eF-site ID 3g61-A PDB Code 3g61 Chain A click to enlarge Title Structure of P-glycoprotein Reveals a Molecular Basis for Poly-Specific Drug Binding Classification MEMBRANE PROTEIN Compound Multidrug resistance protein 1a Source (Q5I1Y5_MOUSE) Sequence A:  VSVLTMFRYAGWLDRLYMLVGTLAAIIHGVALPLMMLIFG DMTDSFASVGNVSKNSTNMSEADKRAMFAKLEEEMTTYAY YYTGIGAGVLIVAYIQVSFWCLAAGRQIHKIRQKFFHAIM NQEIGWFDVHDVGELNTRLTDDVSKINEGIGDKIGMFFQA MATFFGGFIIGFTRGWKLTLVILAISPVLGLSAGIWAKIL SSFTDKELHAYAKAGAVAEEVLAAIRTVIAFGGQKKELER YNNNLEEAKRLGIKKAITANISMGAAFLLIYASYALAFWY GTSLVISKEYSIGQVLTVFFSVLIGAFSVGQASPNIEAFA NARGAAYEVFKIIDNKPSIDSFSKSGHKPDNIQGNLEFKN IHFSYPSRKEVQILKGLNLKVKSGQTVALVGNSGCGKSTT VQLMQRLYDPLDGMVSIDGQDIRTINVRYLREIIGVVSQE PVLFATTIAENIRYGREDVTMDEIEKAVKEANAYDFIMKL PHQFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDE ATSALDTESEAVVQAALDKAREGRTTIVIAHRLSTVRNAD VIAGFDGGVIVEQGNHDELMREKGIYFKLVMTQTLDEDVP PASFWRILKLNSTEWPYFVVGIFCAIINGGLQPAFSVIFS KVVGVFTNGGPPETQRQNSNLFSLLFLILGIISFITFFLQ GFTFGKAGEILTKRLRYMVFKSMLRQDVSWFDDPKNTTGA LTTRLANDAAQVKGATGSRLAVIFQNIANLGTGIIISLIY GWQLTLLLLAIVPIIAIAGVVEMKMLSGQALKDKKELEGS GKIATEAIENFRTVVSLTREQKFETMYAQSLQIPYRNAMK KAHVFGITFSFTQAMMYFSYAACFRFGAYLVTQQLMTFEN VLLVFSAIVFGAMAVGQVSSFAPDYAKATVSASHIIRIIE KTPEIDSYSTQGLKPNMLEGNVQFSGVVFNYPTRPSIPVL QGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPMAGS VFLDGKEIKQLNVQWLRAQLGIVSQEPILFDCSIAENIAY GDNSRVVSYEEIVRAAKEANIHQFIDSLPDKYNTRVGDKG TQLSGGQKQRIAIARALVRQPHILLLDEATSALDTESEKV VQEALDKAREGRTCIVIAHRLSTIQNADLIVVIQNGKVKE HGTHQQLLAQKGIYFSMVSVQA Description Functional site 1) chain A residue 300 type sequence L description BINDING SITE FOR RESIDUE 2J8 A 6001 source : AC1 2) chain A residue 303 type sequence Y description BINDING SITE FOR RESIDUE 2J8 A 6001 source : AC1 3) chain A residue 339 type sequence F description BINDING SITE FOR RESIDUE 2J8 A 6001 source : AC1 4) chain A residue 978 type sequence V description BINDING SITE FOR RESIDUE 2J8 A 6001 source : AC1 5) chain A residue 985 type sequence G description BINDING SITE FOR RESIDUE 2J8 A 6001 source : AC1 6) chain A residue 332 type sequence F description BINDING SITE FOR RESIDUE 2J8 A 6002 source : AC2 7) chain A residue 728 type sequence F description BINDING SITE FOR RESIDUE 2J8 A 6002 source : AC2 8) chain A residue 949 type sequence Y description BINDING SITE FOR RESIDUE 2J8 A 6002 source : AC2 9) chain A residue 971 type sequence L description BINDING SITE FOR RESIDUE 2J8 A 6002 source : AC2 10) chain A residue 974 type sequence F description BINDING SITE FOR RESIDUE 2J8 A 6002 source : AC2 11) chain A residue 977 type sequence I description BINDING SITE FOR RESIDUE 2J8 A 6002 source : AC2 12) chain A residue 978 type sequence V description BINDING SITE FOR RESIDUE 2J8 A 6002 source : AC2 13) chain A residue 134-182 type TOPO_DOM sequence LAAGRQIHKIRQKFFHAIMNQEIGWFDVHDVGELNTRLTD DVSKINEGI description Cytoplasmic => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 14) chain A residue 233-290 type TOPO_DOM sequence SSFTDKELHAYAKAGAVAEEVLAAIRTVIAFGGQKKELER YNNNLEEAKRLGIKKAIT description Cytoplasmic => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 15) chain A residue 349-707 type TOPO_DOM sequence EAFANARGAAYEVFKIIDNKPSIDSFSKSGHKPDNIQGNL EFKNIHFSYPSRKEVQILKGLNLKVKSGQTVALVGNSGCG KSTTVQLMQRLYDPLDGMVSIDGQDIRTINVRYLREIIGV VSQEPVLFATTIAENIRYGREDVTMDEIEKAVKEANAYDF IMKLPHQFDTLVGERGAQLSGGQKQRIAIARALVRNPKIL LLDEATSALDTESEAVVQAALDKAREGRTTIVIAHRLSTV RNADVIAGFDGGVIVEQGNHDELMREKGIYFKLVMTQTLD EDVPPASFWRILKLNSTEWPYF description Cytoplasmic => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 16) chain A residue 774-828 type TOPO_DOM sequence GKAGEILTKRLRYMVFKSMLRQDVSWFDDPKNTTGALTTR