eF-site ID 3gjf-ABCDEFHKLM
PDB Code 3gjf
Chain A, B, C, D, E, F, H, K, L, M

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Title Rational development of high-affinity T-cell receptor-like antibodies
Classification IMMUNE SYSTEM
Compound HLA class I histocompatibility antigen, A-2 alpha chain
Source Homo sapiens (Human) (3GJF)
Sequence A:  GSHSMRYFFTSVSRPGRGEPRFIAVGYVDDTQFVRFDSDA
ASQRMEPRAPWIEQEGPEYWDGETRKVKAHSQTHRVDLGT
LRGYYNQSEAGSHTVQRMYGCDVGSDWRFLRGYHQYAYDG
KDYIALKEDLRSWTAADMAAQTTKHKWEAAHVAEQLRAYL
EGTCVEWLRRYLENGKETLQRTDAPKTHMTHHAVSDHEAT
LRCWALSFYPAEITLTWQRDGEDQTQDTELVETRPAGDGT
FQKWAAVVVPSGQEQRYTCHVQHEGLPKPLTLRWEP
B:  MIQRTPKIQVYSRHPAENGKSNFLNCYVSGFHPSDIEVDL
LKNGERIEKVEHSDLSFSKDWSFYLLYYTEFTPTEKDEYA
CRVNHVTLSQPKIVKWDRDM
C:  SLLMWITQV
D:  GSHSMRYFFTSVSRPGRGEPRFIAVGYVDDTQFVRFDSDA
ASQRMEPRAPWIEQEGPEYWDGETRKVKAHSQTHRVDLGT
LRGYYNQSEAGSHTVQRMYGCDVGSDWRFLRGYHQYAYDG
KDYIALKEDLRSWTAADMAAQTTKHKWEAAHVAEQLRAYL
EGTCVEWLRRYLENGKETLQRTDAPKTHMTHHAVSDHEAT
LRCWALSFYPAEITLTWQRDGEDQTQDTELVETRPAGDGT
FQKWAAVVVPSGQEQRYTCHVQHEGLPKPLTLRWEP
E:  MIQRTPKIQVYSRHPAENGKSNFLNCYVSGFHPSDIEVDL
LKNGERIEKVEHSDLSFSKDWSFYLLYYTEFTPTEKDEYA
CRVNHVTLSQPKIVKWDRDM
F:  SLLMWITQV
H:  EVQLLESGGGLVQPGGSLRLSCAASGFTFSTYQMSWVRQA
PGKGLEWVSGIVSSGGSTAYADSVKGRFTISRDNSKNTLY
LQMNSLRAEDTAVYYCAGELLPYYGMDVWGQGTTVTVSSA
STKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSW
NSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTY
ICNVNHKPSNTKVDKKVEPK
K:  QSELTQPRSVSGSPGQSVTISCTGTSRDVGGYNYVSWYQQ
HPGKAPKLIIHDVIERSSGVPDRFSGSKSGNTASLTISGL
QAEDEADYYCWSFAGSYYVFGTGTDVTVLGQPKANPTVTL
FPPSSEELQANKATLVCLISDFYPGAVTVAWKADGSPVKA
GVETTKPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTH
EGNTVEKTVAPT
L:  QSELTQPRSVSGSPGQSVTISCTGTSRDVGGYNYVSWYQQ
HPGKAPKLIIHDVIERSSGVPDRFSGSKSGNTASLTISGL
QAEDEADYYCWSFAGSYYVFGTGTDVTVLGQPKANPTVTL
FPPSSEELQANKATLVCLISDFYPGAVTVAWKAAGVETTK
PSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGNTVE
KTVAPT
M:  EVQLLESGGGLVQPGGSLRLSCAASGFTFSTYQMSWVRQA
PGKGLEWVSGIVSSGGSTAYADSVKGRFTISRDNSKNTLY
LQMNSLRAEDTAVYYCAGELLPYYGMDVWGQGTTVTVSSA
STKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSW
NSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTY
ICNVNHKPSNTKVDKKVEPK
Description


