eF-site ID 3geq-AB PDB Code 3geq Chain A, B click to enlarge Title Structural basis for the chemical rescue of Src kinase activity Classification TRANSFERASE Compound Proto-oncogene tyrosine-protein kinase Src Source Gallus gallus (Chicken) (SRC_CHICK) Sequence A:  GHMQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWN GTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYA VVSEEPIYIVTEYMSKGSLLDFLKGEMGKYLRLPQLVDMA AQIASGMAYVERMNYVHRDLAAANILVGENLVCKVADFGL ARLPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRV PYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRK DPEERPTFEYLQAFLEDYFTSTEPQYQPGENL B:  GHMQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWN GTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYA VVSEEPIYIVTEYMSKGSLLDFLKGEMGKYLRLPQLVDMA AQIASGMAYVERMNYVHRDLAAANILVGENLVCKVADFGL ARLIPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGR VPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWR KDPEERPTFEYLQAFLEDYFTSTEPQYQPGENL Description Functional site 1) chain A residue 273 type sequence L description BINDING SITE FOR RESIDUE PP2 A 1 source : AC1 2) chain A residue 281 type sequence V description BINDING SITE FOR RESIDUE PP2 A 1 source : AC1 3) chain A residue 293 type sequence A description BINDING SITE FOR RESIDUE PP2 A 1 source : AC1 4) chain A residue 295 type sequence K description BINDING SITE FOR RESIDUE PP2 A 1 source : AC1 5) chain A residue 314 type sequence M description BINDING SITE FOR RESIDUE PP2 A 1 source : AC1 6) chain A residue 338 type sequence T description BINDING SITE FOR RESIDUE PP2 A 1 source : AC1 7) chain A residue 339 type sequence E description BINDING SITE FOR RESIDUE PP2 A 1 source : AC1 8) chain A residue 341 type sequence M description BINDING SITE FOR RESIDUE PP2 A 1 source : AC1 9) chain A residue 345 type sequence S description BINDING SITE FOR RESIDUE PP2 A 1 source : AC1 10) chain A residue 393 type sequence L description BINDING SITE FOR RESIDUE PP2 A 1 source : AC1 11) chain B residue 273 type sequence L description BINDING SITE FOR RESIDUE PP2 B 2 source : AC2 12) chain B residue 281 type sequence V description BINDING SITE FOR RESIDUE PP2 B 2 source : AC2 13) chain B residue 293 type sequence A description BINDING SITE FOR RESIDUE PP2 B 2 source : AC2 14) chain B residue 295 type sequence K description BINDING SITE FOR RESIDUE PP2 B 2 source : AC2 15) chain B residue 314 type sequence M description BINDING SITE FOR RESIDUE PP2 B 2 source : AC2 16) chain B residue 338 type sequence T description BINDING SITE FOR RESIDUE PP2 B 2 source : AC2 17) chain B residue 339 type sequence E description BINDING SITE FOR RESIDUE PP2 B 2 source : AC2 18) chain B residue 341 type sequence M description BINDING SITE FOR RESIDUE PP2 B 2 source : AC2 19) chain B residue 345 type sequence S description BINDING SITE FOR RESIDUE PP2 B 2 source : AC2 20) chain B residue 393 type sequence L description BINDING SITE FOR RESIDUE PP2 B 2 source : AC2 21) chain A residue 527 type MOD_RES sequence Y description Phosphotyrosine; by CSK => ECO:0000269|PubMed:2420005 source Swiss-Prot : SWS_FT_FI7 22) chain B residue 527 type MOD_RES sequence Y description Phosphotyrosine; by CSK => ECO:0000269|PubMed:2420005 source Swiss-Prot : SWS_FT_FI7 23) chain A residue 386 type ACT_SITE sequence D description Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10028 source Swiss-Prot : SWS_FT_FI1 24) chain B residue 386 type ACT_SITE sequence D description Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10028 source Swiss-Prot : SWS_FT_FI1 25) chain A residue 273 type BINDING sequence L description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2 26) chain B residue 273 type BINDING sequence L description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2 27) chain A residue 273-295 type prosite sequence LGQGCFGEVWMGTWNGTTRVAIK description PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGQGCFGEVWmGtwngttr...........VAIK source prosite : PS00107 28) chain A residue 382-394 type prosite sequence YVHRDLAAANILV description PROTEIN_KINASE_TYR Tyrosine protein kinases specific active-site signature. YVHrDLAAANILV source prosite : PS00109 29) chain A residue 436 type MOD_RES sequence Y description Phosphotyrosine; by autocatalysis => ECO:0000269|PubMed:8856081 source Swiss-Prot : SWS_FT_FI5 30) chain B residue 436 type MOD_RES sequence Y description Phosphotyrosine; by autocatalysis => ECO:0000269|PubMed:8856081 source Swiss-Prot : SWS_FT_FI5 31) chain A residue 498 type MOD_RES sequence C description S-nitrosocysteine => ECO:0000269|PubMed:19948721 source Swiss-Prot : SWS_FT_FI6 32) chain B residue 498 type MOD_RES sequence C description S-nitrosocysteine => ECO:0000269|PubMed:19948721 source Swiss-Prot : SWS_FT_FI6 33) chain A residue 295 type BINDING sequence K description source Swiss-Prot : SWS_FT_FI3 34) chain B residue 295 type BINDING sequence K description source Swiss-Prot : SWS_FT_FI3

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