eF-site ID 3hp2-A PDB Code 3hp2 Chain A click to enlarge Title Crystal Structure of Human p38alpha complexed with a pyridinone compound Classification TRANSFERASE Compound Mitogen-activated protein kinase 14 Source Homo sapiens (Human) (MK14_HUMAN) Sequence A:  ERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFD TKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENV IGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLT DDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCE LKILDFGLVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMA ELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSES ARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSD KRITAAQALAHAYFAQYHDPDDEPVADPYDQSFESRDLLI DEWKSLTYDEVISFVPPPLDQ Description Functional site 1) chain A residue 51 type sequence A description BINDING SITE FOR RESIDUE P36 A 401 source : AC1 2) chain A residue 104 type sequence L description BINDING SITE FOR RESIDUE P36 A 401 source : AC1 3) chain A residue 106 type sequence T description BINDING SITE FOR RESIDUE P36 A 401 source : AC1 4) chain A residue 107 type sequence H description BINDING SITE FOR RESIDUE P36 A 401 source : AC1 5) chain A residue 109 type sequence M description BINDING SITE FOR RESIDUE P36 A 401 source : AC1 6) chain A residue 110 type sequence G description BINDING SITE FOR RESIDUE P36 A 401 source : AC1 7) chain A residue 111 type sequence A description BINDING SITE FOR RESIDUE P36 A 401 source : AC1 8) chain A residue 167 type sequence L description BINDING SITE FOR RESIDUE P36 A 401 source : AC1 9) chain A residue 171 type sequence L description BINDING SITE FOR RESIDUE P36 A 401 source : AC1 10) chain A residue 192 type sequence E description BINDING SITE FOR RESIDUE I46 A 402 source : AC2 11) chain A residue 195 type sequence L description BINDING SITE FOR RESIDUE I46 A 402 source : AC2 12) chain A residue 197 type sequence W description BINDING SITE FOR RESIDUE I46 A 402 source : AC2 13) chain A residue 242 type sequence P description BINDING SITE FOR RESIDUE I46 A 402 source : AC2 14) chain A residue 246 type sequence L description BINDING SITE FOR RESIDUE I46 A 402 source : AC2 15) chain A residue 249 type sequence K description BINDING SITE FOR RESIDUE I46 A 402 source : AC2 16) chain A residue 250 type sequence I description BINDING SITE FOR RESIDUE I46 A 402 source : AC2 17) chain A residue 259 type sequence I description BINDING SITE FOR RESIDUE I46 A 402 source : AC2 18) chain A residue 291 type sequence L description BINDING SITE FOR RESIDUE I46 A 402 source : AC2 19) chain A residue 293 type sequence S description BINDING SITE FOR RESIDUE I46 A 402 source : AC2 20) chain A residue 22 type sequence E description BINDING SITE FOR RESIDUE I46 A 403 source : AC3 21) chain A residue 44 type sequence T description BINDING SITE FOR RESIDUE I46 A 403 source : AC3 22) chain A residue 194 type sequence M description BINDING SITE FOR RESIDUE I46 A 403 source : AC3 23) chain A residue 195 type sequence L description BINDING SITE FOR RESIDUE I46 A 403 source : AC3 24) chain A residue 228 type sequence H description BINDING SITE FOR RESIDUE I46 A 403 source : AC3 25) chain A residue 229 type sequence I description BINDING SITE FOR RESIDUE I46 A 403 source : AC3 26) chain A residue 232 type sequence L description BINDING SITE FOR RESIDUE I46 A 403 source : AC3 27) chain A residue 254 type sequence S description BINDING SITE FOR RESIDUE I46 A 403 source : AC3 28) chain A residue 255 type sequence A description BINDING SITE FOR RESIDUE I46 A 403 source : AC3 29) chain A residue 258 type sequence Y description BINDING SITE FOR RESIDUE I46 A 403 source : AC3 30) chain A residue 168 type ACT_SITE sequence D description Proton acceptor source Swiss-Prot : SWS_FT_FI1 31) chain A residue 30 type BINDING sequence V description source Swiss-Prot : SWS_FT_FI2 32) chain A residue 53 type BINDING sequence K description source Swiss-Prot : SWS_FT_FI2 33) chain A residue 30-54 type prosite sequence VGSGAYGSVCAAFDTKTGLRVAVKK description PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. VGSGAYGSVCaAfdtktglrv.........AVKK source prosite : PS00107 34) chain A residue 59-162 type prosite sequence FQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEE FNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGL KYIHSADIIHRDLKPSNLAVNEDC description MAPK MAP kinase signature. FqsiihakrtyRElrllkhmkhenviglldvftparsleefndvylvthlmgadlnnivkcqkltddhvqfliyqilrglkyihsadiih.........RDlKpsnlavnedC source prosite : PS01351 35) chain A residue 16 type MOD_RES sequence T description Phosphothreonine => ECO:0007744|PubMed:18691976 source Swiss-Prot : SWS_FT_FI4 36) chain A residue 53 type MOD_RES sequence K description N6-acetyllysine => ECO:0000269|PubMed:21444723 source Swiss-Prot : SWS_FT_FI5 37) chain A residue 152 type MOD_RES sequence K description N6-acetyllysine => ECO:0000269|PubMed:21444723 source Swiss-Prot : SWS_FT_FI5 38) chain A residue 263 type MOD_RES sequence T description Phosphothreonine => ECO:0007744|PubMed:17525332 source Swiss-Prot : SWS_FT_FI8 39) chain A residue 323 type MOD_RES sequence Y description Phosphotyrosine; by ZAP70 => ECO:0000269|PubMed:15735648 source Swiss-Prot : SWS_FT_FI9

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