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|
eF-site ID
|
3hhm-B |
|
PDB Code
|
3hhm |
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Chain
|
B |
|
|
|
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Title
|
Crystal structure of p110alpha H1047R mutant in complex with niSH2 of p85alpha and the drug wortmannin |
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Classification
|
TRANSFERASE/ONCOPROTEIN |
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Compound
|
Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform |
|
Source
|
(P85A_HUMAN) |
|
|
Sequence
|
B: |
MSLQNAEWYWGDISREEVNEKLRDTADGTFLVRDASTKGD
YTLTLRKGGNNKLIKIFHRDGKYGFSDPLTFSSVVELINH
YRNESLAQYNPKLDVKLLYPVSKYQQQVVKEDEAVGKHEY
NTQFQEKSREYDRLYEEYTRTSQEIQMKRTAIEAFNETIK
IFEEQCQTQERYSKEYIEKFKREGNEKEIQRIMHNYDKLK
SRISEIIDSRRRLEEDLKKQAAEYREIDKRMNSIKPDLIQ
LRKTRDQ
|
|
|
Description
|
|
Functional site
|
|
|
1)
|
chain |
B |
| residue |
467 |
| type |
MOD_RES |
| sequence |
Y
|
| description |
Phosphotyrosine => ECO:0000250|UniProtKB:P26450
|
| source |
Swiss-Prot : SWS_FT_FI1
|
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