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eF-site ID
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3hiz-AB |
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PDB Code
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3hiz |
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Chain
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A, B |
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click to enlarge
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Title
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Crystal structure of p110alpha H1047R mutant in complex with niSH2 of p85alpha |
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Classification
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TRANSFERASE/ONCOPROTEIN |
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Compound
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Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform |
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Source
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null (P85A_HUMAN) |
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Sequence
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A: |
SYYHHHHHHDYDIPTTEPSSGELWGIHLMPPRILVECLLP
NGMIVTLECLREATLITIKHELFKEARKYPLHQLLQDESS
YIFVSVTQEAEREEFFDETRRLCDLRLFQPFLKVIEPVGN
REEKILNREIGFAIGMPVCEFDMVKDPEVQDFRRNILNVC
KEAVDLRDLNSPHSRAMYVYPPNVESSPELPKHIYNKLDK
GQIIVVIWVIVSPNNDKQKYTLKINHDCVPEQVIAEAIRK
KTRSMLLSSEQLKLCVLEYQGKYILKVCGCDEYFLEKYPL
SQYKYIRSCIMLGRMPNLMLMAKESLYSQLPMDCFTMPSY
SRETSTKSLWVINSALRIKILCATYVNVNIRDIDKIYVRT
GIYHGGEPLCDNVNTQRVPCSNPRWNEWLNYDIYIPDLPR
AARLCLSICSVKGRKGAKEPLAWGNINLFDYTDTLVSGKM
ALNLWPVPHGLEDLLNPIGVTGSNPNKETPCLELEFDWFS
SVVKFPDMSVIEEHANWSVSREAGFSYSHAGLSNRRENDK
EQLKAISTRDPLSEITEQEKDFLWSHRHYCVTIPEILPKL
LLSVKWNSRDEVAQMYCLVKDWPPIKPEQAMELLDCNYPD
PMVRGFAVRCLEKYLTDDKLSQYLIQLVQVLKYEQYLDNL
LVRFLLKKALTNQRIGHFFFWHLKSEMHNKTVSQRFGLLL
ESYCRACGMYLKHLNRQVEAMEKLINLTDILKQEKKDETQ
KVQMKFLVEQMRRPDFMDALQGFLSPLNPAHQLGNLRLEE
CRIMSSAKRPLWLNWENPDIMSELLFQNNEIIFKNGDDLR
QDMLTLQIIRIMENIWQNQGLDLRMLPYGCLSIGDCVGLI
EVVRNSHTIMQIQCNSHTLHQWLKDKNKGEIYDAAIDLFT
RSCAGYCVATFILGIGDRHNSNIMVKDDGQLFHIDFGHFL
DHPFVLTQDFLIVISKGAQETKTREFERFQEMCYKAYLAI
RQHANLFINLFSMMLGSGMPELQSFDDIAYIRKTLALDKT
EQEALEYFMKQMNDARHDWIFHTI
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| B: |
SLQNAEWYWGDISREEVNEKLRDTADGTFLVRDASTKMHG
DYTLTLRKGGNNKLIKIFHRDGKYGFSDPLTFSSVVELIN
HYLAQYNPKLDVKLLYPVSKYKKLHEYNTQFQEKSREYDR
LYEEYTRTSQEIQMKRTAIEAFNETIKIFEEQCQTQERYS
KEYIEKFKREGNEKEIQRIMHNYDKLKSRISEIIDSRRRL
EEDLKKQAAEYREIDKRMNSIKPDLIQLRKTRDQ
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Description
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Functional site
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1)
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chain |
B |
| residue |
467 |
| type |
MOD_RES |
| sequence |
Y
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| description |
Phosphotyrosine => ECO:0000250|UniProtKB:P26450
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| source |
Swiss-Prot : SWS_FT_FI1
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2)
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chain |
A |
| residue |
801-815 |
| type |
prosite |
| sequence |
FKNGDDLRQDMLTLQ
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| description |
PI3_4_KINASE_1 Phosphatidylinositol 3- and 4-kinases signature 1. FKng.DDLRQDmltlQ
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| source |
prosite : PS00915
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3)
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chain |
A |
| residue |
900-920 |
| type |
prosite |
| sequence |
SCAGYCVATFILGIGDRHNSN
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| description |
PI3_4_KINASE_2 Phosphatidylinositol 3- and 4-kinases signature 2. ScAgycVatFILgIgDRHnsN
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| source |
prosite : PS00916
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