eF-site ID 3i8p-A PDB Code 3i8p Chain A click to enlarge Title Crystal structure of E. coli FabF(C163A) in complex with Platensimycin A1 Classification TRANSFERASE Compound 3-oxoacyl-[acyl-carrier-protein] synthase 2 Source Escherichia coli (strain K12) (FABF_ECOLI) Sequence A:  KRRVVVTGLGMLSPVGNTVESTWKALLAGQSGISLIDHFD TSAYATKFAGLVKDFNCEDIISRKEQRKMDAFIQYGIVAG VQAMQDSGLEITEENATRIGAAIGSGIGGLGLIEENHTSL MNGGPRKISPFFVPSTIVNMVAGHLTIMYGLRGPSISIAT AATSGVHNIGHAARIIAYGDADVMVAGGAEKASTPLGVGG FGAARALSTRNDNPQAASRPWDKERDGFVLGDGAGMLVLE EYEHAKKRGAKIYAELVGFGMSSDAYHMTSPPENGAGAAL AMANALRDAGIEASQIGYVNAHGTSTPAGDKAEAQAVKTI FGEAASRVLVSSTKSMTGHLLGAAGAVESIYSILALRDQA VPPTINLDNPDEGCDLDFVPHEARQVSGMEYTLCNSFGFG GTNGSLIFKKI Description Functional site 1) chain A residue 163 type sequence A description BINDING SITE FOR RESIDUE 840 A 501 source : AC1 2) chain A residue 205 type sequence A description BINDING SITE FOR RESIDUE 840 A 501 source : AC1 3) chain A residue 206 type sequence R description BINDING SITE FOR RESIDUE 840 A 501 source : AC1 4) chain A residue 270 type sequence T description BINDING SITE FOR RESIDUE 840 A 501 source : AC1 5) chain A residue 271 type sequence S description BINDING SITE FOR RESIDUE 840 A 501 source : AC1 6) chain A residue 272 type sequence P description BINDING SITE FOR RESIDUE 840 A 501 source : AC1 7) chain A residue 303 type sequence H description BINDING SITE FOR RESIDUE 840 A 501 source : AC1 8) chain A residue 307 type sequence T description BINDING SITE FOR RESIDUE 840 A 501 source : AC1 9) chain A residue 308 type sequence P description BINDING SITE FOR RESIDUE 840 A 501 source : AC1 10) chain A residue 309 type sequence A description BINDING SITE FOR RESIDUE 840 A 501 source : AC1 11) chain A residue 310 type sequence G description BINDING SITE FOR RESIDUE 840 A 501 source : AC1 12) chain A residue 340 type sequence H description BINDING SITE FOR RESIDUE 840 A 501 source : AC1 13) chain A residue 398 type sequence F description BINDING SITE FOR RESIDUE 840 A 501 source : AC1 14) chain A residue 399 type sequence G description BINDING SITE FOR RESIDUE 840 A 501 source : AC1 15) chain A residue 400 type sequence F description BINDING SITE FOR RESIDUE 840 A 501 source : AC1 16) chain A residue 149 type catalytic sequence M description 574 source MCSA : MCSA1 17) chain A residue 289 type catalytic sequence D description 574 source MCSA : MCSA1 18) chain A residue 300 type catalytic sequence V description 574 source MCSA : MCSA1 19) chain A residue 321 type catalytic sequence I description 574 source MCSA : MCSA1 20) chain A residue 326 type catalytic sequence A description 574 source MCSA : MCSA1 21) chain A residue 386 type catalytic sequence Q description 574 source MCSA : MCSA1 22) chain A residue 289 type BINDING sequence D description BINDING => ECO:0000269|PubMed:16710421, ECO:0000269|PubMed:19233644, ECO:0007744|PDB:2GFX, ECO:0007744|PDB:3G0Y, ECO:0007744|PDB:3G11 source Swiss-Prot : SWS_FT_FI4 23) chain A residue 326 type BINDING sequence A description BINDING => ECO:0000269|PubMed:16710421, ECO:0000269|PubMed:19233644, ECO:0007744|PDB:2GFX, ECO:0007744|PDB:3G0Y, ECO:0007744|PDB:3G11 source Swiss-Prot : SWS_FT_FI4 24) chain A residue 149 type ACT_SITE sequence M description For beta-ketoacyl synthase activity => ECO:0000255|PROSITE-ProRule:PRU01348, ECO:0000269|PubMed:10037680, ECO:0000305|PubMed:9482715 source Swiss-Prot : SWS_FT_FI1 25) chain A residue 289 type ACT_SITE sequence D description For beta-ketoacyl synthase activity => ECO:0000255|PROSITE-ProRule:PRU01348 source Swiss-Prot : SWS_FT_FI2 26) chain A residue 326 type ACT_SITE sequence A description For beta-ketoacyl synthase activity => ECO:0000255|PROSITE-ProRule:PRU01348 source Swiss-Prot : SWS_FT_FI2 27) chain A residue 256 type BINDING sequence E description BINDING => ECO:0000269|PubMed:16710421, ECO:0000269|PubMed:19233644, ECO:0000269|PubMed:19581087, ECO:0007744|PDB:2GFX, ECO:0007744|PDB:3G0Y, ECO:0007744|PDB:3G11, ECO:0007744|PDB:3HNZ, ECO:0007744|PDB:3I8P source Swiss-Prot : SWS_FT_FI3 28) chain A residue 293 type BINDING sequence E description BINDING => ECO:0000269|PubMed:16710421, ECO:0000269|PubMed:19233644, ECO:0000269|PubMed:19581087, ECO:0007744|PDB:2GFX, ECO:0007744|PDB:3G0Y, ECO:0007744|PDB:3G11, ECO:0007744|PDB:3HNZ, ECO:0007744|PDB:3I8P source Swiss-Prot : SWS_FT_FI3

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