LANDAAQVKGATGSR description Cytoplasmic => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 17) chain A residue 871-930 type TOPO_DOM sequence EMKMLSGQALKDKKELEGSGKIATEAIENFRTVVSLTREQ KFETMYAQSLQIPYRNAMKK description Cytoplasmic => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 18) chain A residue 67-112 type TOPO_DOM sequence MMLIFGDMTDSFASVGNVSKNSTNMSEADKRAMFAKLEEE MTTYAY description Extracellular => ECO:0000250 source Swiss-Prot : SWS_FT_FI3 19) chain A residue 205-211 type TOPO_DOM sequence TRGWKLT description Extracellular => ECO:0000250 source Swiss-Prot : SWS_FT_FI3 20) chain A residue 313-326 type TOPO_DOM sequence GTSLVISKEYSIGQ description Extracellular => ECO:0000250 source Swiss-Prot : SWS_FT_FI3 21) chain A residue 729-752 type TOPO_DOM sequence SKVVGVFTNGGPPETQRQNSNLFS description Extracellular => ECO:0000250 source Swiss-Prot : SWS_FT_FI3 22) chain A residue 954-969 type TOPO_DOM sequence RFGAYLVTQQLMTFEN description Extracellular => ECO:0000250 source Swiss-Prot : SWS_FT_FI3 23) chain A residue 850 type TOPO_DOM sequence G description Extracellular => ECO:0000250 source Swiss-Prot : SWS_FT_FI3 24) chain A residue 423 type BINDING sequence G description BINDING => ECO:0000255|PROSITE-ProRule:PRU00434 source Swiss-Prot : SWS_FT_FI4 25) chain A residue 1066 type BINDING sequence G description BINDING => ECO:0000255|PROSITE-ProRule:PRU00434 source Swiss-Prot : SWS_FT_FI4 26) chain A residue 90 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000255 source Swiss-Prot : SWS_FT_FI6 27) chain A residue 83 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000255 source Swiss-Prot : SWS_FT_FI6 28) chain A residue 87 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000255 source Swiss-Prot : SWS_FT_FI6 29) chain A residue 527-541 type prosite sequence LSGGQKQRIAIARAL description ABC_TRANSPORTER_1 ABC transporters family signature. LSGGQKQRIAIARAL source prosite : PS00211 30) chain A residue 1172-1186 type prosite sequence LSGGQKQRIAIARAL description ABC_TRANSPORTER_1 ABC transporters family signature. LSGGQKQRIAIARAL source prosite : PS00211 31) chain A residue 44-66 type TRANSMEM sequence WLDRLYMLVGTLAAIIHGVALPL description Helical source Swiss-Prot : SWS_FT_FI2 32) chain A residue 113-133 type TRANSMEM sequence YYTGIGAGVLIVAYIQVSFWC description Helical source Swiss-Prot : SWS_FT_FI2 33) chain A residue 183-204 type TRANSMEM sequence GDKIGMFFQAMATFFGGFIIGF description Helical source Swiss-Prot : SWS_FT_FI2 34) chain A residue 212-232 type TRANSMEM sequence LVILAISPVLGLSAGIWAKIL description Helical source Swiss-Prot : SWS_FT_FI2 35) chain A residue 291-312 type TRANSMEM sequence ANISMGAAFLLIYASYALAFWY description Helical source Swiss-Prot : SWS_FT_FI2 36) chain A residue 327-348 type TRANSMEM sequence VLTVFFSVLIGAFSVGQASPNI description Helical source Swiss-Prot : SWS_FT_FI2 37) chain A residue 708-728 type TRANSMEM sequence VVGIFCAIINGGLQPAFSVIF description Helical source Swiss-Prot : SWS_FT_FI2 38) chain A residue 753-773 type TRANSMEM sequence LLFLILGIISFITFFLQGFTF description Helical source Swiss-Prot : SWS_FT_FI2 39) chain A residue 829-849 type TRANSMEM sequence LAVIFQNIANLGTGIIISLIY description Helical source Swiss-Prot : SWS_FT_FI2 40) chain A residue 851-870 type TRANSMEM sequence WQLTLLLLAIVPIIAIAGVV description Helical source Swiss-Prot : SWS_FT_FI2 41) chain A residue 931-953 type TRANSMEM sequence AHVFGITFSFTQAMMYFSYAACF description Helical source Swiss-Prot : SWS_FT_FI2 42) chain A residue 970-991 type TRANSMEM sequence VLLVFSAIVFGAMAVGQVSSFA description Helical source Swiss-Prot : SWS_FT_FI2

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