eF-site ID 3ii0-ABCD PDB Code 3ii0 Chain A, B, C, D click to enlarge Title Crystal structure of human Glutamate oxaloacetate transaminase 1 (GOT1) Classification TRANSFERASE Compound Aspartate aminotransferase, cytoplasmic Source Homo sapiens (Human) (AATC_HUMAN) Sequence A:  PVLVFKLTADFREDPDPRKVNLGVGAYRTDDCHPWVLPVV KKVEQKIANDNSLNHEYLPILGLAEFRSCASRLALGDDSP ALKEKRVGGVQSLGGTGALRIGADFLARWYNGTNNKNTPV YVSSPTWENHNAVFSAAGFKDIRSYRYWDAEKRGLDLQGF LNDLENAPEFSIVVLHACAHNPTGIDPTPEQWKQIASVMK HRFLFPFFDSAYQGFASGNLERDAWAIRYFVSEGFEFFCA QSFSKNFGLYNERVGNLTVVGKEPESILQVLSQMEKIVRI TWSNPPAQGARIVASTLSNPELFEEWTGNVKTMADRILTM RSELRARLEALKTPGTWNHITDQIGMFSFTGLNPKQVEYL VNEKHIYLLPSGRINVSGLTTKNLDYVATSIHEAVTKIAE NLYFQ B:  PVLVFKLTADFREDPDPRKVNLGVGAYRTDDCHPWVLPVV KKVEQKIANDNSLNHEYLPILGLAEFRSCASRLALGDDSP ALKEKRVGGVQSLGGTGALRIGADFLARWYNGTNNKNTPV YVSSPTWENHNAVFSAAGFKDIRSYRYWDAEKRGLDLQGF LNDLENAPEFSIVVLHACAHNPTGIDPTPEQWKQIASVMK HRFLFPFFDSAYQGFASGNLERDAWAIRYFVSEGFEFFCA QSFSKNFGLYNERVGNLTVVGKEPESILQVLSQMEKIVRI TWSNPPAQGARIVASTLSNPELFEEWTGNVKTMADRILTM RSELRARLEALKTPGTWNHITDQIGMFSFTGLNPKQVEYL VNEKHIYLLPSGRINVSGLTTKNLDYVATSIHEAVTKIAE NLYFQ C:  MQPVLVFKLTADFREDPDPRKVNLGVGAYRTDDCHPWVLP VVKKVEQKIANDNSLNHEYLPILGLAEFRSCASRLALGDD SPALKEKRVGGVQSLGGTGALRIGADFLARWYNGTNNKNT PVYVSSPTWENHNAVFSAAGFKDIRSYRYWDAEKRGLDLQ GFLNDLENAPEFSIVVLHACAHNPTGIDPTPEQWKQIASV MKHRFLFPFFDSAYQGFASGNLERDAWAIRYFVSEGFEFF CAQSFSKNFGLYNERVGNLTVVGKEPESILQVLSQMEKIV RITWSNPPAQGARIVASTLSNPELFEEWTGNVKTMADRIL TMRSELRARLEALKTPGTWNHITDQIGMFSFTGLNPKQVE YLVNEKHIYLLPSGRINVSGLTTKNLDYVATSIHEAVTKI AENLYFQ D:  MQPVLVFKLTADFREDPDPRKVNLGVGAYRTDDCHPWVLP VVKKVEQKIANDNSLNHEYLPILGLAEFRSCASRLALGDD SPALKEKRVGGVQSLGGTGALRIGADFLARWYNGTNNKNT PVYVSSPTWENHNAVFSAAGFKDIRSYRYWDAEKRGLDLQ GFLNDLENAPEFSIVVLHACAHNPTGIDPTPEQWKQIASV MKHRFLFPFFDSAYQGFASGNLERDAWAIRYFVSEGFEFF CAQSFSKNFGLYNERVGNLTVVGKEPESILQVLSQMEKIV RITWSNPPAQGARIVASTLSNPELFEEWTGNVKTMADRIL TMRSELRARLEALKTPGTWNHITDQIGMFSFTGLNPKQVE YLVNEKHIYLLPSGRINVSGLTTKNLDYVATSIHEAVTKI AENLYFQ Description Functional site 1) chain A residue 108 type sequence G description BINDING SITE FOR RESIDUE PLP A 1 source : AC1 2) chain A residue 109 type sequence G description BINDING SITE FOR RESIDUE PLP A 1 source : AC1 3) chain A residue 110 type sequence T description BINDING SITE FOR RESIDUE PLP A 1 source : AC1 4) chain A residue 141 type sequence W description BINDING SITE FOR RESIDUE PLP A 1 source : AC1 5) chain A residue 195 type sequence N description BINDING SITE FOR RESIDUE PLP A 1 source : AC1 6) chain A residue 223 type sequence D description BINDING SITE FOR RESIDUE PLP A 1 source : AC1 7) chain A residue 225 type sequence A description BINDING SITE FOR RESIDUE PLP A 1 source : AC1 8) chain A residue 226 type sequence Y description BINDING SITE FOR RESIDUE PLP A 1 source : AC1 9) chain A residue 256 type sequence S description BINDING SITE FOR RESIDUE PLP A 1 source : AC1 10) chain A residue 258 type sequence S description BINDING SITE FOR RESIDUE PLP A 1 source : AC1 11) chain A residue 259 type sequence K description BINDING SITE FOR RESIDUE PLP A 1 source : AC1 12) chain A residue 267 type sequence R description BINDING SITE FOR RESIDUE PLP A 1 source : AC1 13) chain D residue 71 type sequence Y description BINDING SITE FOR RESIDUE PLP A 1 source : AC1 14) chain A residue 18 type sequence V description BINDING SITE FOR RESIDUE TAR A 435 source : AC2 15) chain A residue 19 type sequence F description BINDING SITE FOR RESIDUE TAR A 435 source : AC2 16) chain A residue 38 type sequence V description BINDING SITE FOR RESIDUE TAR A 435 source : AC2 17) chain A residue 39 type sequence G