eF-site ID 3ii0-A PDB Code 3ii0 Chain A click to enlarge Title Crystal structure of human Glutamate oxaloacetate transaminase 1 (GOT1) Classification TRANSFERASE Compound Aspartate aminotransferase, cytoplasmic Source Homo sapiens (Human) (AATC_HUMAN) Sequence A:  PVLVFKLTADFREDPDPRKVNLGVGAYRTDDCHPWVLPVV KKVEQKIANDNSLNHEYLPILGLAEFRSCASRLALGDDSP ALKEKRVGGVQSLGGTGALRIGADFLARWYNGTNNKNTPV YVSSPTWENHNAVFSAAGFKDIRSYRYWDAEKRGLDLQGF LNDLENAPEFSIVVLHACAHNPTGIDPTPEQWKQIASVMK HRFLFPFFDSAYQGFASGNLERDAWAIRYFVSEGFEFFCA QSFSKNFGLYNERVGNLTVVGKEPESILQVLSQMEKIVRI TWSNPPAQGARIVASTLSNPELFEEWTGNVKTMADRILTM RSELRARLEALKTPGTWNHITDQIGMFSFTGLNPKQVEYL VNEKHIYLLPSGRINVSGLTTKNLDYVATSIHEAVTKIAE NLYFQ Description Functional site 1) chain A residue 108 type sequence G description BINDING SITE FOR RESIDUE PLP A 1 source : AC1 2) chain A residue 109 type sequence G description BINDING SITE FOR RESIDUE PLP A 1 source : AC1 3) chain A residue 110 type sequence T description BINDING SITE FOR RESIDUE PLP A 1 source : AC1 4) chain A residue 141 type sequence W description BINDING SITE FOR RESIDUE PLP A 1 source : AC1 5) chain A residue 195 type sequence N description BINDING SITE FOR RESIDUE PLP A 1 source : AC1 6) chain A residue 223 type sequence D description BINDING SITE FOR RESIDUE PLP A 1 source : AC1 7) chain A residue 225 type sequence A description BINDING SITE FOR RESIDUE PLP A 1 source : AC1 8) chain A residue 226 type sequence Y description BINDING SITE FOR RESIDUE PLP A 1 source : AC1 9) chain A residue 256 type sequence S description BINDING SITE FOR RESIDUE PLP A 1 source : AC1 10) chain A residue 258 type sequence S description BINDING SITE FOR RESIDUE PLP A 1 source : AC1 11) chain A residue 259 type sequence K description BINDING SITE FOR RESIDUE PLP A 1 source : AC1 12) chain A residue 267 type sequence R description BINDING SITE FOR RESIDUE PLP A 1 source : AC1 13) chain A residue 18 type sequence V description BINDING SITE FOR RESIDUE TAR A 435 source : AC2 14) chain A residue 19 type sequence F description BINDING SITE FOR RESIDUE TAR A 435 source : AC2 15) chain A residue 38 type sequence V description BINDING SITE FOR RESIDUE TAR A 435 source : AC2 16) chain A residue 39 type sequence G description BINDING SITE FOR RESIDUE TAR A 435 source : AC2 17) chain A residue 141 type sequence W description BINDING SITE FOR RESIDUE TAR A 435 source : AC2 18) chain A residue 195 type sequence N description BINDING SITE FOR RESIDUE TAR A 435 source : AC2 19) chain A residue 226 type sequence Y description BINDING SITE FOR RESIDUE TAR A 435 source : AC2 20) chain A residue 259 type sequence K description BINDING SITE FOR RESIDUE TAR A 435 source : AC2 21) chain A residue 361 type sequence F description BINDING SITE FOR RESIDUE TAR A 435 source : AC2 22) chain A residue 387 type sequence R description BINDING SITE FOR RESIDUE TAR A 435 source : AC2 23) chain A residue 128 type sequence N description BINDING SITE FOR RESIDUE EDO A 3 source : AC3 24) chain A residue 130 type sequence K description BINDING SITE FOR RESIDUE EDO A 3 source : AC3 25) chain A residue 41 type sequence Y description BINDING SITE FOR RESIDUE EDO A 11 source : AC4 26) chain A residue 43 type sequence T description BINDING SITE FOR RESIDUE EDO A 11 source : AC4 27) chain A residue 49 type sequence W description BINDING SITE FOR RESIDUE EDO A 11 source : AC4 28) chain A residue 78 type sequence A description BINDING SITE FOR RESIDUE EDO A 436 source : AC5 29) chain A residue 81 type sequence R description BINDING SITE FOR RESIDUE EDO A 436 source : AC5 30) chain A residue 82 type sequence S description BINDING SITE FOR RESIDUE EDO A 436 source : AC5 31) chain A residue 85 type sequence S description BINDING SITE FOR RESIDUE EDO A 436 source : AC5 32) chain A residue 102 type sequence G description BINDING SITE FOR RESIDUE EDO A 436 source : AC5 33) chain A residue 103 type sequence G description BINDING SITE FOR RESIDUE EDO A 436 source : AC5 34) chain A residue 416 type sequence L description BINDING SITE FOR RESIDUE EDO C 5 source : BC4 35) chain A residue 71 type sequence Y description BINDING SITE FOR RESIDUE PLP D 4 source : BC8 36) chain A residue 71 type sequence Y description BINDING SITE FOR RESIDUE TAR D 435 source : BC9 37) chain A residue 293 type sequence R description BINDING SITE FOR RESIDUE TAR D 435 source : BC9 38) chain A residue 39 type BINDING sequence G description source Swiss-Prot : SWS_FT_FI1 39) chain A residue 141 type BINDING sequence W description source Swiss-Prot : SWS_FT_FI1 40) chain A residue 195 type BINDING sequence N description source Swiss-Prot : SWS_FT_FI1 41) chain A residue 387 type BINDING sequence R description source Swiss-Prot : SWS_FT_FI1 42) chain A residue 149 type MOD_RES sequence S description Phosphoserine => ECO:0000250|UniProtKB:P13221 source Swiss-Prot : SWS_FT_FI2 43) chain A residue 259 type MOD_RES sequence K description N6-(pyridoxal phosphate)lysine => ECO:0000250 source Swiss-Prot : SWS_FT_FI3 44) chain A residue 256-269 type prosite sequence SFSKNFGLYNERVG description AA_TRANSFER_CLASS_1 Aminotransferases class-I pyridoxal-phosphate attachment site. SFSKnfGLyNERVG source prosite : PS00105

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