eF-site/Summary 3i3t-E

eF-site ID	3i3t-E
PDB Code	3i3t
Chain	E

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Title	Crystal structure of covalent ubiquitin-USP21 complex
Classification	HYDROLASE
Compound	Ubiquitin carboxyl-terminal hydrolase 21
Source	Homo sapiens (Human) (UBIQ_HUMAN)

Sequence	E:	HVGLRNLGNTCFLNAVLQCLSSTRPLRDFCLRRDFRQEVQ ELTEAFADVIGALWHPDSCEAVNPTRFRAVFQKYVPSFSG YSQQDAQEFLKLLMERLHLEINRRLSDDDRANLMWKRYLE REDSKIVDLFVGQLKSCLKCQACGYRSTTFEVFCDLSLPI PKKGFAGGKVSLRDCFNLFTKEEELESENAPVCDRCRQKT RSTKKLTVQRFPRILVLHLNRFSASRGSIKKSSVGVDFPL QRLSLGDFASSPVYQLYALCNHSGSVHYGHYTALCRCQTG WHVYNDSRVSPVSENQVASSEGYVLFYQLM

Description

Functional site


1)	chain	E
	residue	384
	type
	sequence	C
	description	BINDING SITE FOR RESIDUE ZN E 700
	source	: AC3

2)	chain	E
	residue	387
	type
	sequence	C
	description	BINDING SITE FOR RESIDUE ZN E 700
	source	: AC3

3)	chain	E
	residue	437
	type
	sequence	C
	description	BINDING SITE FOR RESIDUE ZN E 700
	source	: AC3

4)	chain	E
	residue	440
	type
	sequence	C
	description	BINDING SITE FOR RESIDUE ZN E 700
	source	: AC3

5)	chain	E
	residue	219
	type
	sequence	N
	description	BINDING SITE FOR RESIDUE NEH F 76
	source	: AC7

6)	chain	E
	residue	221
	type
	sequence	C
	description	BINDING SITE FOR RESIDUE NEH F 76
	source	: AC7

7)	chain	E
	residue	299
	type
	sequence	Q
	description	BINDING SITE FOR RESIDUE NEH F 76
	source	: AC7

8)	chain	E
	residue	517
	type
	sequence	G
	description	BINDING SITE FOR RESIDUE NEH F 76
	source	: AC7

9)	chain	E
	residue	387
	type	MOD_RES
	sequence	C
	description	Phosphoserine; by PINK1 => ECO:0000269\|PubMed:24660806, ECO:0000269\|PubMed:24751536, ECO:0000269\|PubMed:24784582, ECO:0000269\|PubMed:25474007, ECO:0000269\|PubMed:25527291
	source	Swiss-Prot : SWS_FT_FI3

10)	chain	E
	residue	437
	type	MOD_RES
	sequence	C
	description	Phosphoserine; by PINK1 => ECO:0000269\|PubMed:24660806, ECO:0000269\|PubMed:24751536, ECO:0000269\|PubMed:24784582, ECO:0000269\|PubMed:25474007, ECO:0000269\|PubMed:25527291
	source	Swiss-Prot : SWS_FT_FI3

11)	chain	E
	residue	440
	type	MOD_RES
	sequence	C
	description	Phosphoserine; by PINK1 => ECO:0000269\|PubMed:24660806, ECO:0000269\|PubMed:24751536, ECO:0000269\|PubMed:24784582, ECO:0000269\|PubMed:25474007, ECO:0000269\|PubMed:25527291
	source	Swiss-Prot : SWS_FT_FI3

12)	chain	E
	residue	384
	type	MOD_RES
	sequence	C
	description	Phosphoserine; by PINK1 => ECO:0000269\|PubMed:24660806, ECO:0000269\|PubMed:24751536, ECO:0000269\|PubMed:24784582, ECO:0000269\|PubMed:25474007, ECO:0000269\|PubMed:25527291
	source	Swiss-Prot : SWS_FT_FI3