description BINDING SITE FOR RESIDUE TAR A 435 source : AC2 18) chain A residue 141 type sequence W description BINDING SITE FOR RESIDUE TAR A 435 source : AC2 19) chain A residue 195 type sequence N description BINDING SITE FOR RESIDUE TAR A 435 source : AC2 20) chain A residue 226 type sequence Y description BINDING SITE FOR RESIDUE TAR A 435 source : AC2 21) chain A residue 259 type sequence K description BINDING SITE FOR RESIDUE TAR A 435 source : AC2 22) chain A residue 361 type sequence F description BINDING SITE FOR RESIDUE TAR A 435 source : AC2 23) chain A residue 387 type sequence R description BINDING SITE FOR RESIDUE TAR A 435 source : AC2 24) chain D residue 71 type sequence Y description BINDING SITE FOR RESIDUE TAR A 435 source : AC2 25) chain D residue 293 type sequence R description BINDING SITE FOR RESIDUE TAR A 435 source : AC2 26) chain A residue 128 type sequence N description BINDING SITE FOR RESIDUE EDO A 3 source : AC3 27) chain A residue 130 type sequence K description BINDING SITE FOR RESIDUE EDO A 3 source : AC3 28) chain A residue 41 type sequence Y description BINDING SITE FOR RESIDUE EDO A 11 source : AC4 29) chain A residue 43 type sequence T description BINDING SITE FOR RESIDUE EDO A 11 source : AC4 30) chain A residue 49 type sequence W description BINDING SITE FOR RESIDUE EDO A 11 source : AC4 31) chain A residue 78 type sequence A description BINDING SITE FOR RESIDUE EDO A 436 source : AC5 32) chain A residue 81 type sequence R description BINDING SITE FOR RESIDUE EDO A 436 source : AC5 33) chain A residue 82 type sequence S description BINDING SITE FOR RESIDUE EDO A 436 source : AC5 34) chain A residue 85 type sequence S description BINDING SITE FOR RESIDUE EDO A 436 source : AC5 35) chain A residue 102 type sequence G description BINDING SITE FOR RESIDUE EDO A 436 source : AC5 36) chain A residue 103 type sequence G description BINDING SITE FOR RESIDUE EDO A 436 source : AC5 37) chain B residue 108 type sequence G description BINDING SITE FOR RESIDUE PLP B 2 source : AC6 38) chain B residue 109 type sequence G description BINDING SITE FOR RESIDUE PLP B 2 source : AC6 39) chain B residue 110 type sequence T description BINDING SITE FOR RESIDUE PLP B 2 source : AC6 40) chain B residue 141 type sequence W description BINDING SITE FOR RESIDUE PLP B 2 source : AC6 41) chain B residue 195 type sequence N description BINDING SITE FOR RESIDUE PLP B 2 source : AC6 42) chain B residue 223 type sequence D description BINDING SITE FOR RESIDUE PLP B 2 source : AC6 43) chain B residue 225 type sequence A description BINDING SITE FOR RESIDUE PLP B 2 source : AC6 44) chain B residue 226 type sequence Y description BINDING SITE FOR RESIDUE PLP B 2 source : AC6 45) chain B residue 256 type sequence S description BINDING SITE FOR RESIDUE PLP B 2 source : AC6 46) chain B residue 258 type sequence S description BINDING SITE FOR RESIDUE PLP B 2 source : AC6 47) chain B residue 259 type sequence K description BINDING SITE FOR RESIDUE PLP B 2 source : AC6 48) chain B residue 267 type sequence R description BINDING SITE FOR RESIDUE PLP B 2 source : AC6 49) chain C residue 71 type sequence Y description BINDING SITE FOR RESIDUE PLP B 2 source : AC6 50) chain B residue 18 type sequence V description BINDING SITE FOR RESIDUE TAR B 435 source : AC7 51) chain B residue 19 type sequence F description BINDING SITE FOR RESIDUE TAR B 435 source : AC7 52) chain B residue 38 type sequence V description BINDING SITE FOR RESIDUE TAR B 435 source : AC7 53) chain B residue 39 type sequence G description BINDING SITE FOR RESIDUE TAR