eF-site ID 3ggj-A
PDB Code 3ggj
Chain A

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Title Human hypoxanthine-guanine phosphoribosyltransferase in complex with 9-(2-phosphonoethoxyethyl)guanine
Classification TRANSFERASE
Compound Hypoxanthine-guanine phosphoribosyltransferase
Source Homo sapiens (Human) (HPRT_HUMAN)
Sequence A:  SPGVVISDDEPGYDLDLFCIPNHYAEDLERVFIPHGLIMD
RTERLARDVMKEMGGHHIVALCVLKGGYKFFADLLDYIKA
LNRNSDRSIPMTVDFIRLKSYCNDQSTGDIKVIGGDDLST
LTGKNVLIVEDIIDTGKTMQTLLSLVRQYNPKMVKVASLL
VKRTPRSVGYKPDFVGFEIPDKFVVGYALDYNEYFRDLNH
VCVISETGKAKYKA
Description


Functional site

1) chain A
residue 107
type
sequence D
description BINDING SITE FOR RESIDUE 25H A 218
source : AC1

2) chain A
residue 110
type
sequence T
description BINDING SITE FOR RESIDUE 25H A 218
source : AC1

3) chain A
residue 137
type
sequence D
description BINDING SITE FOR RESIDUE 25H A 218
source : AC1

4) chain A
residue 138
type
sequence T
description BINDING SITE FOR RESIDUE 25H A 218
source : AC1

5) chain A
residue 139
type
sequence G
description BINDING SITE FOR RESIDUE 25H A 218
source : AC1

6) chain A
residue 140
type
sequence K
description BINDING SITE FOR RESIDUE 25H A 218
source : AC1

7) chain A
residue 141
type
sequence T
description BINDING SITE FOR RESIDUE 25H A 218
source : AC1

8) chain A
residue 165
type
sequence K
description BINDING SITE FOR RESIDUE 25H A 218
source : AC1

9) chain A
residue 185
type
sequence K
description BINDING SITE FOR RESIDUE 25H A 218
source : AC1

10) chain A
residue 186
type
sequence F
description BINDING SITE FOR RESIDUE 25H A 218
source : AC1

11) chain A
residue 187
type
sequence V
description BINDING SITE FOR RESIDUE 25H A 218
source : AC1

12) chain A
residue 192
type
sequence L
description BINDING SITE FOR RESIDUE 25H A 218
source : AC1

13) chain A
residue 133
type catalytic
sequence E
description 48
source MCSA : MCSA1

14) chain A
residue 134
type catalytic
sequence D
description 48
source MCSA : MCSA1

15) chain A
residue 137
type catalytic
sequence D
description 48
source MCSA : MCSA1

16) chain A
residue 186
type catalytic
sequence F
description 48
source MCSA : MCSA1

17) chain A
residue 199
type catalytic
sequence R
description 48
source MCSA : MCSA1

18) chain A
residue 129-141
type prosite
sequence VLIVEDIIDTGKT
description PUR_PYR_PR_TRANSFER Purine/pyrimidine phosphoribosyl transferases signature. VLIVEDIIDTGkT
source prosite : PS00103

19) chain A
residue 137
type ACT_SITE
sequence D
description Proton acceptor => ECO:0000305
source Swiss-Prot : SWS_FT_FI1

20) chain A
residue 68
type BINDING
sequence K
description BINDING => ECO:0000269|PubMed:8044844
source Swiss-Prot : SWS_FT_FI2

21) chain A
residue 133
type BINDING
sequence E
description BINDING => ECO:0000269|PubMed:8044844
source Swiss-Prot : SWS_FT_FI2

22) chain A
residue 165
type BINDING
sequence K
description BINDING => ECO:0000269|PubMed:8044844
source Swiss-Prot : SWS_FT_FI2

23) chain A
residue 185
type BINDING
sequence K
description BINDING => ECO:0000269|PubMed:8044844
source Swiss-Prot : SWS_FT_FI2

24) chain A
residue 193
type BINDING
sequence D
description
source Swiss-Prot : SWS_FT_FI3

25) chain A
residue 102
type MOD_RES
sequence K
description N6-acetyllysine => ECO:0000250|UniProtKB:P00493
source Swiss-Prot : SWS_FT_FI5

26) chain A
residue 141
type MOD_RES
sequence T
description Phosphothreonine => ECO:0000250|UniProtKB:P27605
source Swiss-Prot : SWS_FT_FI6

27) chain A
residue 114
type CROSSLNK
sequence K
description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate => ECO:0007744|PubMed:28112733
source Swiss-Prot : SWS_FT_FI7


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