eF-site ID 3g61-B PDB Code 3g61 Chain B click to enlarge Title Structure of P-glycoprotein Reveals a Molecular Basis for Poly-Specific Drug Binding Classification MEMBRANE PROTEIN Compound Multidrug resistance protein 1a Source (Q5I1Y5_MOUSE) Sequence B:  VSVLTMFRYAGWLDRLYMLVGTLAAIIHGVALPLMMLIFG DMTDSFASVGNVSKNSTNMSEADKRAMFAKLEEEMTTYAY YYTGIGAGVLIVAYIQVSFWCLAAGRQIHKIRQKFFHAIM NQEIGWFDVHDVGELNTRLTDDVSKINEGIGDKIGMFFQA MATFFGGFIIGFTRGWKLTLVILAISPVLGLSAGIWAKIL SSFTDKELHAYAKAGAVAEEVLAAIRTVIAFGGQKKELER YNNNLEEAKRLGIKKAITANISMGAAFLLIYASYALAFWY GTSLVISKEYSIGQVLTVFFSVLIGAFSVGQASPNIEAFA NARGAAYEVFKIIDNKPSIDSFSKSGHKPDNIQGNLEFKN IHFSYPSRKEVQILKGLNLKVKSGQTVALVGNSGCGKSTT VQLMQRLYDPLDGMVSIDGQDIRTINVRYLREIIGVVSQE PVLFATTIAENIRYGREDVTMDEIEKAVKEANAYDFIMKL PHQFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDE ATSALDTESEAVVQAALDKAREGRTTIVIAHRLSTVRNAD VIAGFDGGVIVEQGNHDELMREKGIYFKLVMTQTLDEDVP PASFWRILKLNSTEWPYFVVGIFCAIINGGLQPAFSVIFS KVVGVFTNGGPPETQRQNSNLFSLLFLILGIISFITFFLQ GFTFGKAGEILTKRLRYMVFKSMLRQDVSWFDDPKNTTGA LTTRLANDAAQVKGATGSRLAVIFQNIANLGTGIIISLIY GWQLTLLLLAIVPIIAIAGVVEMKMLSGQALKDKKELEGS GKIATEAIENFRTVVSLTREQKFETMYAQSLQIPYRNAMK KAHVFGITFSFTQAMMYFSYAACFRFGAYLVTQQLMTFEN VLLVFSAIVFGAMAVGQVSSFAPDYAKATVSASHIIRIIE KTPEIDSYSTQGLKPNMLEGNVQFSGVVFNYPTRPSIPVL QGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPMAGS VFLDGKEIKQLNVQWLRAQLGIVSQEPILFDCSIAENIAY GDNSRVVSYEEIVRAAKEANIHQFIDSLPDKYNTRVGDKG TQLSGGQKQRIAIARALVRQPHILLLDEATSALDTESEKV VQEALDKAREGRTCIVIAHRLSTIQNADLIVVIQNGKVKE HGTHQQLLAQKGIYFSMVSVQA Description Functional site 1) chain B residue 303 type sequence Y description BINDING SITE FOR RESIDUE 2J8 B 6003 source : AC3 2) chain B residue 339 type sequence F description BINDING SITE FOR RESIDUE 2J8 B 6003 source : AC3 3) chain B residue 721 type sequence Q description BINDING SITE FOR RESIDUE 2J8 B 6003 source : AC3 4) chain B residue 724 type sequence F description BINDING SITE FOR RESIDUE 2J8 B 6003 source : AC3 5) chain B residue 978 type sequence V description BINDING SITE FOR RESIDUE 2J8 B 6003 source : AC3 6) chain B residue 982 type sequence M description BINDING SITE FOR RESIDUE 2J8 B 6003 source : AC3 7) chain B residue 985 type sequence G description BINDING SITE FOR RESIDUE 2J8 B 6003 source : AC3 8) chain B residue 986 type sequence Q description BINDING SITE FOR RESIDUE 2J8 B 6003 source : AC3 9) chain B residue 989 type sequence S description BINDING SITE FOR RESIDUE 2J8 B 6003 source : AC3 10) chain B residue 332 type sequence F description BINDING SITE FOR RESIDUE 2J8 B 6004 source : AC4 11) chain B residue 336 type sequence I description BINDING SITE FOR RESIDUE 2J8 B 6004 source : AC4 12) chain B residue 949 type sequence Y description BINDING SITE FOR RESIDUE 2J8 B 6004 source : AC4 13) chain B residue 974 type sequence F description BINDING SITE FOR RESIDUE 2J8 B 6004 source : AC4 14) chain B residue 978 type sequence V description BINDING SITE FOR RESIDUE 2J8 B 6004 source : AC4 15) chain B residue 44-66 type TRANSMEM sequence WLDRLYMLVGTLAAIIHGVALPL description Helical source Swiss-Prot : SWS_FT_FI2 16) chain B residue 113-133 type TRANSMEM sequence YYTGIGAGVLIVAYIQVSFWC description Helical source Swiss-Prot : SWS_FT_FI2 17) chain B residue 183-204 type TRANSMEM sequence GDKIGMFFQAMATFFGGFIIGF description Helical source Swiss-Prot : SWS_FT_FI2 18) chain B residue 212-232 type TRANSMEM sequence LVILAISPVLGLSAGIWAKIL description Helical source Swiss-Prot : SWS_FT_FI2 19) chain B residue 291-312 type TRANSMEM sequence ANISMGAAFLLIYASYALAFWY description Helical source Swiss-Prot : SWS_FT_FI2 20) chain B