eF-site ID 3hcm-AB PDB Code 3hcm Chain A, B click to enlarge Title Crystal structure of human S100B in complex with S45 Classification METAL BINDING PROTEIN Compound Protein S100-B Source Homo sapiens (Human) (S100B_HUMAN) Sequence A:  MSELEKAMVALIDVFHQYSGREGDKHKLKKSELKELINNE LSHFLEEIKEQEVVDKVMETLDNDGDGECDFQEFMAFVAM VTTACHEFFE B:  MSELEKAMVALIDVFHQYSGREGDKHKLKKSELKELINNE LSHFLEEIKEQEVVDKVMETLDNDGDGECDFQEFMAFVAM VTTACHEFFEH Description Functional site 1) chain A residue 18 type sequence S description BINDING SITE FOR RESIDUE CA A 92 source : AC1 2) chain A residue 21 type sequence E description BINDING SITE FOR RESIDUE CA A 92 source : AC1 3) chain A residue 23 type sequence D description BINDING SITE FOR RESIDUE CA A 92 source : AC1 4) chain A residue 26 type sequence K description BINDING SITE FOR RESIDUE CA A 92 source : AC1 5) chain A residue 31 type sequence E description BINDING SITE FOR RESIDUE CA A 92 source : AC1 6) chain A residue 61 type sequence D description BINDING SITE FOR RESIDUE CA A 93 source : AC2 7) chain A residue 63 type sequence D description BINDING SITE FOR RESIDUE CA A 93 source : AC2 8) chain A residue 65 type sequence D description BINDING SITE FOR RESIDUE CA A 93 source : AC2 9) chain A residue 67 type sequence E description BINDING SITE FOR RESIDUE CA A 93 source : AC2 10) chain A residue 72 type sequence E description BINDING SITE FOR RESIDUE CA A 93 source : AC2 11) chain A residue 44 type sequence L description BINDING SITE FOR RESIDUE S45 A 94 source : AC3 12) chain A residue 60 type sequence L description BINDING SITE FOR RESIDUE S45 A 94 source : AC3 13) chain A residue 76 type sequence F description BINDING SITE FOR RESIDUE S45 A 94 source : AC3 14) chain A residue 79 type sequence M description BINDING SITE FOR RESIDUE S45 A 94 source : AC3 15) chain A residue 45 type sequence E description BINDING SITE FOR RESIDUE ACT A 95 source : AC4 16) chain B residue 18 type sequence S description BINDING SITE FOR RESIDUE CA B 92 source : AC5 17) chain B residue 21 type sequence E description BINDING SITE FOR RESIDUE CA B 92 source : AC5 18) chain B residue 23 type sequence D description BINDING SITE FOR RESIDUE CA B 92 source : AC5 19) chain B residue 26 type sequence K description BINDING SITE FOR RESIDUE CA B 92 source : AC5 20) chain B residue 31 type sequence E description BINDING SITE FOR RESIDUE CA B 92 source : AC5 21) chain B residue 61 type sequence D description BINDING SITE FOR RESIDUE CA B 93 source : AC6 22) chain B residue 63 type sequence D description BINDING SITE FOR RESIDUE CA B 93 source : AC6 23) chain B residue 65 type sequence D description BINDING SITE FOR RESIDUE CA B 93 source : AC6 24) chain B residue 67 type sequence E description BINDING SITE FOR RESIDUE CA B 93 source : AC6 25) chain B residue 72 type sequence E description BINDING SITE FOR RESIDUE CA B 93 source : AC6 26) chain B residue 44 type sequence L description BINDING SITE FOR RESIDUE S45 B 94 source : AC7 27) chain B residue 45 type sequence E description BINDING SITE FOR RESIDUE S45 B 94 source : AC7 28) chain B residue 56 type sequence V description BINDING SITE FOR