B 435 source : AC7 54) chain B residue 141 type sequence W description BINDING SITE FOR RESIDUE TAR B 435 source : AC7 55) chain B residue 195 type sequence N description BINDING SITE FOR RESIDUE TAR B 435 source : AC7 56) chain B residue 226 type sequence Y description BINDING SITE FOR RESIDUE TAR B 435 source : AC7 57) chain B residue 259 type sequence K description BINDING SITE FOR RESIDUE TAR B 435 source : AC7 58) chain B residue 387 type sequence R description BINDING SITE FOR RESIDUE TAR B 435 source : AC7 59) chain C residue 71 type sequence Y description BINDING SITE FOR RESIDUE TAR B 435 source : AC7 60) chain C residue 293 type sequence R description BINDING SITE FOR RESIDUE TAR B 435 source : AC7 61) chain B residue 41 type sequence Y description BINDING SITE FOR RESIDUE EDO B 1 source : AC8 62) chain B residue 43 type sequence T description BINDING SITE FOR RESIDUE EDO B 1 source : AC8 63) chain B residue 49 type sequence W description BINDING SITE FOR RESIDUE EDO B 1 source : AC8 64) chain B residue 128 type sequence N description BINDING SITE FOR RESIDUE EDO B 10 source : AC9 65) chain B residue 130 type sequence K description BINDING SITE FOR RESIDUE EDO B 10 source : AC9 66) chain B residue 78 type sequence A description BINDING SITE FOR RESIDUE EDO B 436 source : BC1 67) chain B residue 81 type sequence R description BINDING SITE FOR RESIDUE EDO B 436 source : BC1 68) chain B residue 82 type sequence S description BINDING SITE FOR RESIDUE EDO B 436 source : BC1 69) chain B residue 103 type sequence G description BINDING SITE FOR RESIDUE EDO B 436 source : BC1 70) chain B residue 71 type sequence Y description BINDING SITE FOR RESIDUE PLP C 3 source : BC2 71) chain C residue 108 type sequence G description BINDING SITE FOR RESIDUE PLP C 3 source : BC2 72) chain C residue 109 type sequence G description BINDING SITE FOR RESIDUE PLP C 3 source : BC2 73) chain C residue 110 type sequence T description BINDING SITE FOR RESIDUE PLP C 3 source : BC2 74) chain C residue 141 type sequence W description BINDING SITE FOR RESIDUE PLP C 3 source : BC2 75) chain C residue 195 type sequence N description BINDING SITE FOR RESIDUE PLP C 3 source : BC2 76) chain C residue 223 type sequence D description BINDING SITE FOR RESIDUE PLP C 3 source : BC2 77) chain C residue 226 type sequence Y description BINDING SITE FOR RESIDUE PLP C 3 source : BC2 78) chain C residue 256 type sequence S description BINDING SITE FOR RESIDUE PLP C 3 source : BC2 79) chain C residue 258 type sequence S description BINDING SITE FOR RESIDUE PLP C 3 source : BC2 80) chain C residue 259 type sequence K description BINDING SITE FOR RESIDUE PLP C 3 source : BC2 81) chain C residue 267 type sequence R description BINDING SITE FOR RESIDUE PLP C 3 source : BC2 82) chain B residue 71 type sequence Y description BINDING SITE FOR RESIDUE TAR C 435 source : BC3 83) chain B residue 293 type sequence R description BINDING SITE FOR RESIDUE TAR C 435 source : BC3 84) chain C residue 18 type sequence V description BINDING SITE FOR RESIDUE TAR C 435 source : BC3 85) chain C residue 19 type sequence F description BINDING SITE FOR RESIDUE TAR C 435 source : BC3 86) chain C residue 38 type sequence V description BINDING SITE FOR RESIDUE TAR C 435 source : BC3 87) chain C residue 39 type sequence G description BINDING SITE FOR RESIDUE TAR C 435 source : BC3 88) chain C residue 141 type sequence W description BINDING SITE FOR RESIDUE TAR C 435 source : BC3 89) chain C residue 195 type sequence N description BINDING SITE FOR RESIDUE TAR C 435 source : BC3 90) chain C residue 