Functional site
1) chain A
residue 86
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218
source Swiss-Prot : SWS_FT_FI4
2) chain D
residue 86
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218
source Swiss-Prot : SWS_FT_FI4
3) chain B
residue 2
type MOD_RES
sequence Q
description Pyrrolidone carboxylic acid; in form pI 5.3 => ECO:0000269|PubMed:7554280
source Swiss-Prot : SWS_FT_FI1
4) chain D
residue 143
type MOD_RES
sequence T
description Pyrrolidone carboxylic acid; in form pI 5.3 => ECO:0000269|PubMed:7554280
source Swiss-Prot : SWS_FT_FI1
5) chain D
residue 146
type MOD_RES
sequence K
description Pyrrolidone carboxylic acid; in form pI 5.3 => ECO:0000269|PubMed:7554280
source Swiss-Prot : SWS_FT_FI1
6) chain D
residue 171
type MOD_RES
sequence Y
description Pyrrolidone carboxylic acid; in form pI 5.3 => ECO:0000269|PubMed:7554280
source Swiss-Prot : SWS_FT_FI1
7) chain E
residue 2
type MOD_RES
sequence Q
description Pyrrolidone carboxylic acid; in form pI 5.3 => ECO:0000269|PubMed:7554280
source Swiss-Prot : SWS_FT_FI1
8) chain A
residue 84
type MOD_RES
sequence Y
description Pyrrolidone carboxylic acid; in form pI 5.3 => ECO:0000269|PubMed:7554280
source Swiss-Prot : SWS_FT_FI1
9) chain A
residue 143
type MOD_RES
sequence T
description Pyrrolidone carboxylic acid; in form pI 5.3 => ECO:0000269|PubMed:7554280
source Swiss-Prot : SWS_FT_FI1
10) chain A
residue 146
type MOD_RES
sequence K
description Pyrrolidone carboxylic acid; in form pI 5.3 => ECO:0000269|PubMed:7554280
source Swiss-Prot : SWS_FT_FI1
11) chain A
residue 171
type MOD_RES
sequence Y
description Pyrrolidone carboxylic acid; in form pI 5.3 => ECO:0000269|PubMed:7554280
source Swiss-Prot : SWS_FT_FI1
12) chain D
residue 7
type MOD_RES
sequence Y
description Pyrrolidone carboxylic acid; in form pI 5.3 => ECO:0000269|PubMed:7554280
source Swiss-Prot : SWS_FT_FI1
13) chain D
residue 73
type MOD_RES
sequence T
description Pyrrolidone carboxylic acid; in form pI 5.3 => ECO:0000269|PubMed:7554280
source Swiss-Prot : SWS_FT_FI1
14) chain D
residue 84
type MOD_RES
sequence Y
description Pyrrolidone carboxylic acid; in form pI 5.3 => ECO:0000269|PubMed:7554280
source Swiss-Prot : SWS_FT_FI1
15) chain B
residue 1
type CARBOHYD
sequence I
description N-linked (Glc) (glycation) isoleucine; in hemodialysis-associated amyloidosis => ECO:0000269|PubMed:7918443
source Swiss-Prot : SWS_FT_FI2
16) chain E
residue 1
type CARBOHYD
sequence I
description N-linked (Glc) (glycation) isoleucine; in hemodialysis-associated amyloidosis => ECO:0000269|PubMed:7918443
source Swiss-Prot : SWS_FT_FI2
17) chain D
residue 116
type CARBOHYD
sequence Y
description N-linked (Glc) (glycation) isoleucine; in hemodialysis-associated amyloidosis => ECO:0000269|PubMed:7918443
source Swiss-Prot : SWS_FT_FI2
18) chain D
residue 159
type CARBOHYD
sequence Y
description N-linked (Glc) (glycation) isoleucine; in hemodialysis-associated amyloidosis => ECO:0000269|PubMed:7918443
source Swiss-Prot : SWS_FT_FI2
19) chain B
residue 19
type CARBOHYD
sequence K
description N-linked (Glc) (glycation) lysine; in vitro => ECO:0000269|PubMed:7918443
source Swiss-Prot : SWS_FT_FI3
20) chain E
residue 58
type CARBOHYD
sequence K
description N-linked (Glc) (glycation) lysine; in vitro => ECO:0000269|PubMed:7918443
source Swiss-Prot : SWS_FT_FI3
21) chain E
residue 91
type CARBOHYD
sequence K
description N-linked (Glc) (glycation) lysine; in vitro => ECO:0000269|PubMed:7918443
source Swiss-Prot : SWS_FT_FI3
22) chain E
residue 94
type CARBOHYD
sequence K
description N-linked (Glc) (glycation) lysine; in vitro => ECO:0000269|PubMed:7918443
source Swiss-Prot : SWS_FT_FI3
23) chain B
residue 41
type CARBOHYD
sequence K
description N-linked (Glc) (glycation) lysine; in vitro => ECO:0000269|PubMed:7918443
source Swiss-Prot : SWS_FT_FI3
24) chain B
residue 48
type CARBOHYD
sequence K
description N-linked (Glc) (glycation) lysine; in vitro => ECO:0000269|PubMed:7918443
source Swiss-Prot : SWS_FT_FI3
25) chain B
residue 58
type CARBOHYD
sequence K
description N-linked (Glc) (glycation) lysine; in vitro => ECO:0000269|PubMed:7918443
source Swiss-Prot : SWS_FT_FI3
26) chain B
residue 91
type CARBOHYD
sequence K
description N-linked (Glc) (glycation) lysine; in vitro => ECO:0000269|PubMed:7918443
source Swiss-Prot : SWS_FT_FI3
27) chain B
residue 94
type CARBOHYD
sequence K
description N-linked (Glc) (glycation) lysine; in vitro => ECO:0000269|PubMed:7918443
source Swiss-Prot : SWS_FT_FI3
28) chain E
residue 19
type CARBOHYD
sequence K
description N-linked (Glc) (glycation) lysine; in vitro => ECO:0000269|PubMed:7918443
source Swiss-Prot : SWS_FT_FI3
29) chain E
residue 41
type CARBOHYD
sequence K
description N-linked (Glc) (glycation) lysine; in vitro => ECO:0000269|PubMed:7918443
source Swiss-Prot : SWS_FT_FI3
30) chain E
residue 48
type CARBOHYD
sequence K
description N-linked (Glc) (glycation) lysine; in vitro => ECO:0000269|PubMed:7918443
source Swiss-Prot : SWS_FT_FI3
31) chain L
residue 194-200
type prosite
sequence YSCQVTH
description IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YSCQVTH
source prosite : PS00290
32) chain H
residue 200-206
type prosite
sequence YICNVNH
description IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YSCQVTH
source prosite : PS00290
33) chain B
residue 78-84
type prosite
sequence YACRVNH
description IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YSCQVTH
source prosite : PS00290
34) chain A
residue 257-263
type prosite
sequence YTCHVQH
description IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YSCQVTH
source prosite : PS00290

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