Title
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Cryo-EM structure of the Plasmodium falciparum 80S ribosome bound to the anti-protozoan drug emetine, large subunit |
Classification
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RIBOSOME/INHIBITOR |
Compound
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28S ribosomal RNA |
Source
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ORGANISM_SCIENTIFIC: Plasmodium falciparum; |
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Sequence
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0: |
VKTEACSFSEYRIYPGRGQKYIARDGKVYFYLSSKFASLA
LQKKKAAKLRWTQTWRRNNKKT
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1: |
GKLLKPGKVIIILNGRRAGKKAVIVNTYEGQTRERPYSYC
LVAGIEKHPLKVNKSMTKKKIVKRSKVKAFIKCINVNHIL
PTRYQVANDFDIKSLASDDVLKSKNKKKEVKKLGKIFRDK
FLEPVEVSKDISFLHKKLYF
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2: |
SNVSNALVWELTRKSNCFIKKNKAGKKGVFLCDPLNVNYK
NTPSSSGLVKSNSTNVTLKDGKVVFSVKVNQHFKMKNVEK
LLQQHGSKNKEKLLKKYKRLSKLY
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3: |
NVKAYELRTLKKKELLDKLDELKKELSGLRISKALGNSAK
NSKIHGVRKNVARVLTVYNQKRKMELRQLYKNKKFKPYNL
RKKLTKNKRLQLSPKQKAAMTLRQKKKVQNFPQRKYLVV
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4: |
AKSKNHTNHNQNRKAHKNGIKKPKKHKFMSRKGLDPNFFR
NQKYCLKGIQKKKKELKLKAKQEKNN
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5: |
AAKKIKTLKLINKKKRNDLRQRTLRYEEEYESERKKIIEL
KREARKNNCFYREAEKKVVFVIRLKGVNKLPPKVRSVFRL
LRLLQVHNGVFVKVNKATKEMLKIVEPYVTYGYPTLSTVR
KLLYKRGYVRVGKVRRYARKKIQDNADISKHLGKYNVHGI
EDMVYQLYTCGPVFKKVNNFLWAFKLKPPRKGFKAKRHAF
NEPRPGDWGNREAHINELINRMI
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6: |
SAGDNINAKLQLVMKSGKYQFGRKSCLKALRTGKGKLVIV
SSNCPSIQRSVIEYYAMLSKCGVHDYHGDNNDLGTACGKL
FRISCLVITDVGDSDIIK
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7: |
PVTKFITINLSKLTHKVCYKRKAPRAIKEIRSIAGKLMHT
KDVRLDVKLNKFIWSKGVRNPPKRVRVKLERKRNEKMYTI
VEHVMVDSYKGLVNEC
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8: |
AVKKVGKIIKKRTKKFTRFQSNRFMRVKPAWRKPRGIDCR
VRRRYKGTNLMPSIGYGSNKKTKFLLPNNKYKYVVKNVKE
MEPLIMNHTKYCVQIAHNVSSKKRKQIIERAKQMNVSVIN
AKARL
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9: |
LQAVRLYEKGVILGYKRSQRNQDPNFTLISIKNVNTKKHA
QFYVGKRVAYVYRTTKHHDGVKIKCIWGKVCRTHGNSGVI
RAKFKTHIPPKAFGDRVRILMYP
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D: |
GRVIRGQRKGRGSIFKSHNHHRKGAAKLRHLDYCEKKGYI
