eF-site ID 3hqr-AS PDB Code 3hqr Chain A, S click to enlarge Title PHD2:Mn:NOG:HIF1-alpha substrate complex Classification OXIDOREDUCTASE/TRANSCRIPTION Compound Egl nine homolog 1 Source Homo sapiens (Human) (HIF1A_HUMAN) Sequence A:  QTKPLPALKLALEYIVPCMNKHGICVVDDFLGKETGQQIG DEVRALHDTGKFTDGQLVSQKSDSSKDIRGDKITWIEGKE PGCETIGLLMSSMDDLIRHCNGKLGSYKINGRTKAMVACY PGNGTGYVRHVDNPNGDGRCVTCIYYLNKDWDAKVSGGIL RIFPEGKAQFADIEPKFDRLLFFWSDRRNPHEVQPAYATR YAITVWYFDADERAAAKVKYLTGEK S:  DLEMLAPYIPMDDDFQL Description Functional site 1) chain A residue 313 type sequence H description BINDING SITE FOR RESIDUE MN A 501 source : AC1 2) chain A residue 315 type sequence D description BINDING SITE FOR RESIDUE MN A 501 source : AC1 3) chain A residue 374 type sequence H description BINDING SITE FOR RESIDUE MN A 501 source : AC1 4) chain A residue 299 type sequence M description BINDING SITE FOR RESIDUE OGA A 600 source : AC2 5) chain A residue 310 type sequence Y description BINDING SITE FOR RESIDUE OGA A 600 source : AC2 6) chain A residue 313 type sequence H description BINDING SITE FOR RESIDUE OGA A 600 source : AC2 7) chain A residue 315 type sequence D description BINDING SITE FOR RESIDUE OGA A 600 source : AC2 8) chain A residue 327 type sequence I description BINDING SITE FOR RESIDUE OGA A 600 source : AC2 9) chain A residue 329 type sequence Y description BINDING SITE FOR RESIDUE OGA A 600 source : AC2 10) chain A residue 343 type sequence L description BINDING SITE FOR RESIDUE OGA A 600 source : AC2 11) chain A residue 374 type sequence H description BINDING SITE FOR RESIDUE OGA A 600 source : AC2 12) chain A residue 376 type sequence V description BINDING SITE FOR RESIDUE OGA A 600 source : AC2 13) chain A residue 383 type sequence R description BINDING SITE FOR RESIDUE OGA A 600 source : AC2 14) chain S residue 564 type sequence P description BINDING SITE FOR RESIDUE OGA A 600 source : AC2 15) chain A residue 201 type MOD_RES sequence C description S-nitrosocysteine => ECO:0000269|PubMed:21601578 source Swiss-Prot : SWS_FT_FI3 16) chain A residue 208 type MOD_RES sequence C description S-nitrosocysteine => ECO:0000269|PubMed:21601578 source Swiss-Prot : SWS_FT_FI3 17) chain A residue 302 type MOD_RES sequence C description S-nitrosocysteine => ECO:0000269|PubMed:21601578 source Swiss-Prot : SWS_FT_FI3 18) chain A residue 323 type MOD_RES sequence C description S-nitrosocysteine => ECO:0000269|PubMed:21601578 source Swiss-Prot : SWS_FT_FI3 19) chain A residue 326 type MOD_RES sequence C description S-nitrosocysteine => ECO:0000269|PubMed:21601578 source Swiss-Prot : SWS_FT_FI3 20) chain S residue 564 type MOD_RES sequence P description 4-hydroxyproline => ECO:0000269|PubMed:11292861, ECO:0000269|PubMed:11566883, ECO:0000269|PubMed:12351678, ECO:0000269|PubMed:25974097 source Swiss-Prot : SWS_FT_FI1 21) chain A residue 315 type MOD_RES sequence D description 4-hydroxyproline => ECO:0000269|PubMed:11292861, ECO:0000269|PubMed:11566883, ECO:0000269|PubMed:12351678, ECO:0000269|PubMed:25974097 source Swiss-Prot : SWS_FT_FI1 22) chain A residue 374 type MOD_RES sequence H description 4-hydroxyproline => ECO:0000269|PubMed:11292861, ECO:0000269|PubMed:11566883, ECO:0000269|PubMed:12351678, ECO:0000269|PubMed:25974097 source Swiss-Prot : SWS_FT_FI1 23) chain A residue 383 type BINDING sequence R description BINDING => ECO:0000305|PubMed:19604478 source Swiss-Prot : SWS_FT_FI2

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