLRSLAVLRMRKSILEKSKNKKEKRVQKQIQK KELQKINHDYYKGVAKAVKKKKKREEKKAK G:  VMREIKVNKLVLNICVGESGDRLTRAARVLEQLTEQKPIF GKCRKISCFVTVRGKKALEILEKGLKRRKNFSDTGNFGFG IGMDFYVHLSRSGYRVTRRTRRRSKISKTHKVTKEDAMKW FQTK H:  KTIVSTQKVLIPEGVKVAINARKVTVSGKYGTLRRSFRHL PIDIRLNKLKKYIKVVMWFGVPDSLACIRTVCTHLKNMFT GVTKKFLYKMRLVHAHFPINSNIVDNNTRIEIRNYLGEKS VRFVKALPGVVIEKSPNVKDEIYVSGADIENVSLTAALIH QSVLCRNKDIRKFLDGIYVSEVTTV I:  KHYNVKGKKKVLVPVNAKKTINKKYFGRKVASKKKYVVQR KLRKSIEVGKVAIILTGKHMGKRCIITKILNSGLLAVVGP YEINGVPLKRVDSRYLVVTSTNIFNFENIAKLKDDFLNYA QDIDDDSFIKTLEIKKKQKKLLKFMNNVIDKIKEIRKEDP KVQKLEGIQKDIGSLLKPEILKNKVFAHYLKSKFTLRNDM VLHKMKF J:  KDNPLIFEKKKRSNIIGVGVRPKKDLSKYVKWPRYIRIQR KKKILLQRLKVPPSINQFNHTLPKSQTQDLLNFLKAYKPE SKTDKKQRLLNKLFLKYGINHITKLVENKKANLVVIANDV SPIELVLFLPALCRLKEVPYCIVKDKATLGKLVHKKTATA VCLESVKKEDQEKLDYFAKVCKENFNDNVDLRRKWGGQKM SAKSMLLKKMKDKARKIEEAKKKEISAKL K:  MYKKEYVIDCKGHLLGRLASLIAKELLNGQRIVAVRCEDI NISGSLYRNKLKYQEFLRLRTNTNPKKGPLHLREPSKILW RCVRGMLPHKTYKGQLALKKLKVCVGMPYPYDKKKKYVLP SALRAFRLKKHRRYCRLGTLSSRVGWNYDTLVKKNEVLRK QVSKAYYKKKVNNLNEKKEIKTEALNLINPEQRQVLENFG Y L:  VAHNNVLPNVHLHKWWQRHVRVNFSKNIKKKKRRLLREKR RKANGGTPIEKLHPIVHCPTQRYNFRTRLGKGFTFEELKG AGLTPRAAQTIGICYDKRRKNRSEESLTKNVERLLKYKNS LVMIPLKKNKAKKGIGGIPADADKNTIKEFRNKKPLLSIF KKEKNTKPFYETIEVSKIDKEFLAYKTLRRAKLAERRKNR RQQKKDIKFKS M:  TLKNKMRITLSLPVGALINCCDNSGGKNLYIIAVQGFGSC LNRLPAASLGDMVLATVKKGKPDLRKKVLNAIICRQSKAW RRHEGYYIYFEDNAGVIVNPKGEMKGSAITGPVARECAEL WPKLSSAASAIV N:  VELTEEELYISKKNLLFKRFVEPGRLCLIEYGPYAGKLCF IVDIVTITRVIVDGAFITGVPRMVIPLKRLKLLKERIKIN KNCKSGFLRKTVNSTKVLEEFNNSKLGKKMIIKKKRDEAT DFERFQVYFAKRELKKKMTTIKNKKN O:  ATRFKKNRKKRGHVSAGHGRVGKHRKHPGGRGKAGGLHHM RINFDKYHPGYFGKVGMRHLNLLKNRTYCPTINVDKLWGL LPEEKKKEFSENKDIAPVIDVTRKGYFKVLGNGKLKHNQP IVVKARYFSSVAEKKIKAVGGQCILVA P:  GAYKYIQEIWKKKQSDAMHFLLRVRTWEYRQLPVVHRVSK PSRPDKARRLGYKAIQGFVIYRVRVRRGDRKKRVKKGIVH GKPKHQGVHKQKSTRNLKSVAEGKVGKSICGNLRVLNSYW VGQDAVYKYYEVILVDPNHNAVRNNPKINWICNPVHKHRE LRGLTSAGKKYRGLRVKGHLSAKSRPSIRANWKRRQLIKL RKCR Q:  GRRPARCYRYCKNKPYPKSRYCRGVPDPKIRIYDMGRKKA DVNEFSGVVHLVSYEYEQISSEALEAARISANKYMITNCG KDNFHLRVRIHPFHVLRINKAFGKPNGVVARVDIGQVLLS IRTKENFVSKACEALRRAKYKFPGRQKVFVSNKWGFTPFS KDEYQQYKKKGRIISDGVSCKFIREKGPL R:  KVVKNKAYFKRYQVKYRRRREGKTDYRARKALILQDKNKY NAQKLRFVVRKTNSQVICQIACAHIEGDKILAEAKSKELI RYGIPVGLKNYAAAYATGLLCARRFLKSLNLDTQFLGVEK VTRKPIKAFLDVGITRTTTGNRVFAALKGACDGGLNIPHG NNRFPGSFNPEQLRKNILGIHVAEYMKTLQEEDNDKYKTH FNDYLKNNIGADDIEQMYLNAHEKIRQNPKKLNAKLRKKR VKEKLALYVELQ S:  GIALKNVGRIKKHGRKHLVSKNPYLRLLVKLYNFLARRTN ANFNKIIAKRLIMPKRYRPPLSLSKLQYHMANHPNDIAVV VGSITDDKRLFSLKQLKVCALRFTETARKRIEDAGGECLT FDQLALKYPTGKKCVLLRGPTKARTAEKHFGKAPGKPKSK ARPYVRSKGRKFEKARGRRKSRAYKK T:  SLTLQKRLAASVLKCGKNKIWMDPNEISEISLANSRFSIR KLYKEGLILKKPQKVHSRARVRLYKLAKRKGRHMGIGKRK GTKNARTNQKTLWIKRQRVLRRLLKRLRDSKKVDRHLYHS FYLKCKGNQFKNKRTLIEAIQREKNETLKKKAIADQLEAK RLKAQVLRNKRKLKKDKEVVA U:  