KGLVKDIIHDPGRGAPLAKVIFKRTEKYGKKEELIIASEG
MFTGQYISCGTKAPLSVGNILPIGKMPEGTLICNLEHRTG
NRGTLVKASGCYATVVGQSEDGKKTKVRLPSGAKKTIDAK
ARAMVGVVGAGGRIDKPILKAGVAHHKYRVKRNCWPKVRG
VAMNPVEHPHGGGNHQHIGHPSTVSRSAPAGQKVGLIAAR
RTGLLRG
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E: |
SHRKFERPRHGSLGFLPRKRCKRLRGKIRSFPKDDKEKPP
HFTAFMGYKAGMTHIVREVDKPGSKLHKKEIVEACTIIEC
APMVVVGIVGYRETPKGLRILSTVWANHVSDEFRRRYYKN
WYKSEKKAFTKSLNVPEATKNCLLKRIEKYCTVLRAICHT
QPSKTPLRMKKAHIMEVQINGGSMKEKLEFVKEMLEKNLP
VSTVFNPNEMIDVISVTKGHGTKGVVSRYGVKRLPRKTHR
GLRKVACIGAWHPARVQFQIPRHGQKGYFHRTERNKKIYR
IGLKTDKNSASTDADITEKKITPMGGFPHYGVVNEDFLLL
KGCVAGTKKRPITLRKNIVPQVSRDALAQVSLKFIDTSSK
IGHGRFQTSEEKVKYYGPLK
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F: |
PVANVYSTNGKNVVGEVEIPVVFQTPIRNDLIQSVYTNMS
KNRRHPYAVKLGAGYETSAESWGTGRAVARIPRVPGGGTH
RAGQGAFGNMCRGGGMFNPTKIWRRWGRKVNLKEKRYAVC
SSIAASGVTSLVLARGHRISHLKEVPLVVSNDIESLSKTK
EAVNFLVSLGLKDEVNRLVKSKKIRAGKGKMRNRKYKIRN
GPLIIYENDNGVKKAFRNIPGVDLCKVTKLNLLKLAPGGS
IGRLCIWSESAFKKLDVIYGKIHEKKVTKKNYILPKSIVH
NPDIYRIIHSDKVQASLLAKKKPCKKRLQNKNSLTNFAVR
CRLNPAYKLLRSLAVLRMRKSILEKSKNKKEKRVQKQIQK
KELQKINHDYYKGVAKAVKKKKKREEKKAK
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G: |
VMREIKVNKLVLNICVGESGDRLTRAARVLEQLTEQKPIF
GKCRKISCFVTVRGKKALEILEKGLKRRKNFSDTGNFGFG
IGMDFYVHLSRSGYRVTRRTRRRSKISKTHKVTKEDAMKW
FQTK
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H: |
KTIVSTQKVLIPEGVKVAINARKVTVSGKYGTLRRSFRHL
PIDIRLNKLKKYIKVVMWFGVPDSLACIRTVCTHLKNMFT
GVTKKFLYKMRLVHAHFPINSNIVDNNTRIEIRNYLGEKS
VRFVKALPGVVIEKSPNVKDEIYVSGADIENVSLTAALIH
QSVLCRNKDIRKFLDGIYVSEVTTV
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I: |
KHYNVKGKKKVLVPVNAKKTINKKYFGRKVASKKKYVVQR
KLRKSIEVGKVAIILTGKHMGKRCIITKILNSGLLAVVGP
YEINGVPLKRVDSRYLVVTSTNIFNFENIAKLKDDFLNYA
QDIDDDSFIKTLEIKKKQKKLLKFMNNVIDKIKEIRKEDP
KVQKLEGIQKDIGSLLKPEILKNKVFAHYLKSKFTLRNDM
VLHKMKF
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J: |
KDNPLIFEKKKRSNIIGVGVRPKKDLSKYVKWPRYIRIQR
KKKILLQRLKVPPSINQFNHTLPKSQTQDLLNFLKAYKPE
SKTDKKQRLLNKLFLKYGINHITKLVENKKANLVVIANDV
SPIELVLFLPALCRLKEVPYCIVKDKATLGKLVHKKTATA
VCLESVKKEDQEKLDYFAKVCKENFNDNVDLRRKWGGQKM
SAKSMLLKKMKDKARKIEEAKKKEISAKL
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K: |
MYKKEYVIDCKGHLLGRLASLIAKELLNGQRIVAVRCEDI
NISGSLYRNKLKYQEFLRLRTNTNPKKGPLHLREPSKILW
RCVRGMLPHKTYKGQLALKKLKVCVGMPYPYDKKKKYVLP
SALRAFRLKKHRRYCRLGTLSSRVGWNYDTLVKKNEVLRK
