eF-site ID 3h0l-P
PDB Code 3h0l
Chain P

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Title Structure of trna-dependent amidotransferase gatcab from aquifex aeolicus
Classification LIGASE
Compound Glutamyl-tRNA(Gln) amidotransferase subunit A
Source Aquifex aeolicus (GATC_AQUAE)
Sequence P:  MLWKKSLSELRELLKRGEVSPKEVVESFYDRYNQTEEKVK
AYITPLYGKALKQAESLKERELPLFGIPIAVKDNILVEGE
KTTCASKILENFVAPYDATVIERLKKAGALIVGKTNLDEF
AMGSSTEYSAFFPTKNPWDLERVPGGSSGGSAASVAVLSA
PVSLGSDTGGSIRQPASFCGVIGIKPTYGRVSRYGLVAFA
SSLDQIGVFGRRTEDVALVLEVISGWDEKDSTSAKVPVPE
WSEEVKKEVKGLKIGLPKEFFEYELQPQVKEAFENFIKEL
EKEGFEIKEVSLPHVKYSIPTYYIIAPSEASSNLARYDGV
RYGYRAKEYKDIFEMYARTRDEGFGPEVKRRIMLGTFALS
AGYYDAYYLKAQKVRRLITNDFLKAFEEVDVIASPTTPTL
PFKFGERLENPIEMYLSDILTVPANLAGLPAISIPIAWKD
GLPVGGQLIGKHWDETTLLQISYLWEQKFKHYEKIPLT
Description (1)  Glutamyl-tRNA(Gln) amidotransferase subunit A (E.C.6.3.5.-), Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B (E.C.6.3.5.-), Glutamyl-tRNA(Gln) amidotransferase subunit C (E.C.6.3.5.-)


Functional site

1) chain P
residue 121
type
ligand
sequence A
description BINDING SITE FOR RESIDUE ASN P 906
source : DC3

2) chain P
residue 122
type
ligand
sequence M
description BINDING SITE FOR RESIDUE ASN P 906
source : DC3

3) chain P
residue 123
type
ligand
sequence G
description BINDING SITE FOR RESIDUE ASN P 906
source : DC3

4) chain P
residue 124
type
ligand
sequence S
description BINDING SITE FOR RESIDUE ASN P 906
source : DC3

5) chain P
residue 147
type
ligand
sequence S
description BINDING SITE FOR RESIDUE ASN P 906
source : DC3

6) chain P
residue 168
type
ligand
sequence T
description BINDING SITE FOR RESIDUE ASN P 906
source : DC3

7) chain P
residue 169
type
ligand
sequence G
description BINDING SITE FOR RESIDUE ASN P 906
source : DC3

8) chain P
residue 170
type
ligand
sequence G
description BINDING SITE FOR RESIDUE ASN P 906
source : DC3

9) chain P
residue 171
type
ligand
sequence S
description BINDING SITE FOR RESIDUE ASN P 906
source : DC3

10) chain P
residue 199
type
ligand
sequence F
description BINDING SITE FOR RESIDUE ASN P 906
source : DC3

11) chain P
residue 302
type
ligand
sequence Y
description BINDING SITE FOR RESIDUE ASN P 906
source : DC3

12) chain P
residue 351
type
ligand
sequence R
description BINDING SITE FOR RESIDUE ASN P 906
source : DC3

13) chain P
residue 418
type
ligand
sequence D
description BINDING SITE FOR RESIDUE ASN P 906
source : DC3

14) chain P
residue 72
type ACT_SITE
ligand
sequence K
description Charge relay system (By similarity).
source Swiss-Prot : SWS_FT_FI11

15) chain P
residue 147
type ACT_SITE
ligand
sequence S
description Charge relay system (By similarity).
source Swiss-Prot : SWS_FT_FI11

16) chain P
residue 171
type ACT_SITE
ligand
sequence S
description Acyl-ester intermediate (By similarity).
source Swiss-Prot : SWS_FT_FI12

17) chain P
residue 145-176
type prosite
ligand
sequence GGSSGGSAASVAVLSAPVSLGSDTGGSIRQPA
description Amidases signature.G-[GAV]-S-[GS](2)-G-x-[GSAE]-[GSAVYCT]-x-[LIVMT]-[GSA]-x(6)-[GSAT]-x-[GA]-x-[DE]-x-[GA]-x-S-[LIVM]-R-x-P-[GSACTL].
source prosite : PS00571


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