eF-site ID 3hei-ABCDEFGHIJKLMNOP PDB Code 3hei Chain A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P click to enlarge Title Ligand Recognition by A-Class Eph Receptors: Crystal Structures of the EphA2 Ligand-Binding Domain and the EphA2/ephrin-A1 Complex Classification TRANSFERASE/SIGNALING PROTEIN Compound Ephrin type-A receptor 2 Source Homo sapiens (Human) (EFNA1_HUMAN) Sequence A:  EVVLLDFAAAGGELGWLTHPYGKGWDLMQNIMNDMPIYMY SVCNVMSGDQDNWLRTNWVYRGEAERIFIELKFTVRDCNS FPGGASSCKETFNLYYAESDLDYGTNFQKRLFTKIDTIAP DEITVSSDFEARHVKLNVEERSVGPLTRKGFYLAFQDIGA CVALLSVRVYYKKC B:  ADRHTVFWNSSNPKFRNEDYTIHVQLNDYVDIICPHYEDH SVADAAMEQYILYLVEHEEYQLCQPQSKDQVRWQCNRPSA KHGPEKLSEKFQRFTPFTLGKEFKEGHSYYYISKPIHQHE DRCLRLKVTVKI C:  EVVLLDFAAAGGELGWLTHPYGKGWDLMQNIMNDMPIYMY SVCNVMSGDQDNWLRTNWVYRGEAERIFIELKFTVRDCNS FPGGASSCKETFNLYYAESDLDYGTNFQKRLFTKIDTIAP DEITVSSDFEARHVKLNVEERSVGPLTRKGFYLAFQDIGA CVALLSVRVYYKKC D:  ADRHTVFWNSSNPKFRNEDYTIHVQLNDYVDIICPHYEDH SVADAAMEQYILYLVEHEEYQLCQPQSKDQVRWQCNRPSA KHGPEKLSEKFQRFTPFTLGKEFKEGHSYYYISKPIHQHE DRCLRLKVTVKI E:  EVVLLDFAAAGGELGWLTHPYGKGWDLMQNIMNDMPIYMY SVCNVMSGDQDNWLRTNWVYRGEAERIFIELKFTVRDCNS FPGGASSCKETFNLYYAESDLDYGTNFQKRLFTKIDTIAP DEITVSSDFEARHVKLNVEERSVGPLTRKGFYLAFQDIGA CVALLSVRVYYKKC F:  ADRHTVFWNSSNPKFRNEDYTIHVQLNDYVDIICPHYEDH SVADAAMEQYILYLVEHEEYQLCQPQSKDQVRWQCNRPSA KHGPEKLSEKFQRFTPFTLGKEFKEGHSYYYISKPIHQHE DRCLRLKVTVKI G:  EVVLLDFAAAGGELGWLTHPYGKGWDLMQNIMNDMPIYMY SVCNVMSGDQDNWLRTNWVYRGEAERIFIELKFTVRDCNS FPGGASSCKETFNLYYAESDLDYGTNFQKRLFTKIDTIAP DEITVSSDFEARHVKLNVEERSVGPLTRKGFYLAFQDIGA CVALLSVRVYYKKC H:  ADRHTVFWNSSNPKFRNEDYTIHVQLNDYVDIICPHYEDH SVADAAMEQYILYLVEHEEYQLCQPQSKDQVRWQCNRPSA KHGPEKLSEKFQRFTPFTLGKEFKEGHSYYYISKPIHQHE DRCLRLKVTVKI I:  EVVLLDFAAAGGELGWLTHPYGKGWDLMQNIMNDMPIYMY SVCNVMSGDQDNWLRTNWVYRGEAERIFIELKFTVRDCNS FPGGASSCKETFNLYYAESDLDYGTNFQKRLFTKIDTIAP DEITVSSDFEARHVKLNVEERSVGPLTRKGFYLAFQDIGA CVALLSVRVYYKKC J:  ADRHTVFWNSSNPKFRNEDYTIHVQLNDYVDIICPHYEDH SVADAAMEQYILYLVEHEEYQLCQPQSKDQVRWQCNRPSA KHGPEKLSEKFQRFTPFTLGKEFKEGHSYYYISKPIHQHE DRCLRLKVTVKI K:  EVVLLDFAAAGGELGWLTHPYGKGWDLMQNIMNDMPIYMY SVCNVMSGDQDNWLRTNWVYRGEAERIFIELKFTVRDCNS FPGGASSCKETFNLYYAESDLDYGTNFQKRLFTKIDTIAP DEITVSSDFEARHVKLNVEERSVGPLTRKGFYLAFQDIGA CVALLSVRVYYKKC L:  ADRHTVFWNSSNPKFRNEDYTIHVQLNDYVDIICPHYEDH