eF-site ID 3h7w-AB PDB Code 3h7w Chain A, B click to enlarge Title Crystal structure of the high affinity heterodimer of HIF2 alpha and ARNT C-terminal PAS domains with the artificial ligand THS017 Classification TRANSCRIPTION Compound Endothelial PAS domain-containing protein 1 Source Homo sapiens (Human) (ARNT_HUMAN) Sequence A:  FKGLDSKTFLSEHSMDMKFTYCDDRITELIGYHPEELLGR SAYEFYHALDSENMTKSHQNLCTKGQVVSGQYRMLAKHGG YVWLETQGTVIYPQCIMCVNYVLSEIEK B:  CQPTRFISRHNIEGIFTFVDHRCVATVGYQPQELLGKNIV EFCHPEDQQLLRDSFQQVVKLKGQVLSVMFRFRSKNQEWL WMRTSSFTFQNPYSDEIEYIICTNTNVKNS Description Functional site 1) chain A residue 248 type sequence H description BINDING SITE FOR RESIDUE 018 A 1 source : AC1 2) chain A residue 252 type sequence M description BINDING SITE FOR RESIDUE 018 A 1 source : AC1 3) chain A residue 277 type sequence A description BINDING SITE FOR RESIDUE 018 A 1 source : AC1 4) chain A residue 281 type sequence Y description BINDING SITE FOR RESIDUE 018 A 1 source : AC1 5) chain A residue 289 type sequence M description BINDING SITE FOR RESIDUE 018 A 1 source : AC1 6) chain A residue 292 type sequence S description BINDING SITE FOR RESIDUE 018 A 1 source : AC1 7) chain A residue 293 type sequence H description BINDING SITE FOR RESIDUE 018 A 1 source : AC1 8) chain A residue 302 type sequence V description BINDING SITE FOR RESIDUE 018 A 1 source : AC1 9) chain A residue 304 type sequence S description BINDING SITE FOR RESIDUE 018 A 1 source : AC1 10) chain A residue 307 type sequence Y description BINDING SITE FOR RESIDUE 018 A 1 source : AC1 11) chain A residue 309 type sequence M description BINDING SITE FOR RESIDUE 018 A 1 source : AC1 12) chain A residue 321 type sequence T description BINDING SITE FOR RESIDUE 018 A 1 source : AC1 13) chain A residue 339 type sequence C description BINDING SITE FOR RESIDUE 018 A 1 source : AC1 14) chain A residue 341 type sequence N description BINDING SITE FOR RESIDUE 018 A 1 source : AC1

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