IDNSLNTNIHQYHIVGRAIPTAKDKNPNVYRMCIFAKNDT NAKSRFWYFMKKINKLKKSNGELLACEQIKERFPLRVKNY GVLLRYDSRTGTHNMYKEFRDTTKEGAIAQLYSEMAGRHR ARASSINIIRISEISSSLVRRPHIKQLLKRRLRFPALHLP TLQKEYRKKFASKRPSTYRM V:  KSRGKRSGTRYKFSKKFRKHGECTANKYLEKLNYGDYVDI VCDSTQQKGMPFNYYHGKTGKIFHITKRGVGVLVNKRVKH RIEQKKVCVRIEHVRKSRCNEDFLLRKIKNAELIKEAKLK NEHINIKRKTEGPKPAAMIKVPPSKIITIEPLPFY W:  YAKKIRNLGKCAKGAGVDLRVHFKNTYEAARAIRRMKLLE AKKYLNDVIEKKRCVPFRKYNGGVGRTNQAKEFNHTQGRW PAKSCKFLLNILDNVQANAESRNLDVSKLRLIHVMVNKAR PGRRRTYKAHGRINPFMSSPCHIQIIAREINISNQNRLKN KSVKKQQTVQ X:  IKYVLDCTKPVKDTILDISGLEQFFKDKIKVDKKTNNLKN KVVVTSDEYKIYITVHIPFSKRYIKYLAKKYIKMHQIRDF LRVIAKGKLAYEFKYFQ Y:  ARNPKCPRIVKSCHSKTLDKYGLIKYPLTSEKAMKKIEEI NTLVFMCDKRANKKNIKKSVKNLFGIECDKVNVLNTLNGD KKAYVRLSGEHDALEVANKIG Z:  KFNKQKSSSRRKMRKAHFTAPAGLRRKIMSSKLSKELRLK YKTRSLPVRKDDEVLICRGHNHGREGKVVKINRKRYKIYV ERVTREKVNGESTFIGIHPSNVVLTKLKVDKNRKKILDRK A a:  AQRVHYRRHNHYNTKSNKVRPVRTPGGKLTIHVVKKKAGK PKCADCKTAIQGVKALRPADNYRARRKNRTVARAYGGSIC ARCIRERIMRAFLFEEQKCVRQVLKE b:  GRKSTIKPATGIAVGFNSGHVVTKRNSKRKELIKDVVREI TGFSPYEKRIIELIKIGTSASTKRSLKYAKKKLGTHKRGK AKREEIQKVVILQRR c:  GKAGKGTGSFGKRNGKTHFLCLRCGKRSYHLQKKKCASCG YPSAKKRRFNWSVKAKRRNTTGTGRCRYIKTLRRKLKNKF TEGSTPKPK d:  PKQITDIRKFLKISRKPDTTAVIIMKKKSKTVITKLKLRT KKYLYTMVFADRKKAERIENSLLPSLKRIYYP e:  GSIKRFRLKQRLGKCRRQNRPVPHWYRLKNTKRRHWRRTK LGL f:  AIEPSLAQLAQKYNCQKLICRKCYARLHPRATNCRNKKCG RTNQLRPKKKL g:  HGASRYKKSRAKMRWKWKKKRTRRLQKKRRKMRQRSR h:  SRRTKKVGLTGKYGTRYGSSLRKQIKKIELMQHAKYLCTF CGKTATKRTCVGIWKCKKCKRKVCGGAWSLTTPAAVAAKS TIIRL i:  VNVPKTRKTYCSNKCKKHTMHKVSQYKKGKERLSSLGRRR YDMKQKGFGGQTKPVFKKKAKTTKKIVLKLECTKCKKKRF QTMKRCKTFEMGADK Description Functional site 1) chain 8 residue 39 type sequence D description BINDING SITE FOR RESIDUE MG A 3806 source : AC6 2) chain D residue 206 type sequence P description BINDING SITE FOR RESIDUE MG A 3815 source : BC6 3) chain D residue 205 type sequence N description BINDING SITE FOR RESIDUE MG A 3817 source : BC8 4) chain 5 residue 228 type sequence K description BINDING SITE FOR RESIDUE MG A 3850 source : FC4 5) chain K residue 24 type sequence K description BINDING SITE FOR RESIDUE MG A 3851 source : FC5 6) chain E residue 361 type sequence K description BINDING SITE FOR RESIDUE MG A 3866 source : GC9 7) chain e residue 2 type sequence G description BINDING SITE FOR RESIDUE MG A 3893 source : JC8 8) chain 8 residue 39 type sequence D description BINDING SITE FOR RESIDUE MG A 3916 source : MC4 9) chain D residue 198 type sequence K description BINDING SITE FOR RESIDUE MG A 3919 source : MC7 10) chain D residue 200 type sequence R description BINDING SITE FOR RESIDUE MG A 3919 source : MC7 11) chain c residue 33 type sequence Q description BINDING SITE FOR RESIDUE MG A 3930 source : NC9 12) chain F residue 99 type sequence G description BINDING SITE FOR RESIDUE MG A 3944 source : PC5 13) chain M residue 49 type sequence N description BINDING SITE FOR RESIDUE MG M 201 source : RC4 14) chain Q residue 14 type sequence N description BINDING SITE FOR RESIDUE MG Q 301 source : RC5 15) chain a residue 44 type sequence C description BINDING SITE FOR RESIDUE ZN a 200 source : RC6 16) chain a residue 47 type sequence C description BINDING SITE FOR RESIDUE ZN a 200 source : RC6 17) chain a residue 49 type sequence T description BINDING SITE FOR RESIDUE ZN a 200 source : RC6 18) chain a residue 81 type sequence C description BINDING SITE FOR RESIDUE ZN a 200 source : RC6 19) chain a residue 84 type sequence C description BINDING SITE FOR RESIDUE ZN a 200 source : RC6 20) chain c residue 22 type sequence C description BINDING SITE FOR RESIDUE ZN c 100 source : RC7 21) chain c residue 25 type sequence C description BINDING SITE FOR RESIDUE ZN c 100 source : RC7 22) chain c residue 37 type sequence C description BINDING SITE FOR RESIDUE ZN c 100 source : RC7 23) chain c residue 39 type sequence S description BINDING SITE FOR RESIDUE ZN c 100 source : RC7 24) chain c residue 40 type sequence C description BINDING SITE FOR RESIDUE ZN c 100 source : RC7 25) chain f residue 20 type sequence C description BINDING SITE FOR RESIDUE ZN f 100 source : RC8 26) chain f residue 23 type sequence C description BINDING SITE FOR RESIDUE ZN f 100 source : RC8 27) chain f residue 34 type sequence C description BINDING SITE FOR RESIDUE ZN f 100 source : RC8 28) chain f residue 39 type sequence C description BINDING SITE FOR RESIDUE ZN f 100 source : RC8 29) chain h residue 39 type sequence C description BINDING SITE FOR RESIDUE ZN h 100 source : RC9 30) chain h residue 42 type sequence C description BINDING SITE FOR RESIDUE ZN h 100 source : RC9 31) chain h residue 57 type sequence C description BINDING SITE FOR RESIDUE ZN h 100 source : RC9 32) chain h residue 60 type sequence C description BINDING SITE FOR RESIDUE ZN h 100 source : RC9 33) chain i residue 12 type sequence C description BINDING SITE FOR RESIDUE ZN i 201 source : SC1 34) chain i residue 14 type sequence N description BINDING SITE FOR RESIDUE ZN i 201 source : SC1 35) chain i residue 16 type sequence C description BINDING SITE FOR RESIDUE ZN i 201 source : SC1 36) chain i residue 73 type sequence C description BINDING SITE FOR RESIDUE ZN i 201 source : SC1 37) chain i residue 76 type sequence C description BINDING SITE FOR RESIDUE ZN i 201 source : SC1 38) chain h residue 39-60 type ZN_FING sequence CTFCGKTATKRTCVGIWKCKKC description C4-type source Swiss-Prot : SWS_FT_FI1 39) chain S residue 50-67 type prosite sequence KRLIMPKRYRPPLSLSKL description RIBOSOMAL_L18E Ribosomal protein L18e signature. KrLimPKryRPpLSLsKL source prosite : PS01106 40) chain E residue 206-229 type prosite