eF-site ID 3hfg-ABCD PDB Code 3hfg Chain A, B, C, D click to enlarge Title Crystal Structure of Human 11-beta-hydroxysteroid-dehydrogenase Bound to an Sulfonyl-piperazine Inhibitor Classification OXIDOREDUCTASE Compound Corticosteroid 11-beta-dehydrogenase isozyme 1 Source Homo sapiens (Human) (DHI1_HUMAN) Sequence A:  EFRPEMLQGKKVIVTGASKGIGREMAYHLAKMGAHVVVTA RSKETLQKVVSHCLELGAASAHYIAGTMEDMTFAEQFVAQ AGKLMGGLDMLILNHITNTSLNLFHDDIHHVRKSMEVNFL SYVVLTVAALPMLKQSNGSIVVVSSLAGKVAYPMVAAYSA SKFALDGFFSSIRKEYSVSRVNVSITLCVLGLIDTETAMK AVSGIVHMQAAPKEECALEIIKGGALRQEEVYYDSSLWTT LLIRNPSRKILEFLYSTS B:  PLNEEFRPEMLQGKKVIVTGASKGIGREMAYHLAKMGAHV VVTARSKETLQKVVSHCLELGAASAHYIAGTMEDMTFAEQ FVAQAGKLMGGLDMLILNHITNTSLNLFHDDIHHVRKSME VNFLSYVVLTVAALPMLKQSNGSIVVVSSLAGKVAYPMVA AYSASKFALDGFFSSIRKEYSVSRVNVSITLCVLGLIDTE TAMKAVSGIHMQAAPKEECALEIIKGGALRQEEVYYDSSL WTTLLIRNPSRKILEFLYST C:  NEEFRPEMLQGKKVIVTGASKGIGREMAYHLAKMGAHVVV TARSKETLQKVVSHCLELGAASAHYIAGTMEDMTFAEQFV AQAGKLMGGLDMLILNHITNTSLNLFHDDIHHVRKSMEVN FLSYVVLTVAALPMLKQSNGSIVVVSSLAGKVAYPMVAAY SASKFALDGFFSSIRKEYSVSRVNVSITLCVLGLIDTETA MKAVSGIAAPKEECALEIIKGGALRQEEVYYDSSLWTTLL IRNPSRKILEFLYS D:  EEFRPEMLQGKKVIVTGASKGIGREMAYHLAKMGAHVVVT ARSKETLQKVVSHCLELGAASAHYIAGTMEDMTFAEQFVA QAGKLMGGLDMLILNHITNTSLNLFHDDIHHVRKSMEVNF LSYVVLTVAALPMLKQSNGSIVVVSSLAGKVAYPMVAAYS ASKFALDGFFSSIRKEYSVSRVNVSITLCVLGLIDTETAM KAVSGMQAAPKEECALEIIKGGALRQEEVYYDSSLWTTLL IRNPSRKILEFLYS Description Functional site 1) chain A residue 121 type sequence I description BINDING SITE FOR RESIDUE 17R A 1 source : AC1 2) chain A residue 124 type sequence T description BINDING SITE FOR RESIDUE 17R A 1 source : AC1 3) chain A residue 125 type sequence S description BINDING SITE FOR RESIDUE 17R A 1 source : AC1 4) chain A residue 126 type sequence L description BINDING SITE FOR RESIDUE 17R A 1 source : AC1 5) chain A residue 170 type sequence S description BINDING SITE FOR RESIDUE 17R A 1 source : AC1 6) chain A residue 171 type sequence L description BINDING SITE FOR RESIDUE 17R A 1 source : AC1 7) chain A residue 172 type sequence A description BINDING SITE FOR RESIDUE 17R A 1 source : AC1 8) chain A residue 177 type sequence Y description BINDING SITE FOR RESIDUE 17R A 1 source : AC1 9) chain A residue 178 type sequence P description BINDING SITE FOR RESIDUE 17R A 1 source : AC1 10) chain A residue 183 type sequence Y description BINDING SITE FOR RESIDUE 17R A 1 source : AC1 11) chain A residue 215 type sequence L description BINDING SITE FOR RESIDUE 17R A 1 source : AC1 12) chain A residue 216 type sequence G description BINDING SITE FOR RESIDUE 17R A 1 source : AC1 13) chain A residue 217 type sequence L description BINDING SITE FOR RESIDUE 17R A 1 source : AC1 14) chain A residue 222 type sequence T description BINDING SITE FOR RESIDUE 17R A 1 source : AC1 15) chain A residue 226 type sequence A description BINDING SITE FOR RESIDUE 17R A 1 source : AC1 16) chain A residue 227 type sequence V description BINDING SITE FOR RESIDUE 17R A 1 source : AC1 17) chain A residue 41 type sequence G description BINDING SITE FOR RESIDUE NAP A 293 source : AC2 18) chain A residue 43 type sequence S description BINDING SITE FOR RESIDUE NAP A 293 source : AC2 19) chain A residue 44 type sequence K description BINDING SITE FOR RESIDUE NAP A 293 source : AC2 20) chain A residue 45 type sequence G description BINDING SITE FOR RESIDUE NAP A 293 source : AC2 21) chain A residue 46 type sequence I description BINDING SITE FOR RESIDUE NAP A 293 source : AC2 22) chain A residue 65 type sequence A description BINDING SITE FOR RESIDUE