226 type sequence Y description BINDING SITE FOR RESIDUE TAR C 435 source : BC3 91) chain C residue 259 type sequence K description BINDING SITE FOR RESIDUE TAR C 435 source : BC3 92) chain C residue 361 type sequence F description BINDING SITE FOR RESIDUE TAR C 435 source : BC3 93) chain C residue 387 type sequence R description BINDING SITE FOR RESIDUE TAR C 435 source : BC3 94) chain A residue 416 type sequence L description BINDING SITE FOR RESIDUE EDO C 5 source : BC4 95) chain C residue 124 type sequence Y description BINDING SITE FOR RESIDUE EDO C 5 source : BC4 96) chain C residue 125 type sequence N description BINDING SITE FOR RESIDUE EDO C 5 source : BC4 97) chain C residue 157 type sequence R description BINDING SITE FOR RESIDUE EDO C 7 source : BC5 98) chain C residue 158 type sequence S description BINDING SITE FOR RESIDUE EDO C 7 source : BC5 99) chain C residue 41 type sequence Y description BINDING SITE FOR RESIDUE EDO C 12 source : BC6 100) chain C residue 326 type sequence T description BINDING SITE FOR RESIDUE EDO C 12 source : BC6 101) chain C residue 81 type sequence R description BINDING SITE FOR RESIDUE EDO C 436 source : BC7 102) chain C residue 103 type sequence G description BINDING SITE FOR RESIDUE EDO C 436 source : BC7 103) chain A residue 71 type sequence Y description BINDING SITE FOR RESIDUE PLP D 4 source : BC8 104) chain D residue 108 type sequence G description BINDING SITE FOR RESIDUE PLP D 4 source : BC8 105) chain D residue 109 type sequence G description BINDING SITE FOR RESIDUE PLP D 4 source : BC8 106) chain D residue 110 type sequence T description BINDING SITE FOR RESIDUE PLP D 4 source : BC8 107) chain D residue 141 type sequence W description BINDING SITE FOR RESIDUE PLP D 4 source : BC8 108) chain D residue 195 type sequence N description BINDING SITE FOR RESIDUE PLP D 4 source : BC8 109) chain D residue 223 type sequence D description BINDING SITE FOR RESIDUE PLP D 4 source : BC8 110) chain D residue 226 type sequence Y description BINDING SITE FOR RESIDUE PLP D 4 source : BC8 111) chain D residue 256 type sequence S description BINDING SITE FOR RESIDUE PLP D 4 source : BC8 112) chain D residue 258 type sequence S description BINDING SITE FOR RESIDUE PLP D 4 source : BC8 113) chain D residue 259 type sequence K description BINDING SITE FOR RESIDUE PLP D 4 source : BC8 114) chain D residue 267 type sequence R description BINDING SITE FOR RESIDUE PLP D 4 source : BC8 115) chain A residue 71 type sequence Y description BINDING SITE FOR RESIDUE TAR D 435 source : BC9 116) chain A residue 293 type sequence R description BINDING SITE FOR RESIDUE TAR D 435 source : BC9 117) chain D residue 18 type sequence V description BINDING SITE FOR RESIDUE TAR D 435 source : BC9 118) chain D residue 19 type sequence F description BINDING SITE FOR RESIDUE TAR D 435 source : BC9 119) chain D residue 39 type sequence G description BINDING SITE FOR RESIDUE TAR D 435 source : BC9 120) chain D residue 141 type sequence W description BINDING SITE FOR RESIDUE TAR D 435 source : BC9 121) chain D residue 195 type sequence N description BINDING SITE FOR RESIDUE TAR D 435 source : BC9 122) chain D residue 226 type sequence Y description BINDING SITE FOR RESIDUE TAR D 435 source : BC9 123) chain D residue 259 type sequence K description BINDING SITE FOR RESIDUE TAR D 435 source : BC9 124) chain D residue 361 type sequence F description BINDING SITE FOR RESIDUE TAR D 435 source : BC9 125) chain D residue 387 type sequence R description BINDING SITE FOR RESIDUE TAR D 435 source : BC9 126) chain D residue 157 