eF-site ID 3hha-D PDB Code 3hha Chain D click to enlarge Title Crystal structure of cathepsin L in complex with AZ12878478 Classification HYDROLASE Compound Cathepsin L1 Source Homo sapiens (Human) (CATL1_HUMAN) Sequence D:  APRSVDWREKGYVTPVKNQGQCGSCWAFSATGALEGQMFR KTGRLISLSEQNLVDCSGPQGNEGCNGGLMDYAFQYVQDN GGLDSEESYPYEATEESCKYNPKYSVANDAGFVDIPKQEK ALMKAVATVGPISVAIDAGHESFLFYKEGIYFEPDCSSED MDHGVLVVGYGFESTESDNNKYWLVKNSWGEEWGMGGYVK MAKDRRNHCGIASAASYPTV Description Functional site 1) chain D residue 19 type sequence Q description BINDING SITE FOR RESIDUE NOW D 301 source : AC7 2) chain D residue 23 type sequence G description BINDING SITE FOR RESIDUE NOW D 301 source : AC7 3) chain D residue 24 type sequence S description BINDING SITE FOR RESIDUE NOW D 301 source : AC7 4) chain D residue 25 type sequence C description BINDING SITE FOR RESIDUE NOW D 301 source : AC7 5) chain D residue 26 type sequence W description BINDING SITE FOR RESIDUE NOW D 301 source : AC7 6) chain D residue 61 type sequence G description BINDING SITE FOR RESIDUE NOW D 301 source : AC7 7) chain D residue 67 type sequence G description BINDING SITE FOR RESIDUE NOW D 301 source : AC7 8) chain D residue 68 type sequence G description BINDING SITE FOR RESIDUE NOW D 301 source : AC7 9) chain D residue 69 type sequence L description BINDING SITE FOR RESIDUE NOW D 301 source : AC7 10) chain D residue 135 type sequence A description BINDING SITE FOR RESIDUE NOW D 301 source : AC7 11) chain D residue 161 type sequence M description BINDING SITE FOR RESIDUE NOW D 301 source : AC7 12) chain D residue 162 type sequence D description BINDING SITE FOR RESIDUE NOW D 301 source : AC7 13) chain D residue 17 type sequence K description BINDING SITE FOR RESIDUE GOL D 221 source : AC8 14) chain D residue 18 type sequence N description BINDING SITE FOR RESIDUE GOL D 221 source : AC8 15) chain D residue 86 type sequence E description BINDING SITE FOR RESIDUE GOL D 221 source : AC8 16) chain D residue 108 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:12754519, ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:19159218 source Swiss-Prot : SWS_FT_FI3 17) chain D residue 163 type ACT_SITE sequence H description source Swiss-Prot : SWS_FT_FI2 18) chain D residue 187 type ACT_SITE sequence N description source Swiss-Prot : SWS_FT_FI2 19) chain D residue 25 type ACT_SITE sequence C description ACT_SITE => ECO:0000305|PubMed:9468501 source Swiss-Prot : SWS_FT_FI1

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