eF-site ID 3h6k-B
PDB Code 3h6k
Chain B

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Title Crystal Structure of Human 11-beta-hydroxysteroid-dehydrogenase Bound to an Ortho-chlro-sulfonyl-piperazine Inhibitor
Classification OXIDOREDUCTASE
Compound Corticosteroid 11-beta-dehydrogenase isozyme 1
Source Homo sapiens (Human) (DHI1_HUMAN)
Sequence B:  PLNEEFRPEMLQGKKVIVTGASKGIGREMAYHLAKMGAHV
VVTARSKETLQKVVSHCLELGAASAHYIAGTMEDMTFAEQ
FVAQAGKLMGGLDMLILNHITNTSLNLFHDDIHHVRKSME
VNFLSYVVLTVAALPMLKQSNGSIVVVSSLAGKVAYPMVA
AYSASKFALDGFFSSIRKEYSVSRVNVSITLCVLGLIDTE
TAMKAVSGIVHMQAAPKEECALEIIKGGALRQEEVYYDSS
LWTTLLIRNPSRKILEFLYST
Description


Functional site

1) chain B
residue 279
type
sequence L
description BINDING SITE FOR RESIDUE 33T A 293
source : AC2

2) chain B
residue 280
type
sequence Y
description BINDING SITE FOR RESIDUE 33T A 293
source : AC2

3) chain B
residue 41
type
sequence G
description BINDING SITE FOR RESIDUE NAP B 1
source : AC3

4) chain B
residue 43
type
sequence S
description BINDING SITE FOR RESIDUE NAP B 1
source : AC3

5) chain B
residue 44
type
sequence K
description BINDING SITE FOR RESIDUE NAP B 1
source : AC3

6) chain B
residue 45
type
sequence G
description BINDING SITE FOR RESIDUE NAP B 1
source : AC3

7) chain B
residue 46
type
sequence I
description BINDING SITE FOR RESIDUE NAP B 1
source : AC3

8) chain B
residue 66
type
sequence R
description BINDING SITE FOR RESIDUE NAP B 1
source : AC3

9) chain B
residue 67
type
sequence S
description BINDING SITE FOR RESIDUE NAP B 1
source : AC3

10) chain B
residue 92
type
sequence T
description BINDING SITE FOR RESIDUE NAP B 1
source : AC3

11) chain B
residue 93
type
sequence M
description BINDING SITE FOR RESIDUE NAP B 1
source : AC3

12) chain B
residue 119
type
sequence N
description BINDING SITE FOR RESIDUE NAP B 1
source : AC3

13) chain B
residue 120
type
sequence H
description BINDING SITE FOR RESIDUE NAP B 1
source : AC3

14) chain B
residue 121
type
sequence I
description BINDING SITE FOR RESIDUE NAP B 1
source : AC3

15) chain B
residue 123
type
sequence N
description BINDING SITE FOR RESIDUE NAP B 1
source : AC3

16) chain B
residue 168
type
sequence V
description BINDING SITE FOR RESIDUE NAP B 1
source : AC3

17) chain B
residue 169
type
sequence S
description BINDING SITE FOR RESIDUE NAP B 1
source : AC3

18) chain B
residue 170
type
sequence S
description BINDING SITE FOR RESIDUE NAP B 1
source : AC3

19) chain B
residue 183
type
sequence Y
description BINDING SITE FOR RESIDUE NAP B 1
source : AC3

20) chain B
residue 187
type
sequence K
description BINDING SITE FOR RESIDUE NAP B 1
source : AC3

21) chain B
residue 215
type
sequence L
description BINDING SITE FOR RESIDUE NAP B 1
source : AC3

22) chain B
residue 216
type
sequence G
description BINDING SITE FOR RESIDUE NAP B 1
source : AC3

23) chain B
residue 217
type
sequence L
description BINDING SITE FOR RESIDUE NAP B 1
source : AC3

24) chain B
residue 218
type
sequence I
description BINDING SITE FOR RESIDUE NAP B 1
source : AC3

25) chain B
residue 220
type
sequence T
description BINDING SITE FOR RESIDUE NAP B 1
source : AC3

26) chain B
residue 222
type
sequence T
description BINDING SITE FOR RESIDUE NAP B 1
source : AC3