SVADAAMEQYILYLVEHEEYQLCQPQSKDQVRWQCNRPSA KHGPEKLSEKFQRFTPFTLGKEFKEGHSYYYISKPIHQHE DRCLRLKVTVKI M:  EVVLLDFAAAGGELGWLTHPYGKGWDLMQNIMNDMPIYMY SVCNVMSGDQDNWLRTNWVYRGEAERIFIELKFTVRDCNS FPGGASSCKETFNLYYAESDLDYGTNFQKRLFTKIDTIAP DEITVSSDFEARHVKLNVEERSVGPLTRKGFYLAFQDIGA CVALLSVRVYYKKC N:  ADRHTVFWNSSNPKFRNEDYTIHVQLNDYVDIICPHYEDH SVADAAMEQYILYLVEHEEYQLCQPQSKDQVRWQCNRPSA KHGPEKLSEKFQRFTPFTLGKEFKEGHSYYYISKPIHQHE DRCLRLKVTVKI O:  EVVLLDFAAAGGELGWLTHPYGKGWDLMQNIMNDMPIYMY SVCNVMSGDQDNWLRTNWVYRGEAERIFIELKFTVRDCNS FPGGASSCKETFNLYYAESDLDYGTNFQKRLFTKIDTIAP DEITVSSDFEARHVKLNVEERSVGPLTRKGFYLAFQDIGA CVALLSVRVYYKKC P:  ADRHTVFWNSSNPKFRNEDYTIHVQLNDYVDIICPHYEDH SVADAAMEQYILYLVEHEEYQLCQPQSKDQVRWQCNRPSA KHGPEKLSEKFQRFTPFTLGKEFKEGHSYYYISKPIHQHE DRCLRLKVTVKI Description (1)  Ephrin type-A receptor 2 (E.C.2.7.10.1), Ephrin-A1 Functional site 1) chain B residue 103-130 type prosite sequence KLSEKFQRFTPFTLGKEFKEGHSYYYIS description EPHRIN_RBD_1 Ephrin receptor-binding (ephrin RBD) domain signature. KLSeKFQrFTPftlGkEFkeghsYYyiS source prosite : PS01299 2) chain B residue 26 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:20505120, ECO:0000269|PubMed:23661698 source Swiss-Prot : SWS_FT_FI1 3) chain D residue 26 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:20505120, ECO:0000269|PubMed:23661698 source Swiss-Prot : SWS_FT_FI1 4) chain F residue 26 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:20505120, ECO:0000269|PubMed:23661698 source Swiss-Prot : SWS_FT_FI1 5) chain H residue 26 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:20505120, ECO:0000269|PubMed:23661698 source Swiss-Prot : SWS_FT_FI1 6) chain J residue 26 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:20505120, ECO:0000269|PubMed:23661698 source Swiss-Prot : SWS_FT_FI1 7) chain L residue 26 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:20505120, ECO:0000269|PubMed:23661698 source Swiss-Prot : SWS_FT_FI1 8) chain N residue 26 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:20505120, ECO:0000269|PubMed:23661698 source Swiss-Prot : SWS_FT_FI1 9) chain P residue 26 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:20505120, ECO:0000269|PubMed:23661698 source Swiss-Prot : SWS_FT_FI1

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