NAP A 293 source : AC2 23) chain A residue 66 type sequence R description BINDING SITE FOR RESIDUE NAP A 293 source : AC2 24) chain A residue 67 type sequence S description BINDING SITE FOR RESIDUE NAP A 293 source : AC2 25) chain A residue 92 type sequence T description BINDING SITE FOR RESIDUE NAP A 293 source : AC2 26) chain A residue 93 type sequence M description BINDING SITE FOR RESIDUE NAP A 293 source : AC2 27) chain A residue 119 type sequence N description BINDING SITE FOR RESIDUE NAP A 293 source : AC2 28) chain A residue 120 type sequence H description BINDING SITE FOR RESIDUE NAP A 293 source : AC2 29) chain A residue 121 type sequence I description BINDING SITE FOR RESIDUE NAP A 293 source : AC2 30) chain A residue 168 type sequence V description BINDING SITE FOR RESIDUE NAP A 293 source : AC2 31) chain A residue 169 type sequence S description BINDING SITE FOR RESIDUE NAP A 293 source : AC2 32) chain A residue 170 type sequence S description BINDING SITE FOR RESIDUE NAP A 293 source : AC2 33) chain A residue 183 type sequence Y description BINDING SITE FOR RESIDUE NAP A 293 source : AC2 34) chain A residue 187 type sequence K description BINDING SITE FOR RESIDUE NAP A 293 source : AC2 35) chain A residue 215 type sequence L description BINDING SITE FOR RESIDUE NAP A 293 source : AC2 36) chain A residue 216 type sequence G description BINDING SITE FOR RESIDUE NAP A 293 source : AC2 37) chain A residue 218 type sequence I description BINDING SITE FOR RESIDUE NAP A 293 source : AC2 38) chain A residue 220 type sequence T description BINDING SITE FOR RESIDUE NAP A 293 source : AC2 39) chain A residue 222 type sequence T description BINDING SITE FOR RESIDUE NAP A 293 source : AC2 40) chain A residue 223 type sequence A description BINDING SITE FOR RESIDUE NAP A 293 source : AC2 41) chain A residue 280 type sequence Y description BINDING SITE FOR RESIDUE 17R B 1 source : AC3 42) chain B residue 125 type sequence S description BINDING SITE FOR RESIDUE 17R B 1 source : AC3 43) chain B residue 126 type sequence L description BINDING SITE FOR RESIDUE 17R B 1 source : AC3 44) chain B residue 170 type sequence S description BINDING SITE FOR RESIDUE 17R B 1 source : AC3 45) chain B residue 171 type sequence L description BINDING SITE FOR RESIDUE 17R B 1 source : AC3 46) chain B residue 172 type sequence A description BINDING SITE FOR RESIDUE 17R B 1 source : AC3 47) chain B residue 177 type sequence Y description BINDING SITE FOR RESIDUE 17R B 1 source : AC3 48) chain B residue 178 type sequence P description BINDING SITE FOR RESIDUE 17R B 1 source : AC3 49) chain B residue 183 type sequence Y description BINDING SITE FOR RESIDUE 17R B 1 source : AC3 50) chain B residue 215 type sequence L description BINDING SITE FOR RESIDUE 17R B 1 source : AC3 51) chain B residue 216 type sequence G description BINDING SITE FOR RESIDUE 17R B 1 source : AC3 52) chain B residue 217 type sequence L description BINDING SITE FOR RESIDUE 17R B 1 source : AC3 53) chain B residue 222 type sequence T description BINDING SITE FOR RESIDUE 17R B 1 source : AC3 54) chain B residue 226 type sequence A description BINDING SITE FOR RESIDUE 17R B 1 source : AC3 55) chain B residue 233 type sequence M description BINDING SITE FOR RESIDUE 17R B 1 source : AC3 56) chain B residue 41 type sequence G description BINDING SITE FOR RESIDUE NAP B 293 source : AC4 57) chain B residue 43 type sequence S description BINDING SITE FOR RESIDUE NAP B 293 source : AC4 58) chain B residue 44 type sequence K description