eF-site ID 3hy7-B PDB Code 3hy7 Chain B click to enlarge Title Crystal Structure of the Catalytic Domain of ADAMTS-5 in Complex with Marimastat Classification HYDROLASE Compound A disintegrin and metalloproteinase with thrombospondin motifs 5 Source Homo sapiens (Human) (ATS5_HUMAN) Sequence B:  SRARQVELLLVADASMARKYGRGLQHYLLTLASIANRLYS HASIENHIRLAVVKVVVLGDKDKSLEVSKNAATTLKNFCK WQHQHNQLGDDHEEHYDAAILFTREDLCGHHSCDTLGMAD VGTICSPERSCAVIEDDGLHAAFTVAHEIGHLLGLSHDDS KFCEETFGSTEDKRLMSSILTSIDASKPWSKCTSATITEF LDDGHGNCLLDLPRKQI Description Functional site 1) chain B residue 377 type sequence D description BINDING SITE FOR RESIDUE 097 B 801 source : AC6 2) chain B residue 378 type sequence T description BINDING SITE FOR RESIDUE 097 B 801 source : AC6 3) chain B residue 379 type sequence L description BINDING SITE FOR RESIDUE 097 B 801 source : AC6 4) chain B residue 380 type sequence G description BINDING SITE FOR RESIDUE 097 B 801 source : AC6 5) chain B residue 410 type sequence H description BINDING SITE FOR RESIDUE 097 B 801 source : AC6 6) chain B residue 411 type sequence E description BINDING SITE FOR RESIDUE 097 B 801 source : AC6 7) chain B residue 414 type sequence H description BINDING SITE FOR RESIDUE 097 B 801 source : AC6 8) chain B residue 420 type sequence H description BINDING SITE FOR RESIDUE 097 B 801 source : AC6 9) chain B residue 440 type sequence S description BINDING SITE FOR RESIDUE 097 B 801 source : AC6 10) chain B residue 441 type sequence S description BINDING SITE FOR RESIDUE 097 B 801 source : AC6 11) chain B residue 442 type sequence I description BINDING SITE FOR RESIDUE 097 B 801 source : AC6 12) chain B residue 443 type sequence L description BINDING SITE FOR RESIDUE 097 B 801 source : AC6 13) chain B residue 410 type sequence H description BINDING SITE FOR RESIDUE ZN B 901 source : AC7 14) chain B residue 414 type sequence H description BINDING SITE FOR RESIDUE ZN B 901 source : AC7 15) chain B residue 420 type sequence H description BINDING SITE FOR RESIDUE ZN B 901 source : AC7 16) chain B residue 270 type sequence E description BINDING SITE FOR RESIDUE CA B 902 source : AC8 17) chain B residue 353 type sequence D description BINDING SITE FOR RESIDUE CA B 902 source : AC8 18) chain B residue 360 type sequence D description BINDING SITE FOR RESIDUE CA B 902 source : AC8 19) chain B residue 471 type sequence C description BINDING SITE FOR RESIDUE CA B 902 source : AC8 20) chain B residue 474 type sequence D description BINDING SITE FOR RESIDUE CA B 902 source : AC8 21) chain B residue 270 type sequence E description BINDING SITE FOR RESIDUE CA B 903 source : AC9 22) chain B residue 353 type sequence D description BINDING SITE FOR RESIDUE CA B 903 source : AC9 23) chain B residue 474 type sequence D description BINDING SITE FOR RESIDUE CA B 903 source : AC9 24) chain B residue 369 type sequence D description BINDING SITE FOR RESIDUE CA B 904 source : BC1 25) chain B residue 370 type sequence L description BINDING SITE FOR RESIDUE CA B 904 source : BC1 26) chain B residue 376 type sequence C description BINDING SITE FOR RESIDUE CA B 904 source : BC1 27) chain B residue 378 type sequence T description BINDING SITE FOR RESIDUE CA B 904 source : BC1 28) chain B residue 398 type sequence E description BINDING SITE FOR RESIDUE CA B 904 source : BC1 29) chain B residue 411 type ACT_SITE sequence E description ACT_SITE => ECO:0000255|PROSITE-ProRule:PRU00276, ECO:0000255|PROSITE-ProRule:PRU10095, ECO:0000269|PubMed:18042673 source Swiss-Prot : SWS_FT_FI1 30) chain B residue 410 type BINDING sequence H description BINDING => ECO:0000269|PubMed:18042673 source Swiss-Prot : SWS_FT_FI2 31) chain B residue 414 type BINDING sequence H description BINDING => ECO:0000269|PubMed:18042673 source Swiss-Prot : SWS_FT_FI2 32) chain B residue 420 type BINDING sequence H description BINDING => ECO:0000269|PubMed:18042673 source Swiss-Prot : SWS_FT_FI2

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