27) chain B
residue 223
type
sequence A
description BINDING SITE FOR RESIDUE NAP B 1
source : AC3

28) chain B
residue 125
type
sequence S
description BINDING SITE FOR RESIDUE 33T B 293
source : AC4

29) chain B
residue 126
type
sequence L
description BINDING SITE FOR RESIDUE 33T B 293
source : AC4

30) chain B
residue 170
type
sequence S
description BINDING SITE FOR RESIDUE 33T B 293
source : AC4

31) chain B
residue 171
type
sequence L
description BINDING SITE FOR RESIDUE 33T B 293
source : AC4

32) chain B
residue 172
type
sequence A
description BINDING SITE FOR RESIDUE 33T B 293
source : AC4

33) chain B
residue 177
type
sequence Y
description BINDING SITE FOR RESIDUE 33T B 293
source : AC4

34) chain B
residue 183
type
sequence Y
description BINDING SITE FOR RESIDUE 33T B 293
source : AC4

35) chain B
residue 215
type
sequence L
description BINDING SITE FOR RESIDUE 33T B 293
source : AC4

36) chain B
residue 216
type
sequence G
description BINDING SITE FOR RESIDUE 33T B 293
source : AC4

37) chain B
residue 217
type
sequence L
description BINDING SITE FOR RESIDUE 33T B 293
source : AC4

38) chain B
residue 222
type
sequence T
description BINDING SITE FOR RESIDUE 33T B 293
source : AC4

39) chain B
residue 226
type
sequence A
description BINDING SITE FOR RESIDUE 33T B 293
source : AC4

40) chain B
residue 207
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine => ECO:0000255
source Swiss-Prot : SWS_FT_FI6

41) chain B
residue 123
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218
source Swiss-Prot : SWS_FT_FI5

42) chain B
residue 162
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218
source Swiss-Prot : SWS_FT_FI5

43) chain B
residue 183
type ACT_SITE
sequence Y
description Proton acceptor
source Swiss-Prot : SWS_FT_FI2

44) chain B
residue 218
type BINDING
sequence I
description BINDING => ECO:0000269|PubMed:15513927, ECO:0000269|PubMed:17919905, ECO:0000269|PubMed:18069989, ECO:0000269|PubMed:18485702, ECO:0000269|PubMed:18553955, ECO:0000269|PubMed:19217779
source Swiss-Prot : SWS_FT_FI3

45) chain B
residue 41
type BINDING
sequence G
description BINDING => ECO:0000269|PubMed:15513927, ECO:0000269|PubMed:17919905, ECO:0000269|PubMed:18069989, ECO:0000269|PubMed:18485702, ECO:0000269|PubMed:18553955, ECO:0000269|PubMed:19217779
source Swiss-Prot : SWS_FT_FI3

46) chain B
residue 92
type BINDING
sequence T
description BINDING => ECO:0000269|PubMed:15513927, ECO:0000269|PubMed:17919905, ECO:0000269|PubMed:18069989, ECO:0000269|PubMed:18485702, ECO:0000269|PubMed:18553955, ECO:0000269|PubMed:19217779
source Swiss-Prot : SWS_FT_FI3

47) chain B
residue 119
type BINDING
sequence N
description BINDING => ECO:0000269|PubMed:15513927, ECO:0000269|PubMed:17919905, ECO:0000269|PubMed:18069989, ECO:0000269|PubMed:18485702, ECO:0000269|PubMed:18553955, ECO:0000269|PubMed:19217779
source Swiss-Prot : SWS_FT_FI3

48) chain B
residue 183
type BINDING
sequence Y
description BINDING => ECO:0000269|PubMed:15513927, ECO:0000269|PubMed:17919905, ECO:0000269|PubMed:18069989, ECO:0000269|PubMed:18485702, ECO:0000269|PubMed:18553955, ECO:0000269|PubMed:19217779
source Swiss-Prot : SWS_FT_FI3

49) chain B
residue 170
type BINDING
sequence S
description BINDING => ECO:0000269|PubMed:15513927, ECO:0007744|PDB:1XU7, ECO:0007744|PDB:1XU9
source Swiss-Prot : SWS_FT_FI4


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