BINDING SITE FOR RESIDUE NAP B 293 source : AC4 59) chain B residue 45 type sequence G description BINDING SITE FOR RESIDUE NAP B 293 source : AC4 60) chain B residue 46 type sequence I description BINDING SITE FOR RESIDUE NAP B 293 source : AC4 61) chain B residue 65 type sequence A description BINDING SITE FOR RESIDUE NAP B 293 source : AC4 62) chain B residue 66 type sequence R description BINDING SITE FOR RESIDUE NAP B 293 source : AC4 63) chain B residue 67 type sequence S description BINDING SITE FOR RESIDUE NAP B 293 source : AC4 64) chain B residue 92 type sequence T description BINDING SITE FOR RESIDUE NAP B 293 source : AC4 65) chain B residue 93 type sequence M description BINDING SITE FOR RESIDUE NAP B 293 source : AC4 66) chain B residue 119 type sequence N description BINDING SITE FOR RESIDUE NAP B 293 source : AC4 67) chain B residue 121 type sequence I description BINDING SITE FOR RESIDUE NAP B 293 source : AC4 68) chain B residue 168 type sequence V description BINDING SITE FOR RESIDUE NAP B 293 source : AC4 69) chain B residue 169 type sequence S description BINDING SITE FOR RESIDUE NAP B 293 source : AC4 70) chain B residue 170 type sequence S description BINDING SITE FOR RESIDUE NAP B 293 source : AC4 71) chain B residue 183 type sequence Y description BINDING SITE FOR RESIDUE NAP B 293 source : AC4 72) chain B residue 187 type sequence K description BINDING SITE FOR RESIDUE NAP B 293 source : AC4 73) chain B residue 215 type sequence L description BINDING SITE FOR RESIDUE NAP B 293 source : AC4 74) chain B residue 216 type sequence G description BINDING SITE FOR RESIDUE NAP B 293 source : AC4 75) chain B residue 217 type sequence L description BINDING SITE FOR RESIDUE NAP B 293 source : AC4 76) chain B residue 218 type sequence I description BINDING SITE FOR RESIDUE NAP B 293 source : AC4 77) chain B residue 220 type sequence T description BINDING SITE FOR RESIDUE NAP B 293 source : AC4 78) chain B residue 222 type sequence T description BINDING SITE FOR RESIDUE NAP B 293 source : AC4 79) chain B residue 223 type sequence A description BINDING SITE FOR RESIDUE NAP B 293 source : AC4 80) chain C residue 121 type sequence I description BINDING SITE FOR RESIDUE 17R C 1 source : AC5 81) chain C residue 125 type sequence S description BINDING SITE FOR RESIDUE 17R C 1 source : AC5 82) chain C residue 126 type sequence L description BINDING SITE FOR RESIDUE 17R C 1 source : AC5 83) chain C residue 170 type sequence S description BINDING SITE FOR RESIDUE 17R C 1 source : AC5 84) chain C residue 171 type sequence L description BINDING SITE FOR RESIDUE 17R C 1 source : AC5 85) chain C residue 172 type sequence A description BINDING SITE FOR RESIDUE 17R C 1 source : AC5 86) chain C residue 177 type sequence Y description BINDING SITE FOR RESIDUE 17R C 1 source : AC5 87) chain C residue 178 type sequence P description BINDING SITE FOR RESIDUE 17R C 1 source : AC5 88) chain C residue 183 type sequence Y description BINDING SITE FOR RESIDUE 17R C 1 source : AC5 89) chain C residue 215 type sequence L description BINDING SITE FOR RESIDUE 17R C 1 source : AC5 90) chain C residue 216 type sequence G description BINDING SITE FOR RESIDUE 17R C 1 source : AC5 91) chain C residue 217 type sequence L description BINDING SITE FOR RESIDUE 17R C 1 source : AC5 92) chain C residue 222 type sequence T description BINDING SITE FOR RESIDUE 17R C 1 source : AC5 93) chain C residue 226 type sequence A description BINDING SITE FOR RESIDUE 17R C 1 source : AC5 94) chain D residue 280 type