eF-site ID 3hfg-D PDB Code 3hfg Chain D click to enlarge Title Crystal Structure of Human 11-beta-hydroxysteroid-dehydrogenase Bound to an Sulfonyl-piperazine Inhibitor Classification OXIDOREDUCTASE Compound Corticosteroid 11-beta-dehydrogenase isozyme 1 Source Homo sapiens (Human) (DHI1_HUMAN) Sequence D:  EEFRPEMLQGKKVIVTGASKGIGREMAYHLAKMGAHVVVT ARSKETLQKVVSHCLELGAASAHYIAGTMEDMTFAEQFVA QAGKLMGGLDMLILNHITNTSLNLFHDDIHHVRKSMEVNF LSYVVLTVAALPMLKQSNGSIVVVSSLAGKVAYPMVAAYS ASKFALDGFFSSIRKEYSVSRVNVSITLCVLGLIDTETAM KAVSGMQAAPKEECALEIIKGGALRQEEVYYDSSLWTTLL IRNPSRKILEFLYS Description Functional site 1) chain D residue 280 type sequence Y description BINDING SITE FOR RESIDUE 17R C 1 source : AC5 2) chain D residue 121 type sequence I description BINDING SITE FOR RESIDUE 17R D 1 source : AC7 3) chain D residue 126 type sequence L description BINDING SITE FOR RESIDUE 17R D 1 source : AC7 4) chain D residue 170 type sequence S description BINDING SITE FOR RESIDUE 17R D 1 source : AC7 5) chain D residue 171 type sequence L description BINDING SITE FOR RESIDUE 17R D 1 source : AC7 6) chain D residue 172 type sequence A description BINDING SITE FOR RESIDUE 17R D 1 source : AC7 7) chain D residue 177 type sequence Y description BINDING SITE FOR RESIDUE 17R D 1 source : AC7 8) chain D residue 178 type sequence P description BINDING SITE FOR RESIDUE 17R D 1 source : AC7 9) chain D residue 183 type sequence Y description BINDING SITE FOR RESIDUE 17R D 1 source : AC7 10) chain D residue 216 type sequence G description BINDING SITE FOR RESIDUE 17R D 1 source : AC7 11) chain D residue 217 type sequence L description BINDING SITE FOR RESIDUE 17R D 1 source : AC7 12) chain D residue 222 type sequence T description BINDING SITE FOR RESIDUE 17R D 1 source : AC7 13) chain D residue 226 type sequence A description BINDING SITE FOR RESIDUE 17R D 1 source : AC7 14) chain D residue 41 type sequence G description BINDING SITE FOR RESIDUE NAP D 293 source : AC8 15) chain D residue 42 type sequence A description BINDING SITE FOR RESIDUE NAP D 293 source : AC8 16) chain D residue 43 type sequence S description BINDING SITE FOR RESIDUE NAP D 293 source : AC8 17) chain D residue 44 type sequence K description BINDING SITE FOR RESIDUE NAP D 293 source : AC8 18) chain D residue 45 type sequence G description BINDING SITE FOR RESIDUE NAP D 293 source : AC8 19) chain D residue 46 type sequence I description BINDING SITE FOR RESIDUE NAP D 293 source : AC8 20) chain D residue 65 type sequence A description BINDING SITE FOR RESIDUE NAP D 293 source : AC8 21) chain D residue 66 type sequence R description BINDING SITE FOR RESIDUE NAP D 293 source : AC8 22) chain D residue 67 type sequence S description BINDING SITE FOR RESIDUE NAP D 293 source : AC8 23) chain D residue 92 type sequence T description BINDING SITE FOR RESIDUE NAP D 293 source : AC8 24) chain D residue 93 type sequence M description BINDING SITE FOR RESIDUE NAP D 293 source : AC8 25) chain D residue 119 type sequence N description BINDING SITE FOR RESIDUE NAP D 293 source : AC8 26) chain D residue 120 type sequence H description BINDING SITE FOR RESIDUE NAP D 293 source : AC8 