sequence FNPNEMIDVISVTKGHGTKGVVSR description RIBOSOMAL_L3 Ribosomal protein L3 signature. FnpnemiDviSvTkGHGtkGvvsR source prosite : PS00474 41) chain b residue 56-66 type prosite sequence PYEKRIIELIK description RIBOSOMAL_L36E Ribosomal protein L36e signature. PYEKRiIELIK source prosite : PS01190 42) chain e residue 30-46 type prosite sequence KNTKRRHWRR description RIBOSOMAL_L39E Ribosomal protein L39e signature. KKdtkIryNtkrRHWRR source prosite : PS00051 43) chain 8 residue 17-37 type prosite sequence FTRFQSNRFMRVKPAWRKPRG description RIBOSOMAL_L32E Ribosomal protein L32e signature. FtRfqsnRfmRVkpa..WRKprG source prosite : PS00580 44) chain c residue 7-26 type prosite sequence GTGSFGKRNGKTHFLCLRCG description RIBOSOMAL_L37E Ribosomal protein L37e signature. GTgSfGkRngkt.HflClRCG source prosite : PS01077 45) chain a residue 15-28 type prosite sequence TKSNKVRPVRTPGG description RIBOSOMAL_L34E Ribosomal protein L34e signature. TkSnKvrpvRTPGG source prosite : PS01145 46) chain 6 residue 23-47 type prosite sequence SGKYQFGRKSCLKALRTGKGKLVIV description RIBOSOMAL_L30E_1 Ribosomal protein L30e signature 1. SgkyqfGrKscLKalRtGkgKlVIV source prosite : PS00709 47) chain 6 residue 79-99 type prosite sequence DLGTACGKLFRISCLVITDVG description RIBOSOMAL_L30E_2 Ribosomal protein L30e signature 2. DLGTacGKlfriscLvItDvG source prosite : PS00993 48) chain L residue 69-83 type prosite sequence RLGKGFTFEELKGAG description RIBOSOMAL_L13E Ribosomal protein L13e signature. RlGKGFTFeELkgaG source prosite : PS01104 49) chain Y residue 168-183 type prosite sequence KKAYVRLSGEHDALEV description RIBOSOMAL_L23 Ribosomal protein L23 signature. KKAYVRLSgehdaleV source prosite : PS00050 50) chain D residue 197-208 type prosite sequence PKVRGVAMNPVE description RIBOSOMAL_L2 Ribosomal protein L2 signature. PkvRGVAmNPvE source prosite : PS00467 51) chain P residue 46-69 type prosite sequence DKARRLGYKAIQGFVIYRVRVRRG description RIBOSOMAL_L15E Ribosomal protein L15e signature. DKARrLGYkAiqGFVIYRvRVrRG source prosite : PS01194 52) chain i residue 62-73 type prosite sequence KTTKKIVLKLEC description RIBOSOMAL_L44E Ribosomal protein L44e signature. KtTKKivLKleC source prosite : PS01172 53) chain V residue 38-63 type prosite sequence GDYVDIVCDSTQQKGMPFNYYHGKTG description RIBOSOMAL_L21E Ribosomal protein L21e signature. GDyVdivcdstqqk.GmpFnyYhGkTG source prosite : PS01171 54) chain 7 residue 57-71 type prosite sequence VRLDVKLNKFIWSKG description RIBOSOMAL_L31E Ribosomal protein L31e signature. VRLDvkLNkFiWsKG source prosite : PS01144 55) chain O residue 109-141 type prosite sequence KVLGNGKLKHNQPIVVKARYFSSVAEKKIKAVG description RIBOSOMAL_L15 Ribosomal protein L15 signature. KVLGnGkLkhnqpIvVkaryFSsvAekkIkavG source prosite : PS00475

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