eF-site ID 3gdf-C PDB Code 3gdf Chain C click to enlarge Title Crystal structure of the NADP-dependent mannitol dehydrogenase from Cladosporium herbarum. Classification OXIDOREDUCTASE Compound Probable NADP-dependent mannitol dehydrogenase Source Davidiella tassiana (Mycosphaerella tassiana) (Cladosporium herbarum) (MTDH_CLAHE) Sequence C:  MPGQQATKHESLLDQLSLKGKVVVVTGASGPKGMGIEAAR GCAEMGAAVAITYASRAQGAEENVKELEKTYGIKAKAYKC QVDSYESCEKLVKDVVADFGQIDAFIANAGATADSGILDG SVEAWNHVVQVDLNGTFHCAKAVGHHFKERGTGSLVITAS MSGHIANFPQEQTSYNVAKAGCIHMARSLANEWRDFARVN SISPGYIDTGLSDFVPKETQQLWHSMIPMGRDGLAKELKG AYVYFASDASTYTTGADLLIDGGYTTR Description Functional site 1) chain C residue 267 type sequence R description BINDING SITE FOR RESIDUE ZN B 1001 source : AC3 2) chain C residue 86 type sequence E description BINDING SITE FOR RESIDUE ZN B 1002 source : AC4 3) chain C residue 89 type sequence E description BINDING SITE FOR RESIDUE ZN B 1002 source : AC4 4) chain C residue 160 type ACT_SITE sequence S description Proton donor => ECO:0000305|PubMed:20420880 source Swiss-Prot : SWS_FT_FI1 5) chain C residue 175 type ACT_SITE sequence Y description Proton donor => ECO:0000305|PubMed:20420880 source Swiss-Prot : SWS_FT_FI1 6) chain C residue 179 type ACT_SITE sequence K description Lowers pKa of active site Tyr => ECO:0000305|PubMed:20420880 source Swiss-Prot : SWS_FT_FI2 7) chain C residue 175 type BINDING sequence Y description BINDING => ECO:0000250|UniProtKB:O93868 source Swiss-Prot : SWS_FT_FI3 8) chain C residue 179 type BINDING sequence K description BINDING => ECO:0000250|UniProtKB:O93868 source Swiss-Prot : SWS_FT_FI3 9) chain C residue 207 type BINDING sequence I description BINDING => ECO:0000250|UniProtKB:O93868 source Swiss-Prot : SWS_FT_FI3 10) chain C residue 108 type BINDING sequence N description BINDING => ECO:0000250|UniProtKB:O93868 source Swiss-Prot : SWS_FT_FI3 11) chain C residue 141 type BINDING sequence K description BINDING => ECO:0000250|UniProtKB:L0E2Z4 source Swiss-Prot : SWS_FT_FI4 12) chain C residue 209 type BINDING sequence T description BINDING => ECO:0000250|UniProtKB:L0E2Z4 source Swiss-Prot : SWS_FT_FI4

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