type sequence R description BINDING SITE FOR RESIDUE EDO D 6 source : CC1 127) chain D residue 158 type sequence S description BINDING SITE FOR RESIDUE EDO D 6 source : CC1 128) chain D residue 41 type sequence Y description BINDING SITE FOR RESIDUE EDO D 8 source : CC2 129) chain D residue 43 type sequence T description BINDING SITE FOR RESIDUE EDO D 8 source : CC2 130) chain D residue 49 type sequence W description BINDING SITE FOR RESIDUE EDO D 8 source : CC2 131) chain D residue 81 type sequence R description BINDING SITE FOR RESIDUE EDO D 9 source : CC3 132) chain D residue 85 type sequence S description BINDING SITE FOR RESIDUE EDO D 9 source : CC3 133) chain D residue 101 type sequence V description BINDING SITE FOR RESIDUE EDO D 9 source : CC3 134) chain A residue 39 type BINDING sequence G description source Swiss-Prot : SWS_FT_FI1 135) chain C residue 141 type BINDING sequence W description source Swiss-Prot : SWS_FT_FI1 136) chain C residue 195 type BINDING sequence N description source Swiss-Prot : SWS_FT_FI1 137) chain C residue 387 type BINDING sequence R description source Swiss-Prot : SWS_FT_FI1 138) chain D residue 39 type BINDING sequence G description source Swiss-Prot : SWS_FT_FI1 139) chain D residue 141 type BINDING sequence W description source Swiss-Prot : SWS_FT_FI1 140) chain D residue 195 type BINDING sequence N description source Swiss-Prot : SWS_FT_FI1 141) chain D residue 387 type BINDING sequence R description source Swiss-Prot : SWS_FT_FI1 142) chain A residue 141 type BINDING sequence W description source Swiss-Prot : SWS_FT_FI1 143) chain A residue 195 type BINDING sequence N description source Swiss-Prot : SWS_FT_FI1 144) chain A residue 387 type BINDING sequence R description source Swiss-Prot : SWS_FT_FI1 145) chain B residue 39 type BINDING sequence G description source Swiss-Prot : SWS_FT_FI1 146) chain B residue 141 type BINDING sequence W description source Swiss-Prot : SWS_FT_FI1 147) chain B residue 195 type BINDING sequence N description source Swiss-Prot : SWS_FT_FI1 148) chain B residue 387 type BINDING sequence R description source Swiss-Prot : SWS_FT_FI1 149) chain C residue 39 type BINDING sequence G description source Swiss-Prot : SWS_FT_FI1 150) chain A residue 149 type MOD_RES sequence S description Phosphoserine => ECO:0000250|UniProtKB:P13221 source Swiss-Prot : SWS_FT_FI2 151) chain B residue 149 type MOD_RES sequence S description Phosphoserine => ECO:0000250|UniProtKB:P13221 source Swiss-Prot : SWS_FT_FI2 152) chain C residue 149 type MOD_RES sequence S description Phosphoserine => ECO:0000250|UniProtKB:P13221 source Swiss-Prot : SWS_FT_FI2 153) chain D residue 149 type MOD_RES sequence S description Phosphoserine => ECO:0000250|UniProtKB:P13221 source Swiss-Prot : SWS_FT_FI2 154) chain A residue 259 type MOD_RES sequence K description N6-(pyridoxal phosphate)lysine => ECO:0000250 source Swiss-Prot : SWS_FT_FI3 155) chain B residue 259 type MOD_RES sequence K description N6-(pyridoxal phosphate)lysine => ECO:0000250 source Swiss-Prot : SWS_FT_FI3 156) chain C residue 259 type MOD_RES sequence K description N6-(pyridoxal phosphate)lysine => ECO:0000250 source Swiss-Prot : SWS_FT_FI3 157) chain D residue 259 type MOD_RES sequence K description N6-(pyridoxal phosphate)lysine => ECO:0000250 source Swiss-Prot : SWS_FT_FI3 158) chain A residue 256-269 type prosite sequence SFSKNFGLYNERVG description AA_TRANSFER_CLASS_1 Aminotransferases class-I pyridoxal-phosphate attachment site. SFSKnfGLyNERVG source prosite : PS00105

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