eF-site ID 3hhm-A PDB Code 3hhm Chain A click to enlarge Title Crystal structure of p110alpha H1047R mutant in complex with niSH2 of p85alpha and the drug wortmannin Classification TRANSFERASE/ONCOPROTEIN Compound Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Source (P85A_HUMAN) Sequence A:  SYYHHHHHHDYPSSGELWGIHLMPPRILVECLLPNGMIVT LECLREATLITIKHELFKEARKYPLHQLLQDESSYIFVSV TQEAEREEFFDETRRLCDLRLFQPFLKVIEPVGNREEKIL NREIGFAIGMPVCEFDMVKDPEVQDFRRNILNVCKEAVDL RDLNSPHSRAMYVYPPNVESSPELPKHIYNKLDKGQIIVV IWVIVSPNNDKQKYTLKINHDCVPEQVIAEAIRKKTRSML LSSEQLKLCVLEYQGKYILKVCGCDEYFLEKYPLSQYKYI RSCIMLGRMPNLMLMAKESLYSQLPMDCFTMPSYSRETST KSLWVINSALRIKILCATYVNVNIRDIDKIYVRTGIYHGG EPLCDNVNTQRVPCSNPRWNEWLNYDIYIPDLPRAARLCL SICSVKGRKPLAWGNINLFDYTDTLVSGKMALNLWPVPHG LEDLLNPIGVTGSNPNKETPCLELEFDWFSSVVKFPDMSV IEEHANWSVSREAGFSYSHAGLSNRRENDKEQLKAISTRD PLSEITEQEKDFLWSHRHYCVTIPEILPKLLLSVKWNSRD EVAQMYCLVKDWPPIKPEQAMELLDCNYPDPMVRGFAVRC LEKYLTDDKLSQYLIQLVQVLKYEQYLDNLLVRFLLKKAL TNQRIGHFFFWHLKSEMHNKTVSQRFGLLLESYCRACGMY LKHLNRQVEAMEKLINLTDILKQEKKDETQKVQMKFLVEQ MRRPDFMDALQGFLSPLNPAHQLGNLRLEECRIMSSAKRP LWLNWENPDIMSELLFQNNEIIFKNGDDLRQDMLTLQIIR IMENIWQNQGLDLRMLPYGCLSIGDCVGLIEVVRNSHTIM QIQCKGGLKGALQFNSHTLHQWLKDKNKGEIYDAAIDLFT RSCAGYCVATFILGIGDRHNSNIMVKDDGQLFHIDFGHFL DHPFVLTQDFLIVISKGAQECTKTREFERFQEMCYKAYLA IRQHANLFINLFSMMLGSGMPELQSFDDIAYIRKTLALDK TEQEALEYFMKQMNDARHGGWTTKMDWIFHTI Description Functional site 1) chain A residue 233 type sequence L description BINDING SITE FOR RESIDUE KWT A 1833 source : AC1 2) chain A residue 774 type sequence S description BINDING SITE FOR RESIDUE KWT A 1833 source : AC1 3) chain A residue 776 type sequence K description BINDING SITE FOR RESIDUE KWT A 1833 source : AC1 4) chain A residue 778 type sequence P description BINDING SITE FOR RESIDUE KWT A 1833 source : AC1 5) chain A residue 780 type sequence W description BINDING SITE FOR RESIDUE KWT A 1833 source : AC1 6) chain A residue 800 type sequence I description BINDING SITE FOR RESIDUE KWT A 1833 source : AC1 7) chain A residue 802 type sequence K description BINDING SITE FOR RESIDUE KWT A 1833 source : AC1 8) chain A residue 836 type sequence Y description BINDING SITE FOR RESIDUE KWT A 1833 source : AC1 9) chain A residue 849 type sequence E description BINDING SITE FOR RESIDUE KWT A 1833 source : AC1 10) chain A residue 850 type sequence V description BINDING SITE FOR RESIDUE KWT A 1833 source : AC1 11) chain A residue 851 type sequence V description BINDING SITE FOR RESIDUE KWT A 1833 source : AC1 12) chain A residue 932 type sequence I description BINDING SITE FOR RESIDUE KWT A 1833 source : AC1 13) chain A residue 933 type sequence D description BINDING SITE FOR RESIDUE KWT A 1833 source : AC1 14) chain A residue 801-815 type prosite sequence FKNGDDLRQDMLTLQ description PI3_4_KINASE_1 Phosphatidylinositol 3- and 4-kinases signature 1. FKng.DDLRQDmltlQ source prosite : PS00915 15) chain A residue 900-920 type prosite sequence SCAGYCVATFILGIGDRHNSN description PI3_4_KINASE_2 Phosphatidylinositol 3- and 4-kinases signature 2. ScAgycVatFILgIgDRHnsN source prosite : PS00916

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