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eF-site ID
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3h3b-A |
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PDB Code
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3h3b |
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Chain
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A |
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click to enlarge
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Title
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Crystal structure of the single-chain Fv (scFv) fragment of an anti-ErbB2 antibody chA21 in complex with residues 1-192 of ErbB2 extracellular domain |
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Classification
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IMMUNE SYSTEM |
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Compound
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Receptor tyrosine-protein kinase erbB-2 |
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Source
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Homo sapiens (Human) (3H3B) |
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Sequence
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A: |
STQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNLE
LTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRI
VRGTQLFEDNYALAVLDNGDPLNNTTPVTGASPGGLRELQ
LRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLAL
TLIDTNRSRACHPCSPMCKGSRCWGESSEDCQS
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Description
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Functional site
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|
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1)
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chain |
A |
| residue |
160 |
| type |
MOD_RES |
| sequence |
T
|
| description |
Phosphothreonine => ECO:0007744|PubMed:23186163
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| source |
Swiss-Prot : SWS_FT_FI1
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2)
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chain |
A |
| residue |
46 |
| type |
CARBOHYD |
| sequence |
N
|
| description |
N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:20696930, ECO:0007744|PDB:2A91, ECO:0007744|PDB:3MZW
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| source |
Swiss-Prot : SWS_FT_FI2
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3)
|
chain |
A |
| residue |
102 |
| type |
CARBOHYD |
| sequence |
N
|
| description |
N-linked (GlcNAc...) asparagine => ECO:0000255
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| source |
Swiss-Prot : SWS_FT_FI3
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4)
|
chain |
A |
| residue |
165 |
| type |
CARBOHYD |
| sequence |
N
|
| description |
N-linked (GlcNAc...) asparagine => ECO:0000255, ECO:0007744|PDB:1N8Z, ECO:0007744|PDB:1S78, ECO:0007744|PDB:2A91, ECO:0007744|PDB:3N85
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| source |
Swiss-Prot : SWS_FT_FI4
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