eF-site ID 3giz-HL PDB Code 3giz Chain H, L click to enlarge Title Crystal structure of the Fab fragment of anti-CD20 antibody Ofatumumab Classification IMMUNE SYSTEM Compound Fab fragment of anti-CD20 antibody Ofatumumab, light chain Source (3GIZ) Sequence H:  EVQLVESGGGLVQPGRSLRLSCAASGFTFNDYAMHWVRQA PGKGLEWVSTISWNSGSIGYADSVKGRFTISRDNAKKSLY LQMNSLRAEDTALYYCAKDIQYGNYYYGMDVWGQGTTVTV SSASTKGPSVFPLAPGGTAALGCLVKDYFPEPVTVSWNSG ALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICN VNHKPSNTKVDKKVEP L:  EIVLTQSPATLSLSPGERATLSCRASQSVSSYLAWYQQKP GQAPRLLIYDASNRATGIPARFSGSGSGTDFTLTISSLEP EDFAVYYCQQRSNWPITFGQGTRLEIKRTVAAPSVFIFPP SDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQ ESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQG LSSPVTKSFNR Description Functional site 1) chain L residue 79 type sequence E description BINDING SITE FOR RESIDUE ZN L 212 source : AC1 2) chain L residue 79 type sequence E description BINDING SITE FOR RESIDUE ZN L 212 source : AC1 3) chain L residue 81 type sequence E description BINDING SITE FOR RESIDUE ZN L 212 source : AC1 4) chain L residue 81 type sequence E description BINDING SITE FOR RESIDUE ZN L 212 source : AC1 5) chain H residue 1 type sequence E description BINDING SITE FOR RESIDUE ZN L 213 source : AC2 6) chain H residue 173 type sequence H description BINDING SITE FOR RESIDUE ZN L 213 source : AC2 7) chain L residue 137 type sequence N description BINDING SITE FOR RESIDUE ZN L 213 source : AC2 8) chain L residue 138 type sequence N description BINDING SITE FOR RESIDUE ZN L 213 source : AC2 9) chain L residue 1 type sequence E description BINDING SITE FOR RESIDUE ZN L 214 source : AC3 10) chain L residue 185 type sequence D description BINDING SITE FOR RESIDUE ZN L 214 source : AC3 11) chain L residue 189 type sequence H description BINDING SITE FOR RESIDUE ZN L 214 source : AC3 12) chain H residue 203-209 type prosite sequence YICNVNH description IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YICNVNH source prosite : PS00290 13) chain L residue 192-198 type prosite sequence YACEVTH description IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YICNVNH source prosite : PS00290

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