eF-site ID 3iu3-ABCDHIJKL PDB Code 3iu3 Chain A, B, C, D, H, I, J, K, L click to enlarge Title Crystal structure of the Fab fragment of therapeutic antibody Basiliximab in complex with IL-2Ra (CD25) ectodomain Classification IMMUNE SYSTEM Compound Heavy chain of Fab fragment of Basiliximab Source Homo sapiens (Human) (IL2RA_HUMAN) Sequence A:  QLQQSGTVLARPGASVKMSCKASGYSFTRYWMHWIKQRPG QGLEWIGAIYPGNSDTSYNQKFEGKAKLTAVTSASTAYME LSSLTHEDSAVYYCSRDYGYYFDFWGQGTTLTVSSASTKG PSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGA LTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNV NHKPSNTKVDKRVEP B:  QIVSTQSPAIMSASPGEKVTMTCSASSSRSYMQWYQQKPG TSPKRWIYDTSKLASGVPARFSGSGSGTSYSLTISSMEAE DAATYYCHQRSSYTFGGGTKLEIKRTVAAPSVFIFPPSDE QLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESV TEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSS PVTKSFNR C:  QLQQSGTVLARPGASVKMSCKASGYSFTRYWMHWIKQRPG QGLEWIGAIYPGNSDTSYNQKFEGKAKLTAVTSASTAYME LSSLTHEDSAVYYCSRDYGYYFDFWGQGTTLTVSSASTKG PSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGA LTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNV NHKPSNTKVDKRVEP D:  QIVSTQSPAIMSASPGEKVTMTCSASSSRSYMQWYQQKPG TSPKRWIYDTSKLASGVPARFSGSGSGTSYSLTISSMEAE DAATYYCHQRSSYTFGGGTKLEIKRTVAAPSVFIFPPSDE QLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESV TEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSS PVTKSFNRG H:  QLQQSGTVLARPGASVKMSCKASGYSFTRYWMHWIKQRPG QGLEWIGAIYPGNSDTSYNQKFEGKAKLTAVTSASTAYME LSSLTHEDSAVYYCSRDYGYYFDFWGQGTTLTVSSASTKG PSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGA LTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNV NHKPSNTKVDKRVEP I:  ELCDDDPPEIPHATFKAMAYKEGTMLNCECKRGFRRIKSG SLYMLCTGNSSHSSWDNQCQCPGHCREPPPWENEATERIY HFVVGQMVYYQCVQGYRALHRGPAESVCKMTHGKTRWTQ J:  ELCDDDPPEIPHATFKAMAYKEGTMLNCECKRGIKSGSLY MLCTGNSSHSSWDNQCQCTSHCREPPPWENEATERIYHFV VGQMVYYQCVQGYRALHRGPAESVCKMTHGKTRWTQ K:  ELCDDDPPEIPHATFKAMAYKEGTMLNCECRIKSGSLYML CTGNSSHSSWDNQCQCTSPGHCREPPPWENEATERIYHFV VGQMVYYQCVQGYRALHRGPAESVCKMTHGKTRW L:  QIVSTQSPAIMSASPGEKVTMTCSASSSRSYMQWYQQKPG TSPKRWIYDTSKLASGVPARFSGSGSGTSYSLTISSMEAE DAATYYCHQRSSYTFGGGTKLEIKRTVAAPSVFIFPPSDE QLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESV TEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSS PVTKSFNR Description Functional site 1) chain I residue 49 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:3134887 source Swiss-Prot : SWS_FT_FI1 2) chain J residue 49 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:3134887 source Swiss-Prot : SWS_FT_FI1 3) chain K residue 49 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:3134887 source Swiss-Prot : SWS_FT_FI1 4) chain B residue 189-195 type prosite sequence YACEVTH description IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YACEVTH source prosite : PS00290 5) chain A residue 196-202 type prosite sequence YICNVNH description IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YACEVTH source prosite : PS00290

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