eF-site ID 3in7-A PDB Code 3in7 Chain A click to enlarge Title Crystal Structure of the Grb2 SH2 Domain in Complex with a Cyclopropyl-constrained Ac-pY-Q-N-NH2 Tripeptide Mimic Classification SIGNALING PROTEIN/PEPTIDE Compound Growth factor receptor-bound protein 2 Source Homo sapiens (Human) (GRB2_HUMAN) Sequence A:  MKPHPWFFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGD FSLSVKFGNDVQHFKVLRDGAGKYFLWVVKFNSLNELVDY HRSTSVSRNQQIFLRDIEQ Description Functional site 1) chain A residue 67 type sequence R description BINDING SITE FOR RESIDUE AYQ A 1 source : AC1 2) chain A residue 86 type sequence R description BINDING SITE FOR RESIDUE AYQ A 1 source : AC1 3) chain A residue 88 type sequence S description BINDING SITE FOR RESIDUE AYQ A 1 source : AC1 4) chain A residue 90 type sequence S description BINDING SITE FOR RESIDUE AYQ A 1 source : AC1 5) chain A residue 96 type sequence S description BINDING SITE FOR RESIDUE AYQ A 1 source : AC1 6) chain A residue 106 type sequence Q description BINDING SITE FOR RESIDUE AYQ A 1 source : AC1 7) chain A residue 107 type sequence H description BINDING SITE FOR RESIDUE AYQ A 1 source : AC1 8) chain A residue 108 type sequence F description BINDING SITE FOR RESIDUE AYQ A 1 source : AC1 9) chain A residue 109 type sequence K description BINDING SITE FOR RESIDUE AYQ A 1 source : AC1 10) chain A residue 120 type sequence L description BINDING SITE FOR RESIDUE AYQ A 1 source : AC1 11) chain A residue 121 type sequence W description BINDING SITE FOR RESIDUE AYQ A 1 source : AC1 12) chain A residue 142 type sequence R description BINDING SITE FOR RESIDUE AYQ A 1 source : AC1 13) chain A residue 143 type sequence N description BINDING SITE FOR RESIDUE AYQ A 1 source : AC1 14) chain A residue 109 type MOD_RES sequence K description N6-acetyllysine => ECO:0007744|PubMed:19608861 source Swiss-Prot : SWS_FT_FI1

Display surface Download Links