eF-site ID 3hg1-ABCDE PDB Code 3hg1 Chain A, B, C, D, E click to enlarge Title Germline-governed recognition of a cancer epitope by an immunodominant human T cell receptor Classification IMMUNE SYSTEM Compound MHC class I antigen Source ORGANISM_COMMON: human; ORGANISM_SCIENTIFIC: HOMO SAPIENS; Sequence A:  GSHSMRYFFTSVSRPGRGEPRFIAVGYVDDTQFVRFDSDA ASQRMEPRAPWIEQEGPEYWDGETRKVKAHSQTHRVDLGT LRGYYNQSEAGSHTVQRMYGCDVGSDWRFLRGYHQYAYDG KDYIALKEDLRSWTAADMAAQTTKHKWEAAHVAEQLRAYL EGTCVEWLRRYLENGKETLQRTDAPKTHMTHHAVSDHEAT LRCWALSFYPAEITLTWQRDGEDQTQDTELVETRPAGDGT FQKWAAVVVPSGQEQRYTCHVQHEGLPKPLTLRWEP B:  MIQRTPKIQVYSRHPAENGKSNFLNCYVSGFHPSDIEVDL LKNGERIEKVEHSDLSFSKDWSFYLLYYTEFTPTEKDEYA CRVNHVTLSQPKIVKWDRDM C:  ELAGIGILTV D:  QEVEQNSGPLSVPEGAIASLNCTYSDRGSQSFFWYRQYSG KSPELIMFIYSNGDKEDGRFTAQLNKASQYVSLLIRDSQP SDSATYLCAVNVAGKSTFGDGTTLTVKPNIQNPDPAVYQL RDSKSSDKSVCLFTDFDSQTNVSQSKDSDVYITDKCVLDM RSMDFKSNSAVAWSNKSDFACANAFNNSIIPEDT E:  SQTIHQWPATLVQPVGSPLSLECTVEGTSNPNLYWYRQAA GRGLQLLFYSVGIGQISSEVPQNLSASRPQDRQFILSSKK LLLSDSGFYLCAWSETGLGTGELFFGEGSRLTVLEDLKNV FPPEVAVFEPSEAEISHTQKATLVCLATGFYPDHVELSWW VNGKEVHSGVCTDPQPLKEQPALNDSRYALSSRLRVSATF WQDPRNHFRCQVQFYGLSENDEWTQDRAKPVTQIVSAEAW GRAD Description (1)  MHC class I antigen, Beta-2-microglobulin, CANCER/MART-1, T-CELL RECEPTOR, ALPHA CHAIN, T-cell Receptor, Beta Chain Functional site 1) chain A residue 105 type sequence S description BINDING SITE FOR RESIDUE GOL A 801 source : AC1 2) chain A residue 107 type sequence W description BINDING SITE FOR RESIDUE GOL A 801 source : AC1 3) chain A residue 6 type sequence R description BINDING SITE FOR RESIDUE SO4 A 803 source : AC2 4) chain A residue 27 type sequence Y description BINDING SITE FOR RESIDUE SO4 A 803 source : AC2 5) chain A residue 29 type sequence D description BINDING SITE FOR RESIDUE SO4 A 803 source : AC2 6) chain A residue 30 type sequence D description BINDING SITE FOR RESIDUE SO4 A 803 source : AC2 7) chain A residue 233 type sequence T description BINDING SITE FOR RESIDUE SO4 A 804 source : AC3 8) chain A residue 241 type sequence F description BINDING SITE FOR RESIDUE SO4 A 804 source : AC3 9) chain E residue 13 type sequence Q description BINDING SITE FOR RESIDUE GOL E 802 source : AC4 10) chain E residue 14 type sequence P description BINDING SITE FOR RESIDUE GOL E 802 source : AC4 11) chain E residue 219 type sequence E description BINDING SITE FOR RESIDUE GOL E 802 source : AC4 12) chain E residue 220 type sequence N description BINDING SITE FOR RESIDUE GOL E 802 source : AC4 13) chain B residue 19 type CARBOHYD sequence K description N-linked (Glc) (glycation) lysine; in vitro => ECO:0000269|PubMed:7918443 source Swiss-Prot : SWS_FT_FI3 14) chain B residue 41 type CARBOHYD sequence K description N-linked (Glc) (glycation) lysine; in vitro => ECO:0000269|PubMed:7918443 source Swiss-Prot : SWS_FT_FI3 15) chain B residue 48 type CARBOHYD sequence K description N-linked (Glc) (glycation) lysine; in vitro => ECO:0000269|PubMed:7918443 source Swiss-Prot : SWS_FT_FI3 16) chain B residue 58 type CARBOHYD sequence K description N-linked (Glc) (glycation) lysine; in vitro => ECO:0000269|PubMed:7918443 source Swiss-Prot : SWS_FT_FI3 17) chain B residue 91 type CARBOHYD sequence K description N-linked (Glc) (glycation) lysine; in vitro => ECO:0000269|PubMed:7918443 source Swiss-Prot : SWS_FT_FI3 18) chain B residue 94 type CARBOHYD sequence K description N-linked (Glc) (glycation) lysine; in vitro => ECO:0000269|PubMed:7918443 source Swiss-Prot : SWS_FT_FI3 19) chain E residue 184 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000255|PROSITE-ProRule:PRU00498 source Swiss-Prot : SWS_FT_FI1 20) chain D residue 176 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000255|PROSITE-ProRule:PRU00498 source Swiss-Prot : SWS_FT_FI1 21) chain D residue 187 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000255|PROSITE-ProRule:PRU00498 source Swiss-Prot : SWS_FT_FI2 22) chain B residue 78-84 type prosite sequence YACRVNH description IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YACRVNH source prosite : PS00290 23) chain A residue 257-263 type prosite sequence YTCHVQH description IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YACRVNH source prosite : PS00290

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