eF-site ID 3h7s-AB PDB Code 3h7s Chain A, B click to enlarge Title Crystal structures of K63-linked di- and tri-ubiquitin reveal a highly extended chain architecture Classification SIGNALING PROTEIN Compound Ubiquitin Source (UBIQ_HUMAN) Sequence A:  MQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQ QRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRG B:  MQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQ QRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRG Description Functional site 1) chain A residue 1 type sequence M description BINDING SITE FOR RESIDUE ZN A 101 source : AC1 2) chain A residue 16 type sequence E description BINDING SITE FOR RESIDUE ZN A 101 source : AC1 3) chain A residue 32 type sequence D description BINDING SITE FOR RESIDUE ZN A 101 source : AC1 4) chain A residue 18 type sequence E description BINDING SITE FOR RESIDUE ZN A 102 source : AC2 5) chain A residue 21 type sequence D description BINDING SITE FOR RESIDUE ZN A 102 source : AC2 6) chain A residue 24 type sequence E description BINDING SITE FOR RESIDUE ZN A 103 source : AC3 7) chain A residue 52 type sequence D description BINDING SITE FOR RESIDUE ZN A 103 source : AC3 8) chain A residue 6 type sequence K description BINDING SITE FOR RESIDUE ZN A 104 source : AC4 9) chain A residue 64 type sequence E description BINDING SITE FOR RESIDUE ZN A 104 source : AC4 10) chain A residue 68 type sequence H description BINDING SITE FOR RESIDUE ZN A 104 source : AC4 11) chain B residue 68 type sequence H description BINDING SITE FOR RESIDUE ZN A 105 source : AC5 12) chain B residue 18 type sequence E description BINDING SITE FOR RESIDUE ZN B 101 source : AC7 13) chain B residue 21 type sequence D description BINDING SITE FOR RESIDUE ZN B 101 source : AC7 14) chain B residue 24 type sequence E description BINDING SITE FOR RESIDUE ZN B 102 source : AC8 15) chain B residue 52 type sequence D description BINDING SITE FOR RESIDUE ZN B 102 source : AC8 16) chain B residue 64 type sequence E description BINDING SITE FOR RESIDUE ZN B 103 source : AC9 17) chain B residue 68 type sequence H description BINDING SITE FOR RESIDUE ZN B 103 source : AC9 18) chain B residue 1 type sequence M description BINDING SITE FOR RESIDUE ZN B 104 source : BC1 19) chain B residue 16 type sequence E description BINDING SITE FOR RESIDUE ZN B 104 source : BC1 20) chain B residue 32 type sequence D description BINDING SITE FOR RESIDUE ZN B 104 source : BC1 21) chain A residue 54 type SITE sequence R description Interacts with activating enzyme source Swiss-Prot : SWS_FT_FI1 22) chain A residue 72 type SITE sequence R description Interacts with activating enzyme source Swiss-Prot : SWS_FT_FI1 23) chain B residue 54 type SITE sequence R description Interacts with activating enzyme source Swiss-Prot : SWS_FT_FI1 24) chain B residue 72 type SITE sequence R description Interacts with activating enzyme source Swiss-Prot : SWS_FT_FI1 25) chain A residue 68 type SITE sequence H description Essential for function source Swiss-Prot : SWS_FT_FI2 26) chain B residue 68 type SITE sequence H description Essential for function source Swiss-Prot : SWS_FT_FI2 27) chain A residue 65 type MOD_RES sequence S description Phosphoserine; by PINK1 => ECO:0000269|PubMed:24660806, ECO:0000269|PubMed:24751536, ECO:0000269|PubMed:24784582, ECO:0000269|PubMed:25527291 source Swiss-Prot : SWS_FT_FI3 28) chain B residue 65 type MOD_RES sequence S description Phosphoserine; by PINK1 => ECO:0000269|PubMed:24660806, ECO:0000269|PubMed:24751536, ECO:0000269|PubMed:24784582, ECO:0000269|PubMed:25527291 source Swiss-Prot : SWS_FT_FI3 29) chain A residue 63 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16543144, ECO:0000269|PubMed:18719106 source Swiss-Prot : SWS_FT_FI12 30) chain B residue 63 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16543144, ECO:0000269|PubMed:18719106 source Swiss-Prot : SWS_FT_FI12 31) chain B residue 66 type MOD_RES sequence T description (Microbial infection) ADP-ribosylthreonine => ECO:0000269|PubMed:32330457 source Swiss-Prot : SWS_FT_FI4 32) chain A residue 66 type MOD_RES sequence T description (Microbial infection) ADP-ribosylthreonine => ECO:0000269|PubMed:32330457 source Swiss-Prot : SWS_FT_FI4 33) chain A residue 6 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16443603 source Swiss-Prot : SWS_FT_FI6 34) chain B residue 6 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16443603 source Swiss-Prot : SWS_FT_FI6 35) chain B residue 11 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16443603, ECO:0000269|PubMed:16543144 source Swiss-Prot : SWS_FT_FI8 36) chain B residue 48 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16443603, ECO:0000269|PubMed:16543144 source Swiss-Prot : SWS_FT_FI8 37) chain A residue 11 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16443603, ECO:0000269|PubMed:16543144 source Swiss-Prot : SWS_FT_FI8 38) chain A residue 48 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16443603, ECO:0000269|PubMed:16543144 source Swiss-Prot : SWS_FT_FI8 39) chain A residue 27-52 type prosite sequence KAKIQDKEGIPPDQQRLIFAGKQLED description UBIQUITIN_1 Ubiquitin domain signature. KakIqDkegIPpdqQrLIFaGkqleD source prosite : PS00299 40) chain A residue 33 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:25752577 source Swiss-Prot : SWS_FT_FI11 41) chain B residue 33 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:25752577 source Swiss-Prot : SWS_FT_FI11 42) chain A residue 29 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16543144, ECO:0000269|PubMed:25752573, ECO:0000269|PubMed:25752577, ECO:0000269|PubMed:34239127 source Swiss-Prot : SWS_FT_FI10 43) chain B residue 29 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16543144, ECO:0000269|PubMed:25752573, ECO:0000269|PubMed:25752577, ECO:0000269|PubMed:34239127 source Swiss-Prot : SWS_FT_FI10 44) chain A residue 27 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000305|PubMed:15466860 source Swiss-Prot : SWS_FT_FI9 45) chain B residue 27 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000305|PubMed:15466860 source Swiss-Prot : SWS_FT_FI9

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