RESIDUE S45 B 94 source : AC7 29) chain B residue 76 type sequence F description BINDING SITE FOR RESIDUE S45 B 94 source : AC7 30) chain B residue 79 type sequence M description BINDING SITE FOR RESIDUE S45 B 94 source : AC7 31) chain A residue 63 type BINDING sequence D description BINDING => ECO:0000255|PROSITE-ProRule:PRU00448, ECO:0000269|PubMed:20950652, ECO:0007744|PDB:2H61, ECO:0007744|PDB:3CZT, ECO:0007744|PDB:3D0Y, ECO:0007744|PDB:3D10 source Swiss-Prot : SWS_FT_FI4 32) chain B residue 63 type BINDING sequence D description BINDING => ECO:0000255|PROSITE-ProRule:PRU00448, ECO:0000269|PubMed:20950652, ECO:0007744|PDB:2H61, ECO:0007744|PDB:3CZT, ECO:0007744|PDB:3D0Y, ECO:0007744|PDB:3D10 source Swiss-Prot : SWS_FT_FI4 33) chain A residue 1 type MOD_RES sequence S description N-acetylserine; alternate => ECO:0000250|UniProtKB:P02638 source Swiss-Prot : SWS_FT_FI5 34) chain B residue 1 type MOD_RES sequence S description N-acetylserine; alternate => ECO:0000250|UniProtKB:P02638 source Swiss-Prot : SWS_FT_FI5 35) chain A residue 61 type BINDING sequence D description BINDING => ECO:0000255|PROSITE-ProRule:PRU00448, ECO:0000269|PubMed:20950652, ECO:0007744|PDB:3CZT, ECO:0007744|PDB:3D0Y, ECO:0007744|PDB:3D10 source Swiss-Prot : SWS_FT_FI3 36) chain A residue 65 type BINDING sequence D description BINDING => ECO:0000255|PROSITE-ProRule:PRU00448, ECO:0000269|PubMed:20950652, ECO:0007744|PDB:3CZT, ECO:0007744|PDB:3D0Y, ECO:0007744|PDB:3D10 source Swiss-Prot : SWS_FT_FI3 37) chain A residue 67 type BINDING sequence E description BINDING => ECO:0000255|PROSITE-ProRule:PRU00448, ECO:0000269|PubMed:20950652, ECO:0007744|PDB:3CZT, ECO:0007744|PDB:3D0Y, ECO:0007744|PDB:3D10 source Swiss-Prot : SWS_FT_FI3 38) chain A residue 72 type BINDING sequence E description BINDING => ECO:0000255|PROSITE-ProRule:PRU00448, ECO:0000269|PubMed:20950652, ECO:0007744|PDB:3CZT, ECO:0007744|PDB:3D0Y, ECO:0007744|PDB:3D10 source Swiss-Prot : SWS_FT_FI3 39) chain B residue 61 type BINDING sequence D description BINDING => ECO:0000255|PROSITE-ProRule:PRU00448, ECO:0000269|PubMed:20950652, ECO:0007744|PDB:3CZT, ECO:0007744|PDB:3D0Y, ECO:0007744|PDB:3D10 source Swiss-Prot : SWS_FT_FI3 40) chain B residue 65 type BINDING sequence D description BINDING => ECO:0000255|PROSITE-ProRule:PRU00448, ECO:0000269|PubMed:20950652, ECO:0007744|PDB:3CZT, ECO:0007744|PDB:3D0Y, ECO:0007744|PDB:3D10 source Swiss-Prot : SWS_FT_FI3 41) chain B residue 67 type BINDING sequence E description BINDING => ECO:0000255|PROSITE-ProRule:PRU00448, ECO:0000269|PubMed:20950652, ECO:0007744|PDB:3CZT, ECO:0007744|PDB:3D0Y, ECO:0007744|PDB:3D10 source Swiss-Prot : SWS_FT_FI3 42) chain B residue 72 type BINDING sequence E description BINDING => ECO:0000255|PROSITE-ProRule:PRU00448, ECO:0000269|PubMed:20950652, ECO:0007744|PDB:3CZT, ECO:0007744|PDB:3D0Y, ECO:0007744|PDB:3D10 source Swiss-Prot : SWS_FT_FI3 43) chain A residue 15 type BINDING sequence H description BINDING => ECO:0000269|PubMed:20950652, ECO:0007744|PDB:3CZT source Swiss-Prot : SWS_FT_FI1 44) chain A residue 25 type BINDING sequence H description BINDING => ECO:0000269|PubMed:20950652, ECO:0007744|PDB:3CZT