27) chain D residue 121 type sequence I description BINDING SITE FOR RESIDUE NAP D 293 source : AC8 28) chain D residue 168 type sequence V description BINDING SITE FOR RESIDUE NAP D 293 source : AC8 29) chain D residue 169 type sequence S description BINDING SITE FOR RESIDUE NAP D 293 source : AC8 30) chain D residue 170 type sequence S description BINDING SITE FOR RESIDUE NAP D 293 source : AC8 31) chain D residue 183 type sequence Y description BINDING SITE FOR RESIDUE NAP D 293 source : AC8 32) chain D residue 187 type sequence K description BINDING SITE FOR RESIDUE NAP D 293 source : AC8 33) chain D residue 216 type sequence G description BINDING SITE FOR RESIDUE NAP D 293 source : AC8 34) chain D residue 218 type sequence I description BINDING SITE FOR RESIDUE NAP D 293 source : AC8 35) chain D residue 220 type sequence T description BINDING SITE FOR RESIDUE NAP D 293 source : AC8 36) chain D residue 222 type sequence T description BINDING SITE FOR RESIDUE NAP D 293 source : AC8 37) chain D residue 223 type sequence A description BINDING SITE FOR RESIDUE NAP D 293 source : AC8 38) chain D residue 183 type ACT_SITE sequence Y description Proton acceptor source Swiss-Prot : SWS_FT_FI2 39) chain D residue 41 type BINDING sequence G description BINDING => ECO:0000269|PubMed:15513927, ECO:0000269|PubMed:17919905, ECO:0000269|PubMed:18069989, ECO:0000269|PubMed:18485702, ECO:0000269|PubMed:18553955, ECO:0000269|PubMed:19217779 source Swiss-Prot : SWS_FT_FI3 40) chain D residue 92 type BINDING sequence T description BINDING => ECO:0000269|PubMed:15513927, ECO:0000269|PubMed:17919905, ECO:0000269|PubMed:18069989, ECO:0000269|PubMed:18485702, ECO:0000269|PubMed:18553955, ECO:0000269|PubMed:19217779 source Swiss-Prot : SWS_FT_FI3 41) chain D residue 119 type BINDING sequence N description BINDING => ECO:0000269|PubMed:15513927, ECO:0000269|PubMed:17919905, ECO:0000269|PubMed:18069989, ECO:0000269|PubMed:18485702, ECO:0000269|PubMed:18553955, ECO:0000269|PubMed:19217779 source Swiss-Prot : SWS_FT_FI3 42) chain D residue 183 type BINDING sequence Y description BINDING => ECO:0000269|PubMed:15513927, ECO:0000269|PubMed:17919905, ECO:0000269|PubMed:18069989, ECO:0000269|PubMed:18485702, ECO:0000269|PubMed:18553955, ECO:0000269|PubMed:19217779 source Swiss-Prot : SWS_FT_FI3 43) chain D residue 218 type BINDING sequence I description BINDING => ECO:0000269|PubMed:15513927, ECO:0000269|PubMed:17919905, ECO:0000269|PubMed:18069989, ECO:0000269|PubMed:18485702, ECO:0000269|PubMed:18553955, ECO:0000269|PubMed:19217779 source Swiss-Prot : SWS_FT_FI3 44) chain D residue 170 type BINDING sequence S description BINDING => ECO:0000269|PubMed:15513927, ECO:0007744|PDB:1XU7, ECO:0007744|PDB:1XU9 source Swiss-Prot : SWS_FT_FI4 45) chain D residue 207 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000255 source Swiss-Prot : SWS_FT_FI6 46) chain D residue 123 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218 source Swiss-Prot : SWS_FT_FI5 47) chain D residue 162 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218 source Swiss-Prot : SWS_FT_FI5

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