eF-site ID 3hsp-AB PDB Code 3hsp Chain A, B click to enlarge Title Ternary structure of neuronal nitric oxide synthase with NHA and NO bound(2) Classification OXIDOREDUCTASE Compound Nitric oxide synthase, brain Source (NOS1_RAT) Sequence A:  RFLKVKNWETDVVLTDTLHLKSTLETGCTEHICMGSIMLP SVRTKDQLFPLAKEFLDQYYSSIKRFGSKAHMDRLEEVNK EIESTSTYQLKDTELIYGAKHAWRNASRCVGRIQWSKLQV FDARDCTTAHGMFNYICNHVKYATNKGNLRSAITIFPQRT DGKHDFRVWNSQLIRYAGYKQPDGSTLGDPANVQFTEICI QQGWKAPRGRFDVLPLLLQANGNDPELFQIPPELVLEVPI RHPKFDWFKDLGLKWYGLPAVSNMLLEIGGLEFSACPFSG WYMGTEIGVRDYCDNSRYNILEEVAKKMDLDMRKTSSLWK DQALVEINIAVLYSFQSDKVTIVDHHSATESFIKHMENEY RCRGGCPADWVWIVPPMSGSITPVFHQEMLNYRLTPSFEY QPDPWNTHVWKG B:  PRFLKVKNWETDVVLTDTLHLKSTLETGCTEHICMGSIML PSVRTKDQLFPLAKEFLDQYYSSIKRFGSKAHMDRLEEVN KEIESTSTYQLKDTELIYGAKHAWRNASRCVGRIQWSKLQ VFDARDCTTAHGMFNYICNHVKYATNKGNLRSAITIFPQR TDGKHDFRVWNSQLIRYAGYKQPDGSTLGDPANVQFTEIC IQQGWKAPRGRFDVLPLLLQANGNDPELFQIPPELVLEVP IRHPKFDWFKDLGLKWYGLPAVSNMLLEIGGLEFSACPFS GWYMGTEIGVRDYCDNSRYNILEEVAKKMDLDMRKTSSLW KDQALVEINIAVLYSFQSDKVTIVDHHSATESFIKHMENE YRCRGGCPADWVWIVPPMSGSITPVFHQEMLNYRLTPSFE YQPDPWNTHVWKG Description Functional site 1) chain A residue 409 type sequence W description BINDING SITE FOR RESIDUE HEM A 750 source : AC1 2) chain A residue 414 type sequence R description BINDING SITE FOR RESIDUE HEM A 750 source : AC1 3) chain A residue 415 type sequence C description BINDING SITE FOR RESIDUE HEM A 750 source : AC1 4) chain A residue 416 type sequence V description BINDING SITE FOR RESIDUE HEM A 750 source : AC1 5) chain A residue 417 type sequence G description BINDING SITE FOR RESIDUE HEM A 750 source : AC1 6) chain A residue 457 type sequence S description BINDING SITE FOR RESIDUE HEM A 750 source : AC1 7) chain A residue 584 type sequence F description BINDING SITE FOR RESIDUE HEM A 750 source : AC1 8) chain A residue 585 type sequence S description BINDING SITE FOR RESIDUE HEM A 750 source : AC1 9) chain A residue 586 type sequence G description BINDING SITE FOR RESIDUE HEM A 750 source : AC1 10) chain A residue 587 type sequence W description BINDING SITE FOR RESIDUE HEM A 750 source : AC1 11) chain A residue 592 type sequence E description BINDING SITE FOR RESIDUE HEM A 750 source : AC1 12) chain A residue 678 type sequence W description BINDING SITE FOR RESIDUE HEM A 750 source : AC1 13) chain A residue 704 type sequence F description BINDING SITE FOR RESIDUE HEM A 750 source : AC1 14) chain A residue 706 type sequence Y description BINDING SITE FOR RESIDUE HEM A 750 source : AC1 15) chain A residue 584 type sequence F description BINDING SITE FOR RESIDUE NO A 752 source : AC2 16) chain A residue 334 type sequence S description BINDING SITE FOR RESIDUE H4B A 760 source : AC3 17) chain A residue 596 type sequence R description BINDING SITE FOR RESIDUE H4B A 760 source : AC3 18) chain A residue 677 type sequence V description BINDING SITE FOR RESIDUE H4B A 760 source : AC3 19) chain A residue 678 type sequence W description BINDING SITE FOR RESIDUE H4B A 760 source : AC3 20) chain B residue 676 type sequence W description BINDING SITE FOR RESIDUE H4B A 760 source : AC3 21) chain B residue 691 type sequence F description BINDING SITE FOR RESIDUE H4B A 760 source : AC3 22) chain B residue 692 type sequence H description BINDING SITE FOR RESIDUE H4B A 760 source : AC3 23) chain B residue 693 type sequence Q description BINDING SITE FOR RESIDUE H4B A 760 source : AC3 24) chain B residue 694 type sequence E description BINDING SITE FOR RESIDUE H4B A 760 source : AC3 25) chain A residue 478 type sequence Q description BINDING SITE FOR RESIDUE HAR A 770 source : AC4 26) chain A residue 562 type sequence Y description BINDING SITE FOR RESIDUE HAR A 770 source : AC4 27) chain A residue 586 type sequence G description BINDING SITE FOR RESIDUE HAR A 770 source : AC4 28) chain A residue 587 type sequence W description BINDING SITE FOR RESIDUE HAR A 770 source : AC4 29) chain A residue 588 type sequence Y description BINDING SITE FOR RESIDUE HAR A 770 source : AC4 30) chain A residue 592 type sequence E description