sequence Y description BINDING SITE FOR RESIDUE 17R C 1 source : AC5 95) chain C residue 41 type sequence G description BINDING SITE FOR RESIDUE NAP C 293 source : AC6 96) chain C residue 43 type sequence S description BINDING SITE FOR RESIDUE NAP C 293 source : AC6 97) chain C residue 44 type sequence K description BINDING SITE FOR RESIDUE NAP C 293 source : AC6 98) chain C residue 46 type sequence I description BINDING SITE FOR RESIDUE NAP C 293 source : AC6 99) chain C residue 66 type sequence R description BINDING SITE FOR RESIDUE NAP C 293 source : AC6 100) chain C residue 67 type sequence S description BINDING SITE FOR RESIDUE NAP C 293 source : AC6 101) chain C residue 92 type sequence T description BINDING SITE FOR RESIDUE NAP C 293 source : AC6 102) chain C residue 93 type sequence M description BINDING SITE FOR RESIDUE NAP C 293 source : AC6 103) chain C residue 119 type sequence N description BINDING SITE FOR RESIDUE NAP C 293 source : AC6 104) chain C residue 120 type sequence H description BINDING SITE FOR RESIDUE NAP C 293 source : AC6 105) chain C residue 121 type sequence I description BINDING SITE FOR RESIDUE NAP C 293 source : AC6 106) chain C residue 168 type sequence V description BINDING SITE FOR RESIDUE NAP C 293 source : AC6 107) chain C residue 169 type sequence S description BINDING SITE FOR RESIDUE NAP C 293 source : AC6 108) chain C residue 170 type sequence S description BINDING SITE FOR RESIDUE NAP C 293 source : AC6 109) chain C residue 183 type sequence Y description BINDING SITE FOR RESIDUE NAP C 293 source : AC6 110) chain C residue 187 type sequence K description BINDING SITE FOR RESIDUE NAP C 293 source : AC6 111) chain C residue 215 type sequence L description BINDING SITE FOR RESIDUE NAP C 293 source : AC6 112) chain C residue 216 type sequence G description BINDING SITE FOR RESIDUE NAP C 293 source : AC6 113) chain C residue 218 type sequence I description BINDING SITE FOR RESIDUE NAP C 293 source : AC6 114) chain C residue 220 type sequence T description BINDING SITE FOR RESIDUE NAP C 293 source : AC6 115) chain C residue 222 type sequence T description BINDING SITE FOR RESIDUE NAP C 293 source : AC6 116) chain C residue 223 type sequence A description BINDING SITE FOR RESIDUE NAP C 293 source : AC6 117) chain D residue 121 type sequence I description BINDING SITE FOR RESIDUE 17R D 1 source : AC7 118) chain D residue 126 type sequence L description BINDING SITE FOR RESIDUE 17R D 1 source : AC7 119) chain D residue 170 type sequence S description BINDING SITE FOR RESIDUE 17R D 1 source : AC7 120) chain D residue 171 type sequence L description BINDING SITE FOR RESIDUE 17R D 1 source : AC7 121) chain D residue 172 type sequence A description BINDING SITE FOR RESIDUE 17R D 1 source : AC7 122) chain D residue 177 type sequence Y description BINDING SITE FOR RESIDUE 17R D 1 source : AC7 123) chain D residue 178 type sequence P description BINDING SITE FOR RESIDUE 17R D 1 source : AC7 124) chain D residue 183 type sequence Y description BINDING SITE FOR RESIDUE 17R D 1 source : AC7 125) chain D residue 216 type sequence G description BINDING SITE FOR RESIDUE 17R D 1 source : AC7 126) chain D residue 217 type sequence L description BINDING SITE FOR RESIDUE 17R D 1 source : AC7 127) chain D residue 222 type sequence T description BINDING SITE FOR RESIDUE 17R D 1 source : AC7 128) chain D residue 226 type sequence A description BINDING SITE FOR RESIDUE 17R D 1 source : AC7 129) chain D residue 41 type sequence G description BINDING SITE FOR RESIDUE