eF-site ID 3h7p-AB PDB Code 3h7p Chain A, B click to enlarge Title Crystal structure of K63-linked di-ubiquitin Classification SIGNALING PROTEIN Compound Ubiquitin Source (UBIQ_HUMAN) Sequence A:  MQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQ QRLIFAGKQLEDGRTLSDYNIQRESTLHLVLRLRG B:  MQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQ QRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGG Description Functional site 1) chain A residue 1 type sequence M description BINDING SITE FOR RESIDUE CD A 77 source : AC1 2) chain A residue 16 type sequence E description BINDING SITE FOR RESIDUE CD A 77 source : AC1 3) chain A residue 32 type sequence D description BINDING SITE FOR RESIDUE CD A 77 source : AC1 4) chain B residue 76 type sequence G description BINDING SITE FOR RESIDUE CD A 77 source : AC1 5) chain A residue 18 type sequence E description BINDING SITE FOR RESIDUE CD A 78 source : AC2 6) chain A residue 18 type sequence E description BINDING SITE FOR RESIDUE CD A 78 source : AC2 7) chain A residue 21 type sequence D description BINDING SITE FOR RESIDUE CD A 78 source : AC2 8) chain A residue 24 type sequence E description BINDING SITE FOR RESIDUE CD A 79 source : AC3 9) chain A residue 52 type sequence D description BINDING SITE FOR RESIDUE CD A 79 source : AC3 10) chain A residue 64 type sequence E description BINDING SITE FOR RESIDUE CD A 80 source : AC4 11) chain A residue 68 type sequence H description BINDING SITE FOR RESIDUE CD A 80 source : AC4 12) chain B residue 1 type sequence M description BINDING SITE FOR RESIDUE CD B 77 source : AC5 13) chain B residue 16 type sequence E description BINDING SITE FOR RESIDUE CD B 77 source : AC5 14) chain B residue 32 type sequence D description BINDING SITE FOR RESIDUE CD B 77 source : AC5 15) chain B residue 18 type sequence E description BINDING SITE FOR RESIDUE CD B 78 source : AC6 16) chain B residue 18 type sequence E description BINDING SITE FOR RESIDUE CD B 78 source : AC6 17) chain B residue 21 type sequence D description BINDING SITE FOR RESIDUE CD B 78 source : AC6 18) chain B residue 24 type sequence E description BINDING SITE FOR RESIDUE CD B 79 source : AC7 19) chain B residue 52 type sequence D description BINDING SITE FOR RESIDUE CD B 79 source : AC7 20) chain B residue 66 type MOD_RES sequence T description (Microbial infection) ADP-ribosylthreonine => ECO:0000269|PubMed:32330457 source Swiss-Prot : SWS_FT_FI4 21) chain B residue 54 type SITE sequence R description Interacts with activating enzyme source Swiss-Prot : SWS_FT_FI1 22) chain B residue 72 type SITE sequence R description Interacts with activating enzyme source Swiss-Prot : SWS_FT_FI1 23) chain B residue 68 type SITE sequence H description Essential for function source Swiss-Prot : SWS_FT_FI2 24) chain B residue 65 type MOD_RES sequence S description Phosphoserine; by PINK1 => ECO:0000269|PubMed:24660806, ECO:0000269|PubMed:24751536, ECO:0000269|PubMed:24784582, ECO:0000269|PubMed:25527291 source Swiss-Prot : SWS_FT_FI3 25) chain B residue 63 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16543144, ECO:0000269|PubMed:18719106 source Swiss-Prot : SWS_FT_FI12 26) chain B residue 6 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16443603 source Swiss-Prot : SWS_FT_FI6 27) chain B residue 76 type MOD_RES sequence G description ADP-ribosylglycine => ECO:0000269|PubMed:28525742 source Swiss-Prot : SWS_FT_FI5 28) chain B residue 76 type CROSSLNK sequence G description Glycyl lysine isopeptide (Gly-Lys) (interchain with K-? in acceptor proteins) source Swiss-Prot : SWS_FT_FI7 29) chain B residue 11 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16443603, ECO:0000269|PubMed:16543144 source Swiss-Prot : SWS_FT_FI8 30) chain B residue 48 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16443603, ECO:0000269|PubMed:16543144 source Swiss-Prot : SWS_FT_FI8 31) chain B residue 29 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16543144, ECO:0000269|PubMed:25752573, ECO:0000269|PubMed:25752577, ECO:0000269|PubMed:34239127 source Swiss-Prot : SWS_FT_FI10 32) chain B residue 33 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:25752577 source Swiss-Prot : SWS_FT_FI11 33) chain B residue 27 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000305|PubMed:15466860 source Swiss-Prot : SWS_FT_FI9 34) chain A residue 27-52 type prosite sequence KAKIQDKEGIPPDQQRLIFAGKQLED description UBIQUITIN_1 Ubiquitin domain signature. KakIqDkegIPpdqQrLIFaGkqleD source prosite : PS00299 35) chain B residue 27-52 type prosite sequence KAKIQDKEGIPPDQQRLIFAGKQLED description UBIQUITIN_1 Ubiquitin domain signature. KakIqDkegIPpdqQrLIFaGkqleD source prosite : PS00299

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