source Swiss-Prot : SWS_FT_FI1 45) chain A residue 85 type BINDING sequence H description BINDING => ECO:0000269|PubMed:20950652, ECO:0007744|PDB:3CZT source Swiss-Prot : SWS_FT_FI1 46) chain B residue 15 type BINDING sequence H description BINDING => ECO:0000269|PubMed:20950652, ECO:0007744|PDB:3CZT source Swiss-Prot : SWS_FT_FI1 47) chain B residue 25 type BINDING sequence H description BINDING => ECO:0000269|PubMed:20950652, ECO:0007744|PDB:3CZT source Swiss-Prot : SWS_FT_FI1 48) chain B residue 85 type BINDING sequence H description BINDING => ECO:0000269|PubMed:20950652, ECO:0007744|PDB:3CZT source Swiss-Prot : SWS_FT_FI1 49) chain B residue 90 type BINDING sequence H description BINDING => ECO:0000269|PubMed:20950652, ECO:0007744|PDB:3CZT source Swiss-Prot : SWS_FT_FI1 50) chain A residue 18 type BINDING sequence S description BINDING => ECO:0000269|PubMed:20950652, ECO:0007744|PDB:3CZT, ECO:0007744|PDB:3D0Y, ECO:0007744|PDB:3D10 source Swiss-Prot : SWS_FT_FI2 51) chain B residue 31 type BINDING sequence E description BINDING => ECO:0000269|PubMed:20950652, ECO:0007744|PDB:3CZT, ECO:0007744|PDB:3D0Y, ECO:0007744|PDB:3D10 source Swiss-Prot : SWS_FT_FI2 52) chain A residue 21 type BINDING sequence E description BINDING => ECO:0000269|PubMed:20950652, ECO:0007744|PDB:3CZT, ECO:0007744|PDB:3D0Y, ECO:0007744|PDB:3D10 source Swiss-Prot : SWS_FT_FI2 53) chain A residue 23 type BINDING sequence D description BINDING => ECO:0000269|PubMed:20950652, ECO:0007744|PDB:3CZT, ECO:0007744|PDB:3D0Y, ECO:0007744|PDB:3D10 source Swiss-Prot : SWS_FT_FI2 54) chain A residue 26 type BINDING sequence K description BINDING => ECO:0000269|PubMed:20950652, ECO:0007744|PDB:3CZT, ECO:0007744|PDB:3D0Y, ECO:0007744|PDB:3D10 source Swiss-Prot : SWS_FT_FI2 55) chain A residue 31 type BINDING sequence E description BINDING => ECO:0000269|PubMed:20950652, ECO:0007744|PDB:3CZT, ECO:0007744|PDB:3D0Y, ECO:0007744|PDB:3D10 source Swiss-Prot : SWS_FT_FI2 56) chain B residue 18 type BINDING sequence S description BINDING => ECO:0000269|PubMed:20950652, ECO:0007744|PDB:3CZT, ECO:0007744|PDB:3D0Y, ECO:0007744|PDB:3D10 source Swiss-Prot : SWS_FT_FI2 57) chain B residue 21 type BINDING sequence E description BINDING => ECO:0000269|PubMed:20950652, ECO:0007744|PDB:3CZT, ECO:0007744|PDB:3D0Y, ECO:0007744|PDB:3D10 source Swiss-Prot : SWS_FT_FI2 58) chain B residue 23 type BINDING sequence D description BINDING => ECO:0000269|PubMed:20950652, ECO:0007744|PDB:3CZT, ECO:0007744|PDB:3D0Y, ECO:0007744|PDB:3D10 source Swiss-Prot : SWS_FT_FI2 59) chain B residue 26 type BINDING sequence K description BINDING => ECO:0000269|PubMed:20950652, ECO:0007744|PDB:3CZT, ECO:0007744|PDB:3D0Y, ECO:0007744|PDB:3D10 source Swiss-Prot : SWS_FT_FI2 60) chain A residue 61-73 type prosite sequence DNDGDGECDFQEF description EF_HAND_1 EF-hand calcium-binding domain. DNDGDGECDfqEF source prosite : PS00018 61) chain A residue 56-77 type prosite sequence VMETLDNDGDGECDFQEFMAFV description S100_CABP S-100/ICaBP type calcium binding protein signature. VMetLDndgDgecDFqEFmaFV source prosite : PS00303

Display surface Download Links