NAP D 293 source : AC8 130) chain D residue 42 type sequence A description BINDING SITE FOR RESIDUE NAP D 293 source : AC8 131) chain D residue 43 type sequence S description BINDING SITE FOR RESIDUE NAP D 293 source : AC8 132) chain D residue 44 type sequence K description BINDING SITE FOR RESIDUE NAP D 293 source : AC8 133) chain D residue 45 type sequence G description BINDING SITE FOR RESIDUE NAP D 293 source : AC8 134) chain D residue 46 type sequence I description BINDING SITE FOR RESIDUE NAP D 293 source : AC8 135) chain D residue 65 type sequence A description BINDING SITE FOR RESIDUE NAP D 293 source : AC8 136) chain D residue 66 type sequence R description BINDING SITE FOR RESIDUE NAP D 293 source : AC8 137) chain D residue 67 type sequence S description BINDING SITE FOR RESIDUE NAP D 293 source : AC8 138) chain D residue 92 type sequence T description BINDING SITE FOR RESIDUE NAP D 293 source : AC8 139) chain D residue 93 type sequence M description BINDING SITE FOR RESIDUE NAP D 293 source : AC8 140) chain D residue 119 type sequence N description BINDING SITE FOR RESIDUE NAP D 293 source : AC8 141) chain D residue 120 type sequence H description BINDING SITE FOR RESIDUE NAP D 293 source : AC8 142) chain D residue 121 type sequence I description BINDING SITE FOR RESIDUE NAP D 293 source : AC8 143) chain D residue 168 type sequence V description BINDING SITE FOR RESIDUE NAP D 293 source : AC8 144) chain D residue 169 type sequence S description BINDING SITE FOR RESIDUE NAP D 293 source : AC8 145) chain D residue 170 type sequence S description BINDING SITE FOR RESIDUE NAP D 293 source : AC8 146) chain D residue 183 type sequence Y description BINDING SITE FOR RESIDUE NAP D 293 source : AC8 147) chain D residue 187 type sequence K description BINDING SITE FOR RESIDUE NAP D 293 source : AC8 148) chain D residue 216 type sequence G description BINDING SITE FOR RESIDUE NAP D 293 source : AC8 149) chain D residue 218 type sequence I description BINDING SITE FOR RESIDUE NAP D 293 source : AC8 150) chain D residue 220 type sequence T description BINDING SITE FOR RESIDUE NAP D 293 source : AC8 151) chain D residue 222 type sequence T description BINDING SITE FOR RESIDUE NAP D 293 source : AC8 152) chain D residue 223 type sequence A description BINDING SITE FOR RESIDUE NAP D 293 source : AC8 153) chain A residue 183 type ACT_SITE sequence Y description Proton acceptor source Swiss-Prot : SWS_FT_FI2 154) chain B residue 183 type ACT_SITE sequence Y description Proton acceptor source Swiss-Prot : SWS_FT_FI2 155) chain C residue 183 type ACT_SITE sequence Y description Proton acceptor source Swiss-Prot : SWS_FT_FI2 156) chain D residue 183 type ACT_SITE sequence Y description Proton acceptor source Swiss-Prot : SWS_FT_FI2 157) chain A residue 41 type BINDING sequence G description BINDING => ECO:0000269|PubMed:15513927, ECO:0000269|PubMed:17919905, ECO:0000269|PubMed:18069989, ECO:0000269|PubMed:18485702, ECO:0000269|PubMed:18553955, ECO:0000269|PubMed:19217779 source Swiss-Prot : SWS_FT_FI3 158) chain B residue 218 type BINDING sequence I description BINDING => ECO:0000269|PubMed:15513927, ECO:0000269|PubMed:17919905, ECO:0000269|PubMed:18069989, ECO:0000269|PubMed:18485702, ECO:0000269|PubMed:18553955, ECO:0000269|PubMed:19217779 source Swiss-Prot : SWS_FT_FI3 159) chain C residue 41 type BINDING sequence G description BINDING => ECO:0000269|PubMed:15513927, ECO:0000269|PubMed:17919905, ECO:0000269|PubMed:18069989, ECO:0000269|PubMed:18485702, ECO:0000269|PubMed:18553955, ECO:0000269|PubMed:19217779 