QVSKAYYKKKVNNLNEKKEIKTEALNLINPEQRQVLENFG
Y
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L: |
VAHNNVLPNVHLHKWWQRHVRVNFSKNIKKKKRRLLREKR
RKANGGTPIEKLHPIVHCPTQRYNFRTRLGKGFTFEELKG
AGLTPRAAQTIGICYDKRRKNRSEESLTKNVERLLKYKNS
LVMIPLKKNKAKKGIGGIPADADKNTIKEFRNKKPLLSIF
KKEKNTKPFYETIEVSKIDKEFLAYKTLRRAKLAERRKNR
RQQKKDIKFKS
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M: |
TLKNKMRITLSLPVGALINCCDNSGGKNLYIIAVQGFGSC
LNRLPAASLGDMVLATVKKGKPDLRKKVLNAIICRQSKAW
RRHEGYYIYFEDNAGVIVNPKGEMKGSAITGPVARECAEL
WPKLSSAASAIV
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N: |
VELTEEELYISKKNLLFKRFVEPGRLCLIEYGPYAGKLCF
IVDIVTITRVIVDGAFITGVPRMVIPLKRLKLLKERIKIN
KNCKSGFLRKTVNSTKVLEEFNNSKLGKKMIIKKKRDEAT
DFERFQVYFAKRELKKKMTTIKNKKN
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O: |
ATRFKKNRKKRGHVSAGHGRVGKHRKHPGGRGKAGGLHHM
RINFDKYHPGYFGKVGMRHLNLLKNRTYCPTINVDKLWGL
LPEEKKKEFSENKDIAPVIDVTRKGYFKVLGNGKLKHNQP
IVVKARYFSSVAEKKIKAVGGQCILVA
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P: |
GAYKYIQEIWKKKQSDAMHFLLRVRTWEYRQLPVVHRVSK
PSRPDKARRLGYKAIQGFVIYRVRVRRGDRKKRVKKGIVH
GKPKHQGVHKQKSTRNLKSVAEGKVGKSICGNLRVLNSYW
VGQDAVYKYYEVILVDPNHNAVRNNPKINWICNPVHKHRE
LRGLTSAGKKYRGLRVKGHLSAKSRPSIRANWKRRQLIKL
RKCR
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Q: |
GRRPARCYRYCKNKPYPKSRYCRGVPDPKIRIYDMGRKKA
DVNEFSGVVHLVSYEYEQISSEALEAARISANKYMITNCG
KDNFHLRVRIHPFHVLRINKAFGKPNGVVARVDIGQVLLS
IRTKENFVSKACEALRRAKYKFPGRQKVFVSNKWGFTPFS
KDEYQQYKKKGRIISDGVSCKFIREKGPL
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R: |
KVVKNKAYFKRYQVKYRRRREGKTDYRARKALILQDKNKY
NAQKLRFVVRKTNSQVICQIACAHIEGDKILAEAKSKELI
RYGIPVGLKNYAAAYATGLLCARRFLKSLNLDTQFLGVEK
VTRKPIKAFLDVGITRTTTGNRVFAALKGACDGGLNIPHG
NNRFPGSFNPEQLRKNILGIHVAEYMKTLQEEDNDKYKTH
FNDYLKNNIGADDIEQMYLNAHEKIRQNPKKLNAKLRKKR
VKEKLALYVELQ
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S: |
GIALKNVGRIKKHGRKHLVSKNPYLRLLVKLYNFLARRTN
ANFNKIIAKRLIMPKRYRPPLSLSKLQYHMANHPNDIAVV
VGSITDDKRLFSLKQLKVCALRFTETARKRIEDAGGECLT
FDQLALKYPTGKKCVLLRGPTKARTAEKHFGKAPGKPKSK
ARPYVRSKGRKFEKARGRRKSRAYKK
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T: |
SLTLQKRLAASVLKCGKNKIWMDPNEISEISLANSRFSIR
KLYKEGLILKKPQKVHSRARVRLYKLAKRKGRHMGIGKRK
GTKNARTNQKTLWIKRQRVLRRLLKRLRDSKKVDRHLYHS
FYLKCKGNQFKNKRTLIEAIQREKNETLKKKAIADQLEAK
RLKAQVLRNKRKLKKDKEVVA
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U: |
IDNSLNTNIHQYHIVGRAIPTAKDKNPNVYRMCIFAKNDT
