eF-site ID 3ihp-B PDB Code 3ihp Chain B click to enlarge Title Covalent Ubiquitin-Usp5 Complex Classification HYDROLASE Compound Ubiquitin carboxyl-terminal hydrolase 5 Source Homo sapiens (Human) (UBIQ_HUMAN) Sequence B:  MAELSEEALLSVLPTIRVPKAGDRVHKDECAFSFDTPESE GGLYICMNTFLGFGKQYVERHFNKTGQRVYLHLRRTDEDV KIVILPDYLEIARDGLGGLPDIVRDRVTSAVEALLSVRQV SKHAFSLKQLDNPARIPPCGWKCSKCDMRENLWLNLTDGS ILCGRRYFDGSGGNNHAVEHYRETGYPLAVKLGTITPDGA DVYSYDEDDMVLDPSLAEHLSHFGIDMPLKPLFGPGYTGI RNLGNSCYLNSVVQVLFSIPDFQRKYVDKLEKIFQNAPTD PTQDFSTQVAKLGHGLLSGEGIAPRMFKALIGKGHPEFST NRQQDAQEFFLHLINMVERNCRSSENPNEVFRFLVEEKIK CLATEKVKYTQRVDYIMQLPVPMDAALNKEELLEYEEKKR QAEEEKMALPELVRAQVPFSSCLEAYGAPEQVDDFWSTAL QAKSVAVKTTRFASFPDYLVIQIKKFTFGLDWVPKKLDVS IEMPEELDISQLRGTGLQPGEEELPDILDESVIIQLVEMG FPMDACRKAVYYTGNSGAEAAMNWVMSHMDDPDFANPLIL DPPPEDCVTTIVSMGFSRDQALKALRATNNSLERAVDWIF SHIDDLDAEAAMDGPKVRDGPGKYQLFAFISHMGTSTMCG HYVCHIKKEGRWVIYNDQKVCASEKPPKDLGYIYFYQRVA S Description Functional site 1) chain B residue 333 type sequence N description BINDING SITE FOR RESIDUE NEH D 76 source : AC2 2) chain B residue 335 type sequence C description BINDING SITE FOR RESIDUE NEH D 76 source : AC2 3) chain B residue 433 type sequence Q description BINDING SITE FOR RESIDUE NEH D 76 source : AC2 4) chain B residue 794 type sequence G description BINDING SITE FOR RESIDUE NEH D 76 source : AC2 5) chain B residue 199 type sequence C description BINDING SITE FOR RESIDUE ZN B 836 source : AC5 6) chain B residue 202 type sequence C description BINDING SITE FOR RESIDUE ZN B 836 source : AC5 7) chain B residue 219 type sequence C description BINDING SITE FOR RESIDUE ZN B 836 source : AC5 8) chain B residue 232 type sequence H description BINDING SITE FOR RESIDUE ZN B 836 source : AC5 9) chain B residue 175-283 type ZN_FING sequence QVSKHAFSLKQLDNPARIPPCGWKCSKCDMRENLWLNLTD GSILCGRRYFDGSGGNNHAVEHYRETGYPLAVKLGTITPD GADVYSYDEDDMVLDPSLAEHLSHFGIDM description UBP-type; degenerate => ECO:0000255|PROSITE-ProRule:PRU00502 source Swiss-Prot : SWS_FT_FI1 10) chain B residue 779 type MOD_RES sequence Q description Phosphoserine => ECO:0007744|PubMed:23186163 source Swiss-Prot : SWS_FT_FI10 11) chain B residue 785 type MOD_RES sequence S description Phosphoserine => ECO:0007744|PubMed:23186163 source Swiss-Prot : SWS_FT_FI10 12) chain B residue 783 type MOD_RES sequence F description Phosphoserine => ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163 source Swiss-Prot : SWS_FT_FI11 13) chain B residue 335 type ACT_SITE sequence C description Nucleophile source Swiss-Prot : SWS_FT_FI2 14) chain B residue 818 type ACT_SITE sequence E description Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU10092, ECO:0000255|PROSITE-ProRule:PRU10093 source Swiss-Prot : SWS_FT_FI3 15) chain B residue 199 type BINDING sequence C description BINDING => ECO:0000255|PROSITE-ProRule:PRU00502 source Swiss-Prot : SWS_FT_FI4 16) chain B residue 202 type BINDING sequence C description BINDING => ECO:0000255|PROSITE-ProRule:PRU00502 source Swiss-Prot : SWS_FT_FI4 17) chain B residue 219 type BINDING sequence C description BINDING => ECO:0000255|PROSITE-ProRule:PRU00502 source Swiss-Prot : SWS_FT_FI4 18) chain B residue 232 type BINDING sequence H description BINDING => ECO:0000255|PROSITE-ProRule:PRU00502 source Swiss-Prot : SWS_FT_FI4 19) chain B residue 264 type BINDING sequence D description source Swiss-Prot : SWS_FT_FI5 20) chain B residue 209 type BINDING sequence W description source Swiss-Prot : SWS_FT_FI5 21) chain B residue 221 type BINDING sequence R description source Swiss-Prot : SWS_FT_FI5 22) chain B residue 259 type BINDING sequence Y description source Swiss-Prot : SWS_FT_FI5 23) chain B residue 261 type BINDING sequence Y description source Swiss-Prot : SWS_FT_FI5 24) chain B residue 2 type MOD_RES sequence A description N-acetylalanine => ECO:0007744|PubMed:19413330, ECO:0007744|PubMed:22223895, ECO:0007744|PubMed:22814378 source Swiss-Prot : SWS_FT_FI6 25) chain B residue 156 type MOD_RES sequence S description Phosphoserine => ECO:0007744|PubMed:24275569 source Swiss-Prot : SWS_FT_FI7

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