source Swiss-Prot : SWS_FT_FI3 160) chain C residue 92 type BINDING sequence T description BINDING => ECO:0000269|PubMed:15513927, ECO:0000269|PubMed:17919905, ECO:0000269|PubMed:18069989, ECO:0000269|PubMed:18485702, ECO:0000269|PubMed:18553955, ECO:0000269|PubMed:19217779 source Swiss-Prot : SWS_FT_FI3 161) chain C residue 119 type BINDING sequence N description BINDING => ECO:0000269|PubMed:15513927, ECO:0000269|PubMed:17919905, ECO:0000269|PubMed:18069989, ECO:0000269|PubMed:18485702, ECO:0000269|PubMed:18553955, ECO:0000269|PubMed:19217779 source Swiss-Prot : SWS_FT_FI3 162) chain C residue 183 type BINDING sequence Y description BINDING => ECO:0000269|PubMed:15513927, ECO:0000269|PubMed:17919905, ECO:0000269|PubMed:18069989, ECO:0000269|PubMed:18485702, ECO:0000269|PubMed:18553955, ECO:0000269|PubMed:19217779 source Swiss-Prot : SWS_FT_FI3 163) chain C residue 218 type BINDING sequence I description BINDING => ECO:0000269|PubMed:15513927, ECO:0000269|PubMed:17919905, ECO:0000269|PubMed:18069989, ECO:0000269|PubMed:18485702, ECO:0000269|PubMed:18553955, ECO:0000269|PubMed:19217779 source Swiss-Prot : SWS_FT_FI3 164) chain D residue 41 type BINDING sequence G description BINDING => ECO:0000269|PubMed:15513927, ECO:0000269|PubMed:17919905, ECO:0000269|PubMed:18069989, ECO:0000269|PubMed:18485702, ECO:0000269|PubMed:18553955, ECO:0000269|PubMed:19217779 source Swiss-Prot : SWS_FT_FI3 165) chain D residue 92 type BINDING sequence T description BINDING => ECO:0000269|PubMed:15513927, ECO:0000269|PubMed:17919905, ECO:0000269|PubMed:18069989, ECO:0000269|PubMed:18485702, ECO:0000269|PubMed:18553955, ECO:0000269|PubMed:19217779 source Swiss-Prot : SWS_FT_FI3 166) chain D residue 119 type BINDING sequence N description BINDING => ECO:0000269|PubMed:15513927, ECO:0000269|PubMed:17919905, ECO:0000269|PubMed:18069989, ECO:0000269|PubMed:18485702, ECO:0000269|PubMed:18553955, ECO:0000269|PubMed:19217779 source Swiss-Prot : SWS_FT_FI3 167) chain D residue 183 type BINDING sequence Y description BINDING => ECO:0000269|PubMed:15513927, ECO:0000269|PubMed:17919905, ECO:0000269|PubMed:18069989, ECO:0000269|PubMed:18485702, ECO:0000269|PubMed:18553955, ECO:0000269|PubMed:19217779 source Swiss-Prot : SWS_FT_FI3 168) chain A residue 92 type BINDING sequence T description BINDING => ECO:0000269|PubMed:15513927, ECO:0000269|PubMed:17919905, ECO:0000269|PubMed:18069989, ECO:0000269|PubMed:18485702, ECO:0000269|PubMed:18553955, ECO:0000269|PubMed:19217779 source Swiss-Prot : SWS_FT_FI3 169) chain D residue 218 type BINDING sequence I description BINDING => ECO:0000269|PubMed:15513927, ECO:0000269|PubMed:17919905, ECO:0000269|PubMed:18069989, ECO:0000269|PubMed:18485702, ECO:0000269|PubMed:18553955, ECO:0000269|PubMed:19217779 source Swiss-Prot : SWS_FT_FI3 170) chain A residue 119 type BINDING sequence N description BINDING => ECO:0000269|PubMed:15513927, ECO:0000269|PubMed:17919905, ECO:0000269|PubMed:18069989, ECO:0000269|PubMed:18485702, ECO:0000269|PubMed:18553955, ECO:0000269|PubMed:19217779 source Swiss-Prot : SWS_FT_FI3 171) chain A residue 183 type BINDING sequence Y description BINDING => ECO:0000269|PubMed:15513927, ECO:0000269|PubMed:17919905, ECO:0000269|PubMed:18069989, ECO:0000269|PubMed:18485702, ECO:0000269|PubMed:18553955, ECO:0000269|PubMed:19217779 source Swiss-Prot : SWS_FT_FI3 172) chain A residue 218 type BINDING sequence I description BINDING => ECO:0000269|PubMed:15513927, ECO:0000269|PubMed:17919905, ECO:0000269|PubMed:18069989, ECO:0000269|PubMed:18485702, ECO:0000269|PubMed:18553955, ECO:0000269|PubMed:19217779 