BINDING SITE FOR RESIDUE HAR A 770 source : AC4 31) chain A residue 597 type sequence D description BINDING SITE FOR RESIDUE HAR A 770 source : AC4 32) chain A residue 587 type sequence W description BINDING SITE FOR RESIDUE ACT A 860 source : AC5 33) chain A residue 649 type sequence V description BINDING SITE FOR RESIDUE ACT A 860 source : AC5 34) chain A residue 657 type sequence S description BINDING SITE FOR RESIDUE ACT A 860 source : AC5 35) chain A residue 326 type sequence C description BINDING SITE FOR RESIDUE ZN A 900 source : AC6 36) chain A residue 331 type sequence C description BINDING SITE FOR RESIDUE ZN A 900 source : AC6 37) chain B residue 326 type sequence C description BINDING SITE FOR RESIDUE ZN A 900 source : AC6 38) chain B residue 331 type sequence C description BINDING SITE FOR RESIDUE ZN A 900 source : AC6 39) chain A residue 364 type sequence Q description BINDING SITE FOR RESIDUE GOL A 880 source : AC7 40) chain A residue 669 type sequence R description BINDING SITE FOR RESIDUE GOL A 880 source : AC7 41) chain A residue 406 type sequence K description BINDING SITE FOR RESIDUE GOL A 882 source : AC8 42) chain A residue 424 type sequence L description BINDING SITE FOR RESIDUE GOL A 882 source : AC8 43) chain A residue 425 type sequence Q description BINDING SITE FOR RESIDUE GOL A 882 source : AC8 44) chain A residue 426 type sequence V description BINDING SITE FOR RESIDUE GOL A 882 source : AC8 45) chain B residue 409 type sequence W description BINDING SITE FOR RESIDUE HEM B 750 source : AC9 46) chain B residue 415 type sequence C description BINDING SITE FOR RESIDUE HEM B 750 source : AC9 47) chain B residue 457 type sequence S description BINDING SITE FOR RESIDUE HEM B 750 source : AC9 48) chain B residue 584 type sequence F description BINDING SITE FOR RESIDUE HEM B 750 source : AC9 49) chain B residue 586 type sequence G description BINDING SITE FOR RESIDUE HEM B 750 source : AC9 50) chain B residue 587 type sequence W description BINDING SITE FOR RESIDUE HEM B 750 source : AC9 51) chain B residue 592 type sequence E description BINDING SITE FOR RESIDUE HEM B 750 source : AC9 52) chain B residue 678 type sequence W description BINDING SITE FOR RESIDUE HEM B 750 source : AC9 53) chain B residue 704 type sequence F description BINDING SITE FOR RESIDUE HEM B 750 source : AC9 54) chain B residue 706 type sequence Y description BINDING SITE FOR RESIDUE HEM B 750 source : AC9 55) chain B residue 584 type sequence F description BINDING SITE FOR RESIDUE NO B 752 source : BC1 56) chain A residue 676 type sequence W description BINDING SITE FOR RESIDUE H4B B 1760 source : BC2 57) chain A residue 691 type sequence F description BINDING SITE FOR RESIDUE H4B B 1760 source : BC2 58) chain A residue 692 type sequence H description BINDING SITE FOR RESIDUE H4B B 1760 source : BC2 59) chain A residue 694 type sequence E description BINDING SITE FOR RESIDUE H4B B 1760 source : BC2 60) chain B residue 334 type sequence S description BINDING SITE FOR RESIDUE H4B B 1760 source : BC2 61) chain B residue 596 type sequence R description BINDING SITE FOR RESIDUE H4B B 1760 source : BC2 62) chain B residue 677 type sequence V description BINDING SITE FOR RESIDUE H4B B 1760 source : BC2 63) chain B residue 678 type sequence W description BINDING SITE FOR RESIDUE H4B B 1760 source : BC2 64) chain B residue 478 type sequence Q description BINDING SITE FOR RESIDUE HAR B 1770 source : BC3 65) chain B residue 562 type sequence Y description BINDING SITE FOR RESIDUE HAR B 1770 source : BC3 66) chain B residue 567 type sequence V description BINDING SITE FOR RESIDUE HAR B 1770 source : BC3 67) chain B residue 586 type sequence G description BINDING SITE FOR RESIDUE HAR B 1770 source : BC3 68) chain B residue 587 type sequence W description BINDING SITE FOR RESIDUE HAR B 1770 source : BC3 69) chain B residue 588 type sequence Y description BINDING SITE FOR RESIDUE HAR B 1770 source : BC3 70) chain B residue 592 type sequence E description BINDING SITE FOR RESIDUE HAR B 1770 source : BC3 