eF-site ID 3hy7-AB PDB Code 3hy7 Chain A, B click to enlarge Title Crystal Structure of the Catalytic Domain of ADAMTS-5 in Complex with Marimastat Classification HYDROLASE Compound A disintegrin and metalloproteinase with thrombospondin motifs 5 Source Homo sapiens (Human) (ATS5_HUMAN) Sequence A:  SRARQVELLLVADASMARKYGRGLQHYLLTLASIANRLYS HASIENHIRLAVVKVVVLGDKDKSLEVSKNAATTLKNFCK WQHQHNQLGDDHEEHYDAAILFTREDLCGHHSCDTLGMAD VGTICSPERSCAVIEDDGLHAAFTVAHEIGHLLGLSHDDS KFCEETFGSTEDKRLMSSILTSIDASKPWSKCTSATITEF LDDGHGNCLLDLPRKQI B:  SRARQVELLLVADASMARKYGRGLQHYLLTLASIANRLYS HASIENHIRLAVVKVVVLGDKDKSLEVSKNAATTLKNFCK WQHQHNQLGDDHEEHYDAAILFTREDLCGHHSCDTLGMAD VGTICSPERSCAVIEDDGLHAAFTVAHEIGHLLGLSHDDS KFCEETFGSTEDKRLMSSILTSIDASKPWSKCTSATITEF LDDGHGNCLLDLPRKQI Description Functional site 1) chain A residue 377 type sequence D description BINDING SITE FOR RESIDUE 097 A 801 source : AC1 2) chain A residue 378 type sequence T description BINDING SITE FOR RESIDUE 097 A 801 source : AC1 3) chain A residue 379 type sequence L description BINDING SITE FOR RESIDUE 097 A 801 source : AC1 4) chain A residue 380 type sequence G description BINDING SITE FOR RESIDUE 097 A 801 source : AC1 5) chain A residue 410 type sequence H description BINDING SITE FOR RESIDUE 097 A 801 source : AC1 6) chain A residue 411 type sequence E description BINDING SITE FOR RESIDUE 097 A 801 source : AC1 7) chain A residue 414 type sequence H description BINDING SITE FOR RESIDUE 097 A 801 source : AC1 8) chain A residue 420 type sequence H description BINDING SITE FOR RESIDUE 097 A 801 source : AC1 9) chain A residue 440 type sequence S description BINDING SITE FOR RESIDUE 097 A 801 source : AC1 10) chain A residue 441 type sequence S description BINDING SITE FOR RESIDUE 097 A 801 source : AC1 11) chain A residue 442 type sequence I description BINDING SITE FOR RESIDUE 097 A 801 source : AC1 12) chain A residue 443 type sequence L description BINDING SITE FOR RESIDUE 097 A 801 source : AC1 13) chain A residue 410 type sequence H description BINDING SITE FOR RESIDUE ZN A 901 source : AC2 14) chain A residue 414 type sequence H description BINDING SITE FOR RESIDUE ZN A 901 source : AC2 15) chain A residue 420 type sequence H description BINDING SITE FOR RESIDUE ZN A 901 source : AC2 16) chain A residue 270 type sequence E description BINDING SITE FOR RESIDUE CA A 902 source : AC3 17) chain A residue 353 type sequence D description BINDING SITE FOR RESIDUE CA A 902 source : AC3 18) chain A residue 360 type sequence D description BINDING SITE FOR RESIDUE CA A 902 source : AC3 19) chain A residue 471 type sequence C description BINDING SITE FOR RESIDUE CA A 902 source : AC3 20) chain A residue 474 type sequence D description BINDING SITE FOR RESIDUE CA A 902 source : AC3 21) chain A residue 270 type sequence E description BINDING SITE FOR RESIDUE CA A 903 source : AC4 22) chain A residue 353 type sequence D description BINDING SITE FOR RESIDUE CA A 903 source : AC4 23) chain A residue 474 type sequence D description BINDING SITE FOR RESIDUE CA A 903 source : AC4 24) chain A residue 369 type sequence D description BINDING SITE FOR RESIDUE CA A 904 source : AC5 25) chain A residue 370 type sequence L description BINDING SITE FOR RESIDUE CA A 904 source : AC5 26) chain A residue 376 type sequence C description BINDING SITE FOR RESIDUE CA A 904 source : AC5 27) chain A residue 378 type sequence T description BINDING SITE FOR RESIDUE CA A 904 source : AC5 28) chain A residue 398 type sequence E description BINDING SITE FOR RESIDUE CA A 904 source : AC5 29) chain B residue 377 type sequence D description BINDING SITE FOR RESIDUE 097 B 801 source : AC6 30) chain B residue 378 type sequence T description BINDING SITE FOR RESIDUE 097 B 801 source : AC6 31) chain B residue 379 type sequence L description BINDING SITE FOR RESIDUE 097 B 801 source : AC6 32) chain B residue 380 