source Swiss-Prot : SWS_FT_FI3 173) chain B residue 41 type BINDING sequence G description BINDING => ECO:0000269|PubMed:15513927, ECO:0000269|PubMed:17919905, ECO:0000269|PubMed:18069989, ECO:0000269|PubMed:18485702, ECO:0000269|PubMed:18553955, ECO:0000269|PubMed:19217779 source Swiss-Prot : SWS_FT_FI3 174) chain B residue 92 type BINDING sequence T description BINDING => ECO:0000269|PubMed:15513927, ECO:0000269|PubMed:17919905, ECO:0000269|PubMed:18069989, ECO:0000269|PubMed:18485702, ECO:0000269|PubMed:18553955, ECO:0000269|PubMed:19217779 source Swiss-Prot : SWS_FT_FI3 175) chain B residue 119 type BINDING sequence N description BINDING => ECO:0000269|PubMed:15513927, ECO:0000269|PubMed:17919905, ECO:0000269|PubMed:18069989, ECO:0000269|PubMed:18485702, ECO:0000269|PubMed:18553955, ECO:0000269|PubMed:19217779 source Swiss-Prot : SWS_FT_FI3 176) chain B residue 183 type BINDING sequence Y description BINDING => ECO:0000269|PubMed:15513927, ECO:0000269|PubMed:17919905, ECO:0000269|PubMed:18069989, ECO:0000269|PubMed:18485702, ECO:0000269|PubMed:18553955, ECO:0000269|PubMed:19217779 source Swiss-Prot : SWS_FT_FI3 177) chain A residue 170 type BINDING sequence S description BINDING => ECO:0000269|PubMed:15513927, ECO:0007744|PDB:1XU7, ECO:0007744|PDB:1XU9 source Swiss-Prot : SWS_FT_FI4 178) chain B residue 170 type BINDING sequence S description BINDING => ECO:0000269|PubMed:15513927, ECO:0007744|PDB:1XU7, ECO:0007744|PDB:1XU9 source Swiss-Prot : SWS_FT_FI4 179) chain C residue 170 type BINDING sequence S description BINDING => ECO:0000269|PubMed:15513927, ECO:0007744|PDB:1XU7, ECO:0007744|PDB:1XU9 source Swiss-Prot : SWS_FT_FI4 180) chain D residue 170 type BINDING sequence S description BINDING => ECO:0000269|PubMed:15513927, ECO:0007744|PDB:1XU7, ECO:0007744|PDB:1XU9 source Swiss-Prot : SWS_FT_FI4 181) chain A residue 207 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000255 source Swiss-Prot : SWS_FT_FI6 182) chain B residue 207 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000255 source Swiss-Prot : SWS_FT_FI6 183) chain C residue 207 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000255 source Swiss-Prot : SWS_FT_FI6 184) chain D residue 207 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000255 source Swiss-Prot : SWS_FT_FI6 185) chain A residue 123 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218 source Swiss-Prot : SWS_FT_FI5 186) chain A residue 162 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218 source Swiss-Prot : SWS_FT_FI5 187) chain B residue 123 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218 source Swiss-Prot : SWS_FT_FI5 188) chain B residue 162 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218 source Swiss-Prot : SWS_FT_FI5 189) chain C residue 123 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218 source Swiss-Prot : SWS_FT_FI5 190) chain C residue 162 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218 source Swiss-Prot : SWS_FT_FI5 191) chain D residue 123 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218 source Swiss-Prot : SWS_FT_FI5 192) chain D residue 162 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218 source Swiss-Prot : SWS_FT_FI5 193) chain A residue 170-198 type prosite sequence SLAGKVAYPMVAAYSASKFALDGFFSSIR description ADH_SHORT Short-chain dehydrogenases/reductases family signature. SlagkvaypmVaaYSASKFALdGFFsSIR source prosite : PS00061

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