|
|
eF-site ID
|
3h3b-ABCD |
|
PDB Code
|
3h3b |
|
Chain
|
A, B, C, D |
|
click to enlarge
|
|
|
Title
|
Crystal structure of the single-chain Fv (scFv) fragment of an anti-ErbB2 antibody chA21 in complex with residues 1-192 of ErbB2 extracellular domain |
|
Classification
|
IMMUNE SYSTEM |
|
Compound
|
Receptor tyrosine-protein kinase erbB-2 |
|
Source
|
Homo sapiens (Human) (3H3B) |
|
|
Sequence
|
A: |
STQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNLE
LTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRI
VRGTQLFEDNYALAVLDNGDPLNNTTPVTGASPGGLRELQ
LRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLAL
TLIDTNRSRACHPCSPMCKGSRCWGESSEDCQS
|
| B: |
STQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNLE
LTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRI
VRGTQLFEDNYALAVLDNGDPLNNTTPVTGASPGGLRELQ
LRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLAL
TLIDTNRSRACHPCSPMCRCWGESSEDCQ
|
| C: |
QPADIVLTQTPSSLPVSVGEKVTMTCKSSQTLLYSNNQKN
YLAWYQQKPGQSPKLLISWAFTRKSGVPDRFTGSGSGTDF
TLTIGSVKAEDLAVYYCQQYSNYPWTFGGGTRLEIEVQLQ
QSGPEVVKTGASVKISCKASGYSFTGYFINWVKKNSGKSP
EWIGHISSSYATSTYNQKFKNKAAFTVDTSSSTAFMQLNS
LTSEDSAVYYCVRSGNYEEYAMDYWGQGTSVTVS
|
| D: |
QPADIVLTQTPSSLPVSVGEKVTMTCKSSQTLLYSNNQKN
YLAWYQQKPGQSPKLLISWAFTRKSGVPDRFTGSGSGTDF
TLTIGSVKAEDLAVYYCQQYSNYPWTFGGGTRLEIKSEVQ
LQQSGPEVVKTGASVKISCKASGYSFTGYFINWVKKNSGK
SPEWIGHISSSYATSTYNQKFKNKAAFTVDTSSSTAFMQL
NSLTSEDSAVYYCVRSGNYEEYAMDYWGQGTSVTVS
|
|
|
Description
|
|
Functional site
|
|
|
1)
|
chain |
A |
| residue |
160 |
| type |
MOD_RES |
| sequence |
T
|
| description |
Phosphothreonine => ECO:0007744|PubMed:23186163
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
2)
|
chain |
B |
| residue |
160 |
| type |
MOD_RES |
| sequence |
T
|
| description |
Phosphothreonine => ECO:0007744|PubMed:23186163
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
3)
|
chain |
A |
| residue |
46 |
| type |
CARBOHYD |
| sequence |
N
|
| description |
N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:20696930, ECO:0007744|PDB:2A91, ECO:0007744|PDB:3MZW
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
4)
|
chain |
B |
| residue |
46 |
| type |
CARBOHYD |
| sequence |
N
|
| description |
N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:20696930, ECO:0007744|PDB:2A91, ECO:0007744|PDB:3MZW
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
5)
|
chain |
A |
| residue |
102 |
| type |
CARBOHYD |
| sequence |
N
|
| description |
N-linked (GlcNAc...) asparagine => ECO:0000255
|
| source |
Swiss-Prot : SWS_FT_FI3
|
|
|
6)
|
chain |
B |
| residue |
102 |
| type |
CARBOHYD |
| sequence |
N
|
| description |
N-linked (GlcNAc...) asparagine => ECO:0000255
|
| source |
Swiss-Prot : SWS_FT_FI3
|
|
|
7)
|
chain |
A |
| residue |
165 |
| type |
CARBOHYD |
| sequence |
N
|
| description |
N-linked (GlcNAc...) asparagine => ECO:0000255, ECO:0007744|PDB:1N8Z, ECO:0007744|PDB:1S78, ECO:0007744|PDB:2A91, ECO:0007744|PDB:3N85
|
| source |
Swiss-Prot : SWS_FT_FI4
|
|
|
8)
|
chain |
B |
| residue |
165 |
| type |
CARBOHYD |
| sequence |
N
|
| description |
N-linked (GlcNAc...) asparagine => ECO:0000255, ECO:0007744|PDB:1N8Z, ECO:0007744|PDB:1S78, ECO:0007744|PDB:2A91, ECO:0007744|PDB:3N85
|
| source |
Swiss-Prot : SWS_FT_FI4
|
|
|
|