type sequence G description BINDING SITE FOR RESIDUE 097 B 801 source : AC6 33) chain B residue 410 type sequence H description BINDING SITE FOR RESIDUE 097 B 801 source : AC6 34) chain B residue 411 type sequence E description BINDING SITE FOR RESIDUE 097 B 801 source : AC6 35) chain B residue 414 type sequence H description BINDING SITE FOR RESIDUE 097 B 801 source : AC6 36) chain B residue 420 type sequence H description BINDING SITE FOR RESIDUE 097 B 801 source : AC6 37) chain B residue 440 type sequence S description BINDING SITE FOR RESIDUE 097 B 801 source : AC6 38) chain B residue 441 type sequence S description BINDING SITE FOR RESIDUE 097 B 801 source : AC6 39) chain B residue 442 type sequence I description BINDING SITE FOR RESIDUE 097 B 801 source : AC6 40) chain B residue 443 type sequence L description BINDING SITE FOR RESIDUE 097 B 801 source : AC6 41) chain B residue 410 type sequence H description BINDING SITE FOR RESIDUE ZN B 901 source : AC7 42) chain B residue 414 type sequence H description BINDING SITE FOR RESIDUE ZN B 901 source : AC7 43) chain B residue 420 type sequence H description BINDING SITE FOR RESIDUE ZN B 901 source : AC7 44) chain B residue 270 type sequence E description BINDING SITE FOR RESIDUE CA B 902 source : AC8 45) chain B residue 353 type sequence D description BINDING SITE FOR RESIDUE CA B 902 source : AC8 46) chain B residue 360 type sequence D description BINDING SITE FOR RESIDUE CA B 902 source : AC8 47) chain B residue 471 type sequence C description BINDING SITE FOR RESIDUE CA B 902 source : AC8 48) chain B residue 474 type sequence D description BINDING SITE FOR RESIDUE CA B 902 source : AC8 49) chain B residue 270 type sequence E description BINDING SITE FOR RESIDUE CA B 903 source : AC9 50) chain B residue 353 type sequence D description BINDING SITE FOR RESIDUE CA B 903 source : AC9 51) chain B residue 474 type sequence D description BINDING SITE FOR RESIDUE CA B 903 source : AC9 52) chain B residue 369 type sequence D description BINDING SITE FOR RESIDUE CA B 904 source : BC1 53) chain B residue 370 type sequence L description BINDING SITE FOR RESIDUE CA B 904 source : BC1 54) chain B residue 376 type sequence C description BINDING SITE FOR RESIDUE CA B 904 source : BC1 55) chain B residue 378 type sequence T description BINDING SITE FOR RESIDUE CA B 904 source : BC1 56) chain B residue 398 type sequence E description BINDING SITE FOR RESIDUE CA B 904 source : BC1 57) chain A residue 411 type ACT_SITE sequence E description ACT_SITE => ECO:0000255|PROSITE-ProRule:PRU00276, ECO:0000255|PROSITE-ProRule:PRU10095, ECO:0000269|PubMed:18042673 source Swiss-Prot : SWS_FT_FI1 58) chain B residue 411 type ACT_SITE sequence E description ACT_SITE => ECO:0000255|PROSITE-ProRule:PRU00276, ECO:0000255|PROSITE-ProRule:PRU10095, ECO:0000269|PubMed:18042673 source Swiss-Prot : SWS_FT_FI1 59) chain A residue 410 type BINDING sequence H description BINDING => ECO:0000269|PubMed:18042673 source Swiss-Prot : SWS_FT_FI2 60) chain A residue 414 type BINDING sequence H description BINDING => ECO:0000269|PubMed:18042673 source Swiss-Prot : SWS_FT_FI2 61) chain A residue 420 type BINDING sequence H description BINDING => ECO:0000269|PubMed:18042673 source Swiss-Prot : SWS_FT_FI2 62) chain B residue 410 type BINDING sequence H description BINDING => ECO:0000269|PubMed:18042673 source Swiss-Prot : SWS_FT_FI2 63) chain B residue 414 type BINDING sequence H description BINDING => ECO:0000269|PubMed:18042673 source Swiss-Prot : SWS_FT_FI2 64) chain B residue 420 type BINDING sequence H description BINDING => ECO:0000269|PubMed:18042673 source Swiss-Prot : SWS_FT_FI2 65) chain A residue 407-416 type prosite sequence TVAHEIGHLL description ZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. TVAHEIGHLL source prosite : PS00142

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