NAKSRFWYFMKKINKLKKSNGELLACEQIKERFPLRVKNY
GVLLRYDSRTGTHNMYKEFRDTTKEGAIAQLYSEMAGRHR
ARASSINIIRISEISSSLVRRPHIKQLLKRRLRFPALHLP
TLQKEYRKKFASKRPSTYRM
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V: |
KSRGKRSGTRYKFSKKFRKHGECTANKYLEKLNYGDYVDI
VCDSTQQKGMPFNYYHGKTGKIFHITKRGVGVLVNKRVKH
RIEQKKVCVRIEHVRKSRCNEDFLLRKIKNAELIKEAKLK
NEHINIKRKTEGPKPAAMIKVPPSKIITIEPLPFY
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W: |
YAKKIRNLGKCAKGAGVDLRVHFKNTYEAARAIRRMKLLE
AKKYLNDVIEKKRCVPFRKYNGGVGRTNQAKEFNHTQGRW
PAKSCKFLLNILDNVQANAESRNLDVSKLRLIHVMVNKAR
PGRRRTYKAHGRINPFMSSPCHIQIIAREINISNQNRLKN
KSVKKQQTVQ
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X: |
IKYVLDCTKPVKDTILDISGLEQFFKDKIKVDKKTNNLKN
KVVVTSDEYKIYITVHIPFSKRYIKYLAKKYIKMHQIRDF
LRVIAKGKLAYEFKYFQ
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Y: |
ARNPKCPRIVKSCHSKTLDKYGLIKYPLTSEKAMKKIEEI
NTLVFMCDKRANKKNIKKSVKNLFGIECDKVNVLNTLNGD
KKAYVRLSGEHDALEVANKIG
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Z: |
KFNKQKSSSRRKMRKAHFTAPAGLRRKIMSSKLSKELRLK
YKTRSLPVRKDDEVLICRGHNHGREGKVVKINRKRYKIYV
ERVTREKVNGESTFIGIHPSNVVLTKLKVDKNRKKILDRK
A
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a: |
AQRVHYRRHNHYNTKSNKVRPVRTPGGKLTIHVVKKKAGK
PKCADCKTAIQGVKALRPADNYRARRKNRTVARAYGGSIC
ARCIRERIMRAFLFEEQKCVRQVLKE
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b: |
GRKSTIKPATGIAVGFNSGHVVTKRNSKRKELIKDVVREI
TGFSPYEKRIIELIKIGTSASTKRSLKYAKKKLGTHKRGK
AKREEIQKVVILQRR
|
c: |
GKAGKGTGSFGKRNGKTHFLCLRCGKRSYHLQKKKCASCG
YPSAKKRRFNWSVKAKRRNTTGTGRCRYIKTLRRKLKNKF
TEGSTPKPK
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d: |
PKQITDIRKFLKISRKPDTTAVIIMKKKSKTVITKLKLRT
KKYLYTMVFADRKKAERIENSLLPSLKRIYYP
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e: |
GSIKRFRLKQRLGKCRRQNRPVPHWYRLKNTKRRHWRRTK
LGL
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f: |
AIEPSLAQLAQKYNCQKLICRKCYARLHPRATNCRNKKCG
RTNQLRPKKKL
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g: |
HGASRYKKSRAKMRWKWKKKRTRRLQKKRRKMRQRSR
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h: |
SRRTKKVGLTGKYGTRYGSSLRKQIKKIELMQHAKYLCTF
CGKTATKRTCVGIWKCKKCKRKVCGGAWSLTTPAAVAAKS
TIIRL
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i: |
VNVPKTRKTYCSNKCKKHTMHKVSQYKKGKERLSSLGRRR
YDMKQKGFGGQTKPVFKKKAKTTKKIVLKLECTKCKKKRF
QTMKRCKTFEMGADK
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Description
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