71) chain B residue 597 type sequence D description BINDING SITE FOR RESIDUE HAR B 1770 source : BC3 72) chain B residue 417 type sequence G description BINDING SITE FOR RESIDUE ACT B 1860 source : BC4 73) chain B residue 587 type sequence W description BINDING SITE FOR RESIDUE ACT B 1860 source : BC4 74) chain B residue 364 type sequence Q description BINDING SITE FOR RESIDUE GOL B 881 source : BC5 75) chain B residue 669 type sequence R description BINDING SITE FOR RESIDUE GOL B 881 source : BC5 76) chain B residue 497 type sequence A description BINDING SITE FOR RESIDUE GOL B 883 source : BC6 77) chain B residue 569 type sequence N description BINDING SITE FOR RESIDUE GOL B 883 source : BC6 78) chain B residue 709 type sequence D description BINDING SITE FOR RESIDUE GOL B 883 source : BC6 79) chain B residue 604 type sequence Y description BINDING SITE FOR RESIDUE GOL B 884 source : BC7 80) chain B residue 605 type sequence N description BINDING SITE FOR RESIDUE GOL B 884 source : BC7 81) chain B residue 606 type sequence I description BINDING SITE FOR RESIDUE GOL B 884 source : BC7 82) chain B residue 609 type sequence E description BINDING SITE FOR RESIDUE GOL B 884 source : BC7 83) chain A residue 414-421 type prosite sequence RCVGRIQW description NOS Nitric oxide synthase (NOS) signature. RCVGRIqW source prosite : PS60001 84) chain A residue 334 type BINDING sequence S description BINDING => ECO:0000250|UniProtKB:P29475 source Swiss-Prot : SWS_FT_FI1 85) chain B residue 334 type BINDING sequence S description BINDING => ECO:0000250|UniProtKB:P29475 source Swiss-Prot : SWS_FT_FI1 86) chain B residue 478 type BINDING sequence Q description BINDING => ECO:0000250|UniProtKB:P29475 source Swiss-Prot : SWS_FT_FI1 87) chain B residue 587 type BINDING sequence W description BINDING => ECO:0000250|UniProtKB:P29475 source Swiss-Prot : SWS_FT_FI1 88) chain B residue 588 type BINDING sequence Y description BINDING => ECO:0000250|UniProtKB:P29475 source Swiss-Prot : SWS_FT_FI1 89) chain B residue 592 type BINDING sequence E description BINDING => ECO:0000250|UniProtKB:P29475 source Swiss-Prot : SWS_FT_FI1 90) chain B residue 677 type BINDING sequence V description BINDING => ECO:0000250|UniProtKB:P29475 source Swiss-Prot : SWS_FT_FI1 91) chain B residue 678 type BINDING sequence W description BINDING => ECO:0000250|UniProtKB:P29475 source Swiss-Prot : SWS_FT_FI1 92) chain B residue 691 type BINDING sequence F description BINDING => ECO:0000250|UniProtKB:P29475 source Swiss-Prot : SWS_FT_FI1 93) chain B residue 706 type BINDING sequence Y description BINDING => ECO:0000250|UniProtKB:P29475 source Swiss-Prot : SWS_FT_FI1 94) chain A residue 478 type BINDING sequence Q description BINDING => ECO:0000250|UniProtKB:P29475 source Swiss-Prot : SWS_FT_FI1 95) chain A residue 587 type BINDING sequence W description BINDING => ECO:0000250|UniProtKB:P29475 source Swiss-Prot : SWS_FT_FI1 96) chain A residue 588 type BINDING sequence Y description BINDING => ECO:0000250|UniProtKB:P29475 source Swiss-Prot : SWS_FT_FI1 97) chain A residue 592 type BINDING sequence E description BINDING => ECO:0000250|UniProtKB:P29475 source Swiss-Prot : SWS_FT_FI1 98) chain A residue 677 type BINDING sequence V description BINDING => ECO:0000250|UniProtKB:P29475 source Swiss-Prot : SWS_FT_FI1 99) chain A residue 678 type BINDING sequence W description BINDING => ECO:0000250|UniProtKB:P29475 source Swiss-Prot : SWS_FT_FI1 100) chain A residue 691 type BINDING sequence F description BINDING => ECO:0000250|UniProtKB:P29475 source Swiss-Prot : SWS_FT_FI1 101) chain A residue 706 type BINDING sequence Y description BINDING => ECO:0000250|UniProtKB:P29475 source Swiss-Prot : SWS_FT_FI1 102) chain A residue 415 type BINDING sequence C description axial binding residue => ECO:0000250|UniProtKB:P29475 source Swiss-Prot : SWS_FT_FI2 103) chain B residue 415 type BINDING sequence C description axial binding residue => ECO:0000250|UniProtKB:P29475 source Swiss-Prot : SWS_FT_FI2

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