residue 327-348 type TRANSMEM sequence VLTVFFSVLIGAFSVGQASPNI description Helical source Swiss-Prot : SWS_FT_FI2 21) chain B residue 708-728 type TRANSMEM sequence VVGIFCAIINGGLQPAFSVIF description Helical source Swiss-Prot : SWS_FT_FI2 22) chain B residue 753-773 type TRANSMEM sequence LLFLILGIISFITFFLQGFTF description Helical source Swiss-Prot : SWS_FT_FI2 23) chain B residue 829-849 type TRANSMEM sequence LAVIFQNIANLGTGIIISLIY description Helical source Swiss-Prot : SWS_FT_FI2 24) chain B residue 851-870 type TRANSMEM sequence WQLTLLLLAIVPIIAIAGVV description Helical source Swiss-Prot : SWS_FT_FI2 25) chain B residue 931-953 type TRANSMEM sequence AHVFGITFSFTQAMMYFSYAACF description Helical source Swiss-Prot : SWS_FT_FI2 26) chain B residue 970-991 type TRANSMEM sequence VLLVFSAIVFGAMAVGQVSSFA description Helical source Swiss-Prot : SWS_FT_FI2 27) chain B residue 233-290 type TOPO_DOM sequence SSFTDKELHAYAKAGAVAEEVLAAIRTVIAFGGQKKELER YNNNLEEAKRLGIKKAIT description Cytoplasmic => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 28) chain B residue 349-707 type TOPO_DOM sequence EAFANARGAAYEVFKIIDNKPSIDSFSKSGHKPDNIQGNL EFKNIHFSYPSRKEVQILKGLNLKVKSGQTVALVGNSGCG KSTTVQLMQRLYDPLDGMVSIDGQDIRTINVRYLREIIGV VSQEPVLFATTIAENIRYGREDVTMDEIEKAVKEANAYDF IMKLPHQFDTLVGERGAQLSGGQKQRIAIARALVRNPKIL LLDEATSALDTESEAVVQAALDKAREGRTTIVIAHRLSTV RNADVIAGFDGGVIVEQGNHDELMREKGIYFKLVMTQTLD EDVPPASFWRILKLNSTEWPYF description Cytoplasmic => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 29) chain B residue 774-828 type TOPO_DOM sequence GKAGEILTKRLRYMVFKSMLRQDVSWFDDPKNTTGALTTR LANDAAQVKGATGSR description Cytoplasmic => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 30) chain B residue 871-930 type TOPO_DOM sequence EMKMLSGQALKDKKELEGSGKIATEAIENFRTVVSLTREQ KFETMYAQSLQIPYRNAMKK description Cytoplasmic => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 31) chain B residue 134-182 type TOPO_DOM sequence LAAGRQIHKIRQKFFHAIMNQEIGWFDVHDVGELNTRLTD DVSKINEGI description Cytoplasmic => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 32) chain B residue 729-752 type TOPO_DOM sequence SKVVGVFTNGGPPETQRQNSNLFS description Extracellular => ECO:0000250 source Swiss-Prot : SWS_FT_FI3 33) chain B residue 850 type TOPO_DOM sequence G description Extracellular => ECO:0000250 source Swiss-Prot : SWS_FT_FI3 34) chain B residue 954-969 type TOPO_DOM sequence RFGAYLVTQQLMTFEN description Extracellular => ECO:0000250 source Swiss-Prot : SWS_FT_FI3 35) chain B residue 67-112 type TOPO_DOM sequence MMLIFGDMTDSFASVGNVSKNSTNMSEADKRAMFAKLEEE MTTYAY description Extracellular => ECO:0000250 source Swiss-Prot : SWS_FT_FI3 36) chain B residue 205-211 type TOPO_DOM sequence TRGWKLT description Extracellular => ECO:0000250 source Swiss-Prot : SWS_FT_FI3 37) chain B residue 313-326 type TOPO_DOM sequence GTSLVISKEYSIGQ description Extracellular => ECO:0000250 source Swiss-Prot : SWS_FT_FI3 38) chain B residue 423 type BINDING sequence G description BINDING => ECO:0000255|PROSITE-ProRule:PRU00434 source Swiss-Prot : SWS_FT_FI4 39) chain B residue 1066 type BINDING sequence G description BINDING => ECO:0000255|PROSITE-ProRule:PRU00434 source Swiss-Prot : SWS_FT_FI4 40) chain B residue 83 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000255 source Swiss-Prot : SWS_FT_FI6 41) chain B residue 87 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000255 source Swiss-Prot : SWS_FT_FI6 42) chain B residue 90 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000255 source Swiss-Prot : SWS_FT_FI6

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