eF-site ID 3hhm-AB PDB Code 3hhm Chain A, B click to enlarge Title Crystal structure of p110alpha H1047R mutant in complex with niSH2 of p85alpha and the drug wortmannin Classification TRANSFERASE/ONCOPROTEIN Compound Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Source (P85A_HUMAN) Sequence A:  SYYHHHHHHDYPSSGELWGIHLMPPRILVECLLPNGMIVT LECLREATLITIKHELFKEARKYPLHQLLQDESSYIFVSV TQEAEREEFFDETRRLCDLRLFQPFLKVIEPVGNREEKIL NREIGFAIGMPVCEFDMVKDPEVQDFRRNILNVCKEAVDL RDLNSPHSRAMYVYPPNVESSPELPKHIYNKLDKGQIIVV IWVIVSPNNDKQKYTLKINHDCVPEQVIAEAIRKKTRSML LSSEQLKLCVLEYQGKYILKVCGCDEYFLEKYPLSQYKYI RSCIMLGRMPNLMLMAKESLYSQLPMDCFTMPSYSRETST KSLWVINSALRIKILCATYVNVNIRDIDKIYVRTGIYHGG EPLCDNVNTQRVPCSNPRWNEWLNYDIYIPDLPRAARLCL SICSVKGRKPLAWGNINLFDYTDTLVSGKMALNLWPVPHG LEDLLNPIGVTGSNPNKETPCLELEFDWFSSVVKFPDMSV IEEHANWSVSREAGFSYSHAGLSNRRENDKEQLKAISTRD PLSEITEQEKDFLWSHRHYCVTIPEILPKLLLSVKWNSRD EVAQMYCLVKDWPPIKPEQAMELLDCNYPDPMVRGFAVRC LEKYLTDDKLSQYLIQLVQVLKYEQYLDNLLVRFLLKKAL TNQRIGHFFFWHLKSEMHNKTVSQRFGLLLESYCRACGMY LKHLNRQVEAMEKLINLTDILKQEKKDETQKVQMKFLVEQ MRRPDFMDALQGFLSPLNPAHQLGNLRLEECRIMSSAKRP LWLNWENPDIMSELLFQNNEIIFKNGDDLRQDMLTLQIIR IMENIWQNQGLDLRMLPYGCLSIGDCVGLIEVVRNSHTIM QIQCKGGLKGALQFNSHTLHQWLKDKNKGEIYDAAIDLFT RSCAGYCVATFILGIGDRHNSNIMVKDDGQLFHIDFGHFL DHPFVLTQDFLIVISKGAQECTKTREFERFQEMCYKAYLA IRQHANLFINLFSMMLGSGMPELQSFDDIAYIRKTLALDK TEQEALEYFMKQMNDARHGGWTTKMDWIFHTI B:  MSLQNAEWYWGDISREEVNEKLRDTADGTFLVRDASTKGD YTLTLRKGGNNKLIKIFHRDGKYGFSDPLTFSSVVELINH YRNESLAQYNPKLDVKLLYPVSKYQQQVVKEDEAVGKHEY NTQFQEKSREYDRLYEEYTRTSQEIQMKRTAIEAFNETIK IFEEQCQTQERYSKEYIEKFKREGNEKEIQRIMHNYDKLK SRISEIIDSRRRLEEDLKKQAAEYREIDKRMNSIKPDLIQ LRKTRDQ Description Functional site 1) chain A residue 233 type sequence L description BINDING SITE FOR RESIDUE KWT A 1833 source : AC1 2) chain A residue 774 type sequence S description BINDING SITE FOR RESIDUE KWT A 1833 source : AC1 3) chain A residue 776 type sequence K description BINDING SITE FOR RESIDUE KWT A 1833 source : AC1 4) chain A residue 778 type sequence P description BINDING SITE FOR RESIDUE KWT A 1833 source : AC1 5) chain A residue 780 type sequence W description BINDING SITE FOR RESIDUE KWT A 1833 source : AC1 6) chain A residue 800 type sequence I description BINDING SITE FOR RESIDUE KWT A 1833 source : AC1 7) chain A residue 802 type sequence K description BINDING SITE FOR RESIDUE KWT A 1833 source : AC1 8) chain A residue 836 type sequence Y description BINDING SITE FOR RESIDUE KWT A 1833 source : AC1 9) chain A residue 849 type sequence E description BINDING SITE FOR RESIDUE KWT A 1833 source : AC1 10) chain A residue 850 type sequence V description BINDING SITE FOR RESIDUE KWT A 1833 source : AC1 11) chain A residue 851 type sequence V description BINDING SITE FOR RESIDUE KWT A 1833 source : AC1 12) chain A residue 932 type sequence I description BINDING SITE FOR RESIDUE KWT A 1833 source : AC1 13) chain A residue 933 type sequence D description BINDING SITE FOR RESIDUE KWT A 1833 source : AC1 14) chain A residue 801-815 type prosite sequence FKNGDDLRQDMLTLQ description PI3_4_KINASE_1 Phosphatidylinositol 3- and 4-kinases signature 1. FKng.DDLRQDmltlQ source prosite : PS00915 15) chain A residue 900-920 type prosite sequence SCAGYCVATFILGIGDRHNSN description PI3_4_KINASE_2 Phosphatidylinositol 3- and 4-kinases signature 2. ScAgycVatFILgIgDRHnsN source prosite : PS00916 16) chain B residue 467 type MOD_RES sequence Y description Phosphotyrosine => ECO:0000250|UniProtKB:P26450 source Swiss-Prot : SWS_FT_FI1

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