eF-site ID 3ggj-B PDB Code 3ggj Chain B click to enlarge Title Human hypoxanthine-guanine phosphoribosyltransferase in complex with 9-(2-phosphonoethoxyethyl)guanine Classification TRANSFERASE Compound Hypoxanthine-guanine phosphoribosyltransferase Source Homo sapiens (Human) (HPRT_HUMAN) Sequence B:  RSPGVVISDDEPGYDLDLFCIPNHYAEDLERVFIPHGLIM DRTERLARDVMKEMGGHIVALCVLKGGYKFFADLLDYIKA LNRNSDRSIPMTVDFIRLKSYCNQSGDIKVIGDDLSTLTG KNVLIVEDIIDTGKTMQTLLSLVRQYNPKMVKVASLLVKR TPRSVGYKPDFVGFEIPDKFVVGYALDYNEYFRDLNHVCV ISETGKAKYKA Description Functional site 1) chain B residue 135 type sequence I description BINDING SITE FOR RESIDUE 25H B 218 source : AC2 2) chain B residue 137 type sequence D description BINDING SITE FOR RESIDUE 25H B 218 source : AC2 3) chain B residue 138 type sequence T description BINDING SITE FOR RESIDUE 25H B 218 source : AC2 4) chain B residue 139 type sequence G description BINDING SITE FOR RESIDUE 25H B 218 source : AC2 5) chain B residue 141 type sequence T description BINDING SITE FOR RESIDUE 25H B 218 source : AC2 6) chain B residue 165 type sequence K description BINDING SITE FOR RESIDUE 25H B 218 source : AC2 7) chain B residue 185 type sequence K description BINDING SITE FOR RESIDUE 25H B 218 source : AC2 8) chain B residue 186 type sequence F description BINDING SITE FOR RESIDUE 25H B 218 source : AC2 9) chain B residue 187 type sequence V description BINDING SITE FOR RESIDUE 25H B 218 source : AC2 10) chain B residue 192 type sequence L description BINDING SITE FOR RESIDUE 25H B 218 source : AC2 11) chain B residue 193 type sequence D description BINDING SITE FOR RESIDUE 25H B 218 source : AC2 12) chain B residue 133 type catalytic sequence E description 48 source MCSA : MCSA2 13) chain B residue 134 type catalytic sequence D description 48 source MCSA : MCSA2 14) chain B residue 137 type catalytic sequence D description 48 source MCSA : MCSA2 15) chain B residue 186 type catalytic sequence F description 48 source MCSA : MCSA2 16) chain B residue 199 type catalytic sequence R description 48 source MCSA : MCSA2 17) chain B residue 137 type ACT_SITE sequence D description Proton acceptor => ECO:0000305 source Swiss-Prot : SWS_FT_FI1 18) chain B residue 68 type BINDING sequence K description BINDING => ECO:0000269|PubMed:8044844 source Swiss-Prot : SWS_FT_FI2 19) chain B residue 133 type BINDING sequence E description BINDING => ECO:0000269|PubMed:8044844 source Swiss-Prot : SWS_FT_FI2 20) chain B residue 165 type BINDING sequence K description BINDING => ECO:0000269|PubMed:8044844 source Swiss-Prot : SWS_FT_FI2 21) chain B residue 185 type BINDING sequence K description BINDING => ECO:0000269|PubMed:8044844 source Swiss-Prot : SWS_FT_FI2 22) chain B residue 193 type BINDING sequence D description source Swiss-Prot : SWS_FT_FI3 23) chain B residue 102 type MOD_RES sequence K description N6-acetyllysine => ECO:0000250|UniProtKB:P00493 source Swiss-Prot : SWS_FT_FI5 24) chain B residue 141 type MOD_RES sequence T description Phosphothreonine => ECO:0000250|UniProtKB:P27605 source Swiss-Prot : SWS_FT_FI6 25) chain B residue 114 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate => ECO:0007744|PubMed:28